Soluble Growth Stimulation Gene-2 Level on Severe Preeclampsia Patients without and with Complications

Maharani, Laksmi; Wibowo, Noroyono

doi:10.5005/jp-journals-10006-1573

Cited by 6 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 Maharani et al also found that sST2 is signi cantly elevated in preeclampsia population and tend to increase in preeclampsia with complication. 20 Mean value of sST2 in this study is 145.75 ng/ml, which is higher than other similar studies. This wide difference of median sST2 may have been caused by a disproportionate occurrence of early-and lateonset preeclampsia as most of previous studies do not differentiate the population based on onset of preeclampsia.…”

Section: Discussioncontrasting

confidence: 70%

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Prameswari,

Effendi,

Khalid

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Early onset preeclampsia, defined as preeclampsia that occurs before 34th weeks, has a higher cardiovascular events due to higher cytokine concentrations. Hemodynamic changes in preeclampsia can trigger cardiac remodeling as indicated by increase of soluble-ST2 (sST2). Global longitudinal strain were able to detect systolic dysfunction better than the ejection fraction. This study aims to evaluate the correlation between serum levels of sST2 towards GLS in patients with early-onset preeclampsia. Methods: This is a cross-sectional observational study with correlation analysis. Subjects were patients with severe preeclampsia with gestational age before 34 weeks at Dr. Hasan Sadikin Bandung and Bandung Kiwari Regional General Hospital from June to August 2022. Examination of sST2 was carried out through blood samples using the ELISA method. sST2 was measured using Presage ST2 Assay reagent. GLS examination was carried out using speckle tracking technique with EchoPAC. Correlation analysis was conducted using the Pearson test if normally distributed, otherwise Spearman's correlation was conducted. Correlation analysis was followed by linear regression. Results: A total of 30 patients met the inclusion criteria. The mean age was 30.83 ± 7.09, with 17 (56.7%) multiparous patients. The median sST2 was 145.75 ng/mL, and the median GLS was -17.4%. Spearman correlation analysis showed that there was a significant negative correlation with moderate strength between sST2 and GLS (r=0.583; p<0.002). Linear regression showed that every 1 ng/ml increase in sST2 would give a decrease in GLS of 0.014%. Conclusion: There is a significant correlation between sST2 and GLS in patients with early onset severe preeclampsia.

show abstract

Section: Discussioncontrasting

confidence: 70%

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Prameswari,

Effendi,

Khalid

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Multivariate analysis also found normal pregnancy and preeclampsia to be the best explanatory variable for sST2 levels. Previous studies have demonstrated a pathological increase of sST2 levels in patients with preeclampsia [10] , [13] , [14] . Our results, which were obtained primarily from patients of Malay ethnicity, exhibited similar sST2 characteristics in normal pregnancy and preeclampsia to those of Western populations, which are composed of different ethnic groups than those considered in the current study.…”

Section: Discussionmentioning

confidence: 90%

Differences in maternal soluble ST2 levels in the third trimester of normal pregnancy versus preeclampsia

Prameswari

Khalid

Anggraeni

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Background Preeclampsia is associated with intense inflammatory response in pregnancy, and soluble ST2 (sST2) is pathologically increased in this condition. No data exist regarding maternal sST2 levels in normal pregnancy versus preeclampsia in areas of southeast Asia with an ethnic Malay predominance. Materials and Methods Patients were sorted into normal pregnancy or preeclampsia. Patients with a history of allergic, inflammatory, or malignant disease were excluded. One sample was taken per patient; all samples were taken during the third trimester of pregnancy. Thirty samples from each group were enrolled in the study, totaling 60 samples. Soluble ST2 levels in maternal plasma were measured using the Presage® ST2 Assay according to manufacturer instructions, and data was analyzed using SPSS 23. Results Patients in the preeclampsia group were significantly older than those in the normal pregnancy group (p = 0.01). Most patients with preeclampsia presented as early-onset (n = 23). Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher (p < 0.001) in the preeclampsia group. Mean sST2 level in the preeclampsia group (85.89 ng/ml) was significantly higher than the normal pregnancy group mean (38.3 ng/ml) during the third trimester (p < 0.001). This study also found a correlation between sST2 and preeclampsia (p < 0.001, r = 0.480), SBP (p < 0.001, r = 0.407), and DBP (p = 0.007, r = 0.342), while preeclampsia was found to be the best explanatory variable of sST2 levels (r = 0.468, p < 0.001). sST2 level> 63.66 ng/ml has sensitivity 50% and specificity 93.3%, with AUC of 0.78 [95% CI 0.66 – 0.90], p < 0.001. The sST2 > 63.66 ng/ml has an OR of 14.0 [95% CI 2.82 – 69.6], p < 0.001 for preeclampsia. The dose-response relationship between sST2 level and preeclampsia was linear. Conclusion Soluble ST2 levels were increased in both normal pregnancy and preeclampsia but were significantly higher in patients with preeclampsia. Preeclampsia was also found to be the best explanatory variable for the increase of sST2 levels in ethnic Malay predominance.

show abstract

“…The degree of myocardial injury depends on the severity and onset of preeclampsia. Soluble ST2, which is a marker of fibrosis, will be elevated proportionately with severity of preeclampsia [ 19 ]. Our previous study found that median sST2 of third trimester pregnancy were 66.48 ng/ml and it was found that preeclampsia was the most contributing factor in the elevation of sST2 in pregnancy [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Stampalija et al found that median value of sST2 was 76.1 ng/ml and the value of sST2 is higher depends on the severity of preeclampsia [ 21 ]. Maharani et al also found that sST2 is significantly elevated in preeclampsia population and tend to increase in preeclampsia with complication [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Prameswari,

Effendi,

Khalid

et al. 2024

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Preeclampsia is one of the leading causes of death in childbearing women worldwide. Hemodynamic changes in preeclampsia can trigger cardiac remodeling as indicated by increase of soluble-ST2 (sST2). Global longitudinal strain were able to detect systolic dysfunction better than the ejection fraction. This study aims to evaluate the correlation between serum levels of sST2 towards GLS in patients with early-onset preeclampsia. Methods This is a cross-sectional observational study with correlation analysis. Subjects were patients with severe preeclampsia with gestational age before 34 weeks at Dr. Hasan Sadikin Central General Hospital Bandung and Bandung Kiwari Regional General Hospital from June to August 2022. Examination of sST2 was carried out through blood samples using the ELISA method. sST2 was measured using Presage ST2 Assay reagent. GLS examination was carried out using speckle tracking technique with EchoPAC. Correlation analysis was conducted using the Pearson test if normally distributed, otherwise Spearman’s correlation was conducted. Correlation analysis was followed by linear regression. Results A total of 30 patients met the inclusion criteria. The mean age was 30.83 ± 7.09, with 17 (56.7%) multiparous patients. The median sST2 was 145.75 ng/mL, and the median GLS was − 17.4%. Spearman correlation analysis showed that there was a significant positive correlation with moderate strength between sST2 and GLS (r = 0.583; p < 0.002). Linear regression showed that every 1 ng/ml increase in sST2 would give an increase in GLS of 0.014%. Conclusion There is a significant correlation between sST2 and GLS in patients with early onset severe preeclampsia.

show abstract

Soluble Growth Stimulation Gene-2 Level on Severe Preeclampsia Patients without and with Complications

Cited by 6 publications

References 12 publications

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Differences in maternal soluble ST2 levels in the third trimester of normal pregnancy versus preeclampsia

Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia

Contact Info

Product

Resources

About