Measurement of Coronary Blood Flow by the Nitrous Oxide Method

Eckenhoff, James E.; Hafkenschiel, Joseph H.; Harmel, Merel H.; Goodale, Walter T.; Lubin, Martin; Bing, Richard J.; Kety, Seymour S.

doi:10.1152/ajplegacy.1948.152.2.356

Cited by 139 publications

(29 citation statements)

References 0 publications

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“…The normal perfusion pattern determined in these subjects agrees closely with several studies in experimental animals in which regional myocardial blood-flow measurements were made with 86Rb or radioactive microspheres.5 1 Currently, several investigators are exploring techniques that measure regional myocardial blood flow with Anger scintillation camera (single crystal with multihole collimation). This scintillation camera has demonstrated the capacity to localize visually the deficits in myocardial perfusion; however, its effectiveness in the quantitative measurements of regional rates of myocardial blood flow will await further study.…”

supporting

confidence: 79%

Regional Myocardial Blood Flow

Dwyer¹

1972

Circulation

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supporting

confidence: 79%

Regional Myocardial Blood Flow

Dwyer¹

1972

Circulation

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“…rate in the left ventricle, 64.1 +13.9 ml/100 gamin, sigPrevious investigators have: (a) monitored either nificantly exceeded that in the right ventricle, 47.8 ±10.9 the single washout curve of an inert gas injected into ml/100 gamin, and that in the right atrium, 33.6 ±10.3 a coronary artery (11,14,16,28) or the myocardial ml/100 g*min.…”

Section: Resultsmentioning

confidence: 99%

“…This approach, an extension of a technique previously developed in the dog (10), consists of the injection of 'Xe selectively into a coronary artery and the external measurement of isotope wash-out curves from multiple discrete regions of the myocardium with a multiple-crystal scintillation camera. The method simultaneously measures the rate constants of "'Xe washout from multiple FIGURE 1 Schematic diagram illustrating the sequential steps involved in measurement of regional myocardial blood flow with AXe and a multiple-crystal scintillation camera. areas of the heart instead of attempting to resolve a single multiexponential myocardial wash-out curve as has been done previously (11)(12)(13)(14)(15)(16). Data obtained by this new technique in 17 patients with normal coronary arteries are presented.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Regional Myocardial Perfusion in Man with 133Xenon and a Scintillation Camera

Cannon¹,

Dell²,

Dwyer³

1972

J. Clin. Invest.

120

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A B S T R A C T A method was devised to quantitate regional capillary perfusion in the human heart by measuring the clearance constants (k) of Xenon-133 washout from multiple areas of the myocardium with a multiple-crystal scintillation camera. In 17 subjects, "'Xe was injected into the right or left coronary artery or both and counts per second (cps) were recorded simultaneously on magnetic tape from each of 294 scintillation crystals viewing the precordium through a multichannel collimator. Data were processed by a digital computer. Crystals detecting the myocardial washout of 'Xe were distinguished from those monitoring pulmonary excretion by positioning radioactive markers at the cardiac margins, and by a computer printout of the peak cps recorded by each crystal and its time after isotope injection into the coronary artery. The slopes of the initial segment of the multiple "'Xe curves obtained in each study were calculated by the method of least squares using a monoexponential model. Myocardial blood flow rates in the cardiac regions viewed by the individual crystals were calculated (assuming a blood to myocardium partition coefficient of 0.72) along with the SD of every flow measurement. The pattern of myocardial perfusion rates so obtained was superimposed over a tracing of the subject's coronary arteriogram. Scintiphotographs showing the arrival and washout of isotope from various regions of myocardium and the area of tissue perfused by each coronary artery were obtained by replaying the data tape on an oscilloscope. Significant regional variations in local myocardial perfusion rates were observed in hearts with normal coronary arteries.

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“…Cardiac output was determined by the Fick principle, coronary blood flow by the nitrous oxide saturation method utilizing a blood-myocardial partition coefficient of 1 (15). Pressures were recorded with Statham strain gauges and the direct writing Sanborn poly-viso.…”

Section: Methodsmentioning

confidence: 99%