Increased serum levels of sFlt-1/PlGF ratio in preeclamptic women with onset at <32 weeks compared with ≥32 weeks

Markedly higher sFlt‐1/PlGF ratio in a woman with acute fatty liver of pregnancy compared with HELLP syndrome

“…The level of sFlt‐1 and sFlt‐1/PlGF ratio in the woman with AFLP was 18 (=275 423 ÷ 15 488) and 18 (=4266 ÷ 234) times higher than the mean level of sFlt‐1 and sFlt‐1/PlGF ratio in women with HELLP syndrome, respectively. We did not encounter pregnant women with a serum level of sFlt‐1 greater than 100 000 pg/mL using the ECLIA method, including normal and pre‐eclamptic women . In women with HELLP syndrome, the levels of sFlt‐1 were all less than 100 000 pg/mL.…”

“…In 2004–2008 (Rin‐03‐01) and 2012–2016 (I‐12‐78), two different prospective cohort studies were planned to evaluate the circulating levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio in women with gestational hypertension, gestational proteinuria and pre‐eclampsia. In 2009, we also constructed the reference ranges of serum levels of the sFlt‐1/PlGF ratio, using the data collected in the Rin‐03‐01 study, with a fund for contract research from Roche Diagnostics K. K. (Rin‐09‐02) . All three studies were approved by the Ethics Committee of Jichi Medical University.…”

“…We recently established normal reference ranges of serum levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio in pregnant women at 19–38 weeks of gestation . A high sFlt‐1 was defined as a level of sFlt‐1 equal to or higher than the 95th percentile curve of gestational‐age‐specific normal reference ranges of serum sFlt‐1 levels; a low PlGF was defined as a level of PlGF lower than the 5th percentile curve of gestational‐age‐specific normal reference ranges of serum PlGF levels; and a high sFlt‐1/PlGF ratio was defined as a ratio equal to or higher than the 95th percentile curve of gestational‐age‐specific normal reference ranges of the serum sFlt‐1/PlGF ratio …”

“…Continuous data are presented as the mean ±standard deviation (SD) or standard error, or median with interquartile range and categorical data are presented as frequency counts (%). For serum levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio, statistical testing was conducted after logarithmic transformation, because in our previous studies using serum levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio, the data showed almost normal distributions after logarithmic transformation . However, the data of serum levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio were presented using the absolute values instead of logarithmic values.…”

Effect of magnesium sulfate combined with labetalol on serum sFlt‑1/PlGF ratio in patients with early‑onset severe pre‑eclampsia

“…Soluble Fms-like tyrosine kinase-1 (sFlT-1) and placental growth factor (PlGF) are major anti-angiogenic factors (8). Previous studies have shown that increase of sFlT-1 levels and decrease of PlGF levels can break the balance of placental angiogenesis, resulting in insufficient invasion of trophoblast cells to the endometrium, ischemia and hypoxia in the placenta, eventually leading to PE (9,10). Thus, sFlT-1 and PlGF may play important roles in the pathogenesis of ES-PE (11).…”