Measurement of liver fat by magnetic resonance imaging: relationships with body fat distribution, insulin sensitivity and plasma lipids in healthy men

Abstract

These data suggest that MRI is as good as MRS to quantify liver fat content. Our data also suggest that liver fat content could link intraabdominal fat with insulin resistance and dyslipidaemia.

In vivo imaging of lipid storage and regression in diet-induced obesity during nutrition manipulation

“…The steep increase in HOMA was driven by plasma insulin levels rather than changes in plasma glucose (data not shown). This is consistent with clinical studies relating insulin resistance to hepatic lipid accumulation (6,28). From these experiments it is not possible to determine whether it is total BW, liver TG, or some other factor that best predicts the metabolic break point.…”

Body and liver fat content and adipokines in schizophrenia: a magnetic resonance imaging and spectroscopy study

“…The results of our study are consistent with those of previous studies and support the suggestion that a direct effect is involved in the mechanism of hypertriglyceridemia associated with antipsychotics. Chan et al (2006) reported a significant correlation between plasma triglyceride levels and liver fat content as measured by MRS. In addition, both triglycerides and adiponectin were significant predictors of visceral fat volume as measured by MRI in women (Neamat-Allah et al 2015).…”

Investigation of the Anti-Obesity Action of Licorice Flavonoid Oil in Diet-Induced Obese Rats

“…13,14) The hepatic TG content is significantly correlated with plasma TG level and fat mass in humans. 15) The hepatic TG availability is controlled by the balance between fatty acid synthesis and oxidation in the liver. 16) Hence we hypothesized that LFO suppresses fatty acid synthesis and/or promotes fatty acid oxidation in the liver, which in turn results in decreases in the concentrations of hepatic and plasma TGs and the weight of abdominal fat.…”