Measuring Serum Thyroglobulin in Patients with Follicular Thyroid Nodule: Its Diagnostic Implications.

Abstract

Abstract.To The diagnostic value of serum Tg was examined by means of receiver operating characteristic (ROC) curves. There were significant correlations between the serum Tg level and the maximum diameter of the nodule, the macroscopic characteristics, and the smoking habit. The sensitivity and specificity of the serum Tg level with a cut-off value of 1,000 µg/1 were 57% and 86%, respectively.The likelihood ratio favouring follicular carcinoma associated with the serum Tg > 1,000 µg/l was 4.41. Measuring the level of serum Tg may be useful in discriminating follicular carcinoma from follicular adenoma, but since there may be some biases in this retrospective study, the results are less definitive. Further research activities are mandatory to obtain valid evidence.

Carcinoma folicular de tireóide: estudo retrospectivo

“…Apenas um dos nossos doentes apresentava TSH suprimido e sinais e sintomas de hipertireoidismo quando do diagnóstico. Os níveis de TG sérica também não são específicos para diagnóstico pré-operató-rio 8 , embora sejam marcadores bastante sensíveis de recidiva tumoral após tireoidectomia total -100% dos pacientes recidivados apresentavam TG sérica elevada.…”

“…Técnicas têm sido descritas, porém sem sucesso até o momento [8][9][10][11] . A PAAF tornou-se o melhor método em termos de custo e acurácia para diagnóstico pré-operatório de neoplasia papilífera, medular e anaplásica de tireóide, porém ainda é de pouca ajuda quando se trata de diferenciar lesões foliculares (hiperplasias, adenomas e carcinomas).…”

Der Schilddrüsenknoten und der Stellenwert der Tumormarkerbestimmung

“…73 % (NPV) kamen bei einer Sensitivität von 20 % und Spezifität von 96 % (in einer ROC-Analyse zeigte die 201 Tl-Szintigrafie vergleichsweise bessere Ergebnisse). In einer weiteren japanischen Studie [28] wurde bei einem identischen Cutoff-Wert von 1000 ng / ml für die Dignitätsabklärung von Solitärknoten eine Sensitivität von 57 % und Spezifität von 86 % ermittelt. Allerdings lassen sich diese japanischen Daten wegen der Unterschiede hinsichtlich Epidemiologie und Iodversorgung nicht ohne weiteres auf deutsche Verhältnisse übertragen.…”

Effect of single‐nucleotide polymorphism in TERT promoter on follicular thyroid tumor development

“…Molecular testing of these tumors has recently been performed . Clinical findings indicating FTC include high serum thyroglobulin (Tg) >1000 ng/mL, size >4.0 cm, presence of metastasis, and ultrasound features suggesting capsular invasion . Follicular thyroid tumors without clinical findings indicating FTC are also treated by surgical excision when their growth rates are high.…”