Investigation of the Anti-Obesity Action of Licorice Flavonoid Oil in Diet-Induced Obese Rats

Kamisoyama, Hiroshi; Honda, Kazuhisa; Tominaga, Yasunori; Yokota, Shinichi; Hasegawa, Shin

doi:10.1271/bbb.80469

Cited by 66 publications

(53 citation statements)

References 39 publications

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“…Similarly, other studies have shown a decreased expression of FASN due to different flavonoids in HFD-fed animals (63,64). In addition, several other studies also describe flavonoids that inhibit FASN activity (65)(66)(67)(68)(69)(70)(71)(72). Specifically, Kweon et al (73) also found that the activity of FASN in rat liver was lowered by half by treatment with a grape seed extract.…”

Section: Discussionmentioning

confidence: 87%

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Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease. We studied the effect of grape seed proanthocyanidin extract (GSPE) in rats fed a high fat diet (HFD). This is the first study of the effects of flavonoids on the liver proteome of rats suffering from metabolic syndrome. Three groups of rats were fed over a period of 13 weeks either a chow diet (control), an HFD, or a high fat diet supplemented for the last 10 days with GSPE (HFD ؉ GSPE). The liver proteome was fractionated, using a Triton X-114-based two-phase separation, into soluble and membrane protein fractions so that total proteome coverage was considerably improved. The data from isobaric tag for relative and absolute quantitation (

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Section: Discussionmentioning

confidence: 87%

“…This would further confirm the effect of GSPE at an upstream transcriptional regulatory level, although additional direct effects on the expression or functionality of individual proteins cannot be ruled out. Similarly, other flavonoids decrease SREBP1c, ACACA, and FASN liver expression (63,64) and activity (71) in rats fed an HFD.…”

Section: Discussionmentioning

confidence: 90%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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“…These results suggest that ingestion of LFO enhances energy consumption, especially fat oxidation. These results may be explained, at least in part, by the fact that in previous studies the administration of LFO suppressed fatty acid synthesis and activated peroxisomal beta-oxidation in the liver of mice and rats (4,14). It was postulated that the suppression of fatty acid synthesis and the enhancement of peroxisomal beta-oxidation resulted in the selective enhancement of fat oxidation.…”

Section: Discussionmentioning

confidence: 92%

Enhancement of Fat Oxidation by Licorice Flavonoid Oil in Healthy Humans during Light Exercise

Mori

Nakanishi

Shiomi

et al. 2015

J Nutr Sci Vitaminol

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Summary Licorice flavonoid oil (LFO) is a new functional food ingredient consisting of hydrophobic licorice polyphenols in medium-chain triglycerides. Recent studies reported that LFO prevented and ameliorated diet-induced obesity via the regulation of lipid metabolism-related gene expression in the livers of mice and rats, while it reduced body weight in overweight human subjects by reducing total body fat. However, the direct effects of LFO on energy metabolism have not been studied in human subjects. Therefore, we investigated the effects of ingestion of LFO on energy metabolism, including fat oxidation, by measuring body surface temperature under resting conditions and respiratory gas analysis under exercise conditions in healthy humans. We showed that ingestion of a single 600 mg dose of LFO elevated body trunk skin temperature when measured in a slightly cooled air-conditioned room, and increased oxygen consumption and decreased the respiratory exchange ratio as measured by respiratory gas analysis during 40% Vo2max exercise with a cycle ergometer. Furthermore, repeated ingestion of 300 mg of LFO for 8 d decreased respiratory exchange during the recovery period following 40 min of 30% Vo2max exercise on a treadmill. These results suggest that LFO enhances fat oxidation in humans during light exercise. Key Words licorice, flavonoid, respiratory exchange ratio, fat oxidation, humans Licorice is widely consumed as a food and natural medicine/herbal drug in both Eastern and Western countries (1). There are several species of licorice, including Glycyrrhiza uralensis Fischer, G. glabra Linne, and G. inflata Batalin, each of which contain specific flavonoids (1).Licorice flavonoid oil (LFO) is a new functional food ingredient containing hydrophobic flavonoids derived from G. glabra (2). Our previous study suggested that LFO is effective in reducing visceral fat accumulation and suppressing elevated blood glucose levels in obese diabetic KK-Ay mice (2). Subsequently, a double-blind placebo-controlled clinical trial showed that LFO was effective in suppressing body weight gain by reducing body fat mass in overweight volunteers (3). These studies indicate that LFO may help to prevent lifestylerelated diseases such as obesity associated with metabolic syndrome. The mechanism of the antiobesity effect of LFO was previously investigated in a high-fat diet-induced obese C57BL/6J mouse model and the results suggest that the effect was mediated by modification of the expression levels of lipid metabolism-related genes in the liver (4). In particular, it has been shown that LFO increases the enzymatic activity of acyl-coA dehydrogenase, the rate-limiting enzyme in the fatty acid oxidative pathway, and simultaneously decreases the enzyme activity of acetyl-coA carboxylase and fatty acid synthase, the rate-limiting enzymes in the fatty acid synthetic pathway.These studies suggest that LFO may alter energy metabolism, especially fat degradation. However, there is no information regarding the short-acting effects of LFO on en...

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“…1) There is evidence that a depletion of hepatic cholesterol pools suppresses the secretion of very low density lipoprotein (VLDL) from the liver and promotes the uptake of plasma low density lipoprotein (LDL) by the liver. [2][3][4] Numerous studies suggest that lowering plasma VLDL and LDL cholesterol levels reduces the risk of cardiovascular disease.…”

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confidence: 99%

“…LFO contains flavonoids, and its major component is glabridin. 1) Thus, further study is necessary to clarify the effect of LFO flavonoids, including glabridin, on HMGS levels in high-fat diet rats.…”

mentioning

confidence: 99%

Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

Honda

Saneyasu

Hasegawa

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Investigation of the Anti-Obesity Action of Licorice Flavonoid Oil in Diet-Induced Obese Rats

Cited by 66 publications

References 39 publications

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Enhancement of Fat Oxidation by Licorice Flavonoid Oil in Healthy Humans during Light Exercise

Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

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