Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia

Soluble Growth Stimulation Gene-2 Level on Severe Preeclampsia Patients without and with Complications

“…The AUC of sST2 was 96.1% (p < 0.001, 95% CI 91.8-100%). This value was better than that of Southcombe et al 14 who got AUC of 97% placental growth factor and 89.1% sST2 level (p < 0.05). Although we obtained a better result of sST2 level, this value could not be considered as preeclampsia predictor due to the study design and hence, we recommend conducting further longitudinal studies to determine the value of sST2.…”

Maternal plasma-soluble ST2 concentrations are elevated prior to the development of early and late onset preeclampsia – a longitudinal study

“…Our group and other investigators reported an increase of circulating sST2 in the maternal plasma of patients with preeclampsia in comparison to those with normal pregnancies (84,85,169). In addition, women with early-onset preeclampsia had higher sST2 concentrations than those with late onset of this syndrome.…”