Measurement Area and Repeatability of Semiautomated Assessment of Corneal Endothelium in the Topcon Specular Microscope SP-2000P and IMAGEnet System

Ding, Xiaohu; Huang, Qunxiao; Zheng, Yingfeng; Jiang, Yuzhen; Huang, Shengsong; He, Mingguang

doi:10.1097/ico.0b013e31820e42b5

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…The Topcon SP2000P has the ability to measure ECD, HEX, and CV. The mechanism of the Topcon SP2000P has already been described in other studies, 23 and the repeatability 27 and validity 28 of the Topcon SP2000P have previously been reported. As for the results of the Topcon SP2000P, the system monitors the entire process automatically and then presents acceptable measurements.…”

Section: Methodsmentioning

confidence: 53%

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Ostadimoghaddam

Sedaghat

Rakhshandadi

et al. 2018

Journal of Current Ophthalmology

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PurposeThe aim of this study was to analyze and compare corneal endothelial cell morphology and characteristics in bilateral keratoconus (KCN) patients with unilateral Vogt's striae.MethodsFifty patients aged 20–38 years were recruited in this cross-sectional contralateral eye study. In this study, corneal endothelial cell parameters were evaluated in patients with bilateral KCN and unilateral Vogt's striae using the Topcon SP2000P specular microscope (Topcon, Tokyo, Japan).ResultsIn the current study, there were no significant differences in corneal endothelial cell parameters including endothelial cell density (ECD), hexagonal cell ratio (HEX), and coefficient of variance of cell size (CV) between the KCN groups with and without Vogt's striae, [(2968.34 ± 276.65 vs. 2980.05 ± 253.30, P = 0.618), (51.88 ± 13.57 vs. 53.24 ± 9.31, P = 0.658), and (32.50 ± 5.40 vs. 32.97 ± 4.07, P = 0.467), respectively]. Also, among study groups with and without Vogt's striae, ECD did not correlate with anterior chamber depth (ACD) [(P = 0.564, r = 0.09), (P = 0.219, r = −0.18), respectively], maximum keratometry (Kmax) [(P = 0.215, r = 0.18), (P = 0.898, r = 0.02), respectively], and central corneal thickness (CCT) [(P = 0.989, r = −0.02), (P = 0.643, r = −0.07), respectively].Our results showed significant differences in corrected and uncorrected distance visual acuity (UDVA), cycloplegic refractive error components (calculated by vectorial analysis), CCT, and Kmax between two study groups (all P < 0.05) except for J45 (Jackson cross cylinder, axes at 45 and 135°) (P = 0.131).ConclusionsWe were not able to find the statistically significant differences in ECD, HEX, and CV between KCN eyes with and without Vogt's striae. Despite clinical and tomographic results, it seems that Vogt's striae cannot cause deterioration in the corneal endothelial morphology.

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Section: Methodsmentioning

confidence: 53%

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Ostadimoghaddam

Sedaghat

Rakhshandadi

et al. 2018

Journal of Current Ophthalmology

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“…), all measurements were performed with the same specular microscope used prior to implantation, and all measurements were performed using the same protocol, cutting out most variation that can be induced by changing surgeons or measurement methods. [25][26][27][28] ENDOTHELIAL CELL DENSITY: We calculated the percentage of total EC loss and the percentage of total EC loss corrected for an annual physiological loss of 0.6% by using the results of the mixed-model linear regression analyses. 22,23 After 6 months, the acute EC loss in the myopic and toric groups was similar to the 0.05% to 4.3% short-term EC loss after 6 months reported in the literature, 1,3,29 with 0.7% and 1.6% of eyes showing a decrease in ECD > _ 25% after uncomplicated surgery, respectively (data on file).…”

Section: Despite the Multitude Of Anterior Chamber Piolsmentioning

confidence: 99%

Five-Year Endothelial Cell Loss After Implantation With Artiflex Myopia and Artiflex Toric Phakic Intraocular Lenses

Jonker

Berendschot

Ronden

et al. 2018

American Journal of Ophthalmology

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“…Specular microscopy is used as a selection criteria for cataract surgery in humans to evaluate and quantify corneal endothelial cells . However, in veterinary medicine, specular microscopy has been reported only in the scope of investigative ophthalmology .…”

Section: Introductionmentioning

confidence: 99%

Intraocular pressure, specular microscopy, and prostaglandinE₂concentration in dogs with mature and hypermature cataract

Renzo

Ribeiro

Silva

et al. 2014

Veterinary Ophthalmology

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This study aimed to evaluate and correlate intraocular pressure (IOP), endothelial cell density (CD), and hexagonality (HEX), and the aqueous humor prostaglandin E2 (PGE2 ) concentration in dogs with mature (MG, n = 8) and hypermature (HG, n = 8) cataracts. Eight laboratory beagles with no ocular abnormalities were included as a control group (CG). The IOP was measured using a digital applanation tonometer. Noncontact specular microscopy was used to evaluate CD and HEX. Samples of aqueous humor were used to determine prostaglandin E2 concentration using enzyme-linked immunoassay. Data were compared by anova and Bonferroni's multiple comparison test, and possible correlations among the PGE2 aqueous concentration and corneal endothelium cell parameters were assessed by Person's test (P < 0.05). Average values of IOP (P = 0.45) and CD (P = 0.39) were not significantly different between MG, HM, and CG. Average values of HEX were lower, and PGE2 concentration was increased in the MG and HG in comparison with CG (P < 0.05); however, such parameters did not change significantly between MG and HG (P > 0.05). PGE2 values did not correlate with IOP, CD, and HEX in any group (P > 0.05). Although there were a small number of dogs studied, our results demonstrated that cataract progression from mature to hypermature did not have a significant change in PGE2 aqueous concentration, IOP, corneal endothelial cell count, or morphology. In addition, PGE2 concentration was not correlated with parameters of the corneal endothelium or IOP in dogs with mature or hypermature cataracts.

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Measurement Area and Repeatability of Semiautomated Assessment of Corneal Endothelium in the Topcon Specular Microscope SP-2000P and IMAGEnet System

Abstract: Repeatability is improved when larger measurement areas are chosen.

Cited by 12 publications

References 21 publications

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Five-Year Endothelial Cell Loss After Implantation With Artiflex Myopia and Artiflex Toric Phakic Intraocular Lenses

Intraocular pressure, specular microscopy, and prostaglandinE₂concentration in dogs with mature and hypermature cataract

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Measurement Area and Repeatability of Semiautomated Assessment of Corneal Endothelium in the Topcon Specular Microscope SP-2000P and IMAGEnet System

Abstract: Repeatability is improved when larger measurement areas are chosen.

Cited by 12 publications

References 21 publications

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

A contralateral eye study comparing characteristics of corneal endothelial cells in bilateral keratoconus patients with unilateral corneal Vogt's striae

Five-Year Endothelial Cell Loss After Implantation With Artiflex Myopia and Artiflex Toric Phakic Intraocular Lenses

Intraocular pressure, specular microscopy, and prostaglandinE2concentration in dogs with mature and hypermature cataract

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Intraocular pressure, specular microscopy, and prostaglandinE₂concentration in dogs with mature and hypermature cataract