Regional Myocardial Blood Flow

Dwyer, Edward M.

doi:10.1161/01.cir.45.1.4

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…This is in agreement with the findings of Cowan et al (15) (2,4,7,33). AMore recently, however, Klocke and his collaborators (3) have used a hydrogen desaturation method in which attention is paid to the crucial importance, because of heterogeneous flow, of delivery method, sampling period, and precision of measuring technique.…”

Section: Detailed Findings Are Presented Insupporting

confidence: 90%

Total and effective coronary blood flow in coronary and noncoronary heart disease.

Mymin¹,

Sharma²

1974

J. Clin. Invest.

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A B S T R A C T There are no data available concerning total coronary blood flow to the whole heart (CBF) in man. "Effective" or "nutrient" coronary blood flow to the whole heart (MBF), supposedly a measure of flow through exchanging channels of the coronary circulation, has been measured but its validity has not been established. Accordingly, CBF and MBF were measured in 9 normal subjects, 26 patients with coronary heart disease (CHD), and 19 with noncoronary, mostly valvular heart disease (NCHD), by coincidence counting 'Rb technique. Two methods were used: single bolus (24 cases) and continuous infusion (30 cases). Various other parameters including myocardial oxygen utilization (MVO2) and lactate extraction ratio were determined.In the normal subjects CBF (386±77 ml/min) was significantly higher (P < 0.05) than in CHD (288±+124 ml/min) and NCHD (292±111 ml/min). Likewise the normal MBF (380±81 ml/min) was significantly higher (P < 0.01) than in CHD (251±105 ml/min) as well as NCHD (258±+104 ml/min). The myocardial Rb extraction ratio (ERb) was significantly lower in normal subjects (39±9%) than in CHD (50±7%) and NCHD

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Section: Detailed Findings Are Presented Insupporting

confidence: 90%