Measurement and modeling of epicatechin solubility in supercritical carbon dioxide fluid

Soetaredjo, Felycia Edi; Ismadji, Suryadi; Ju, Yi‐Hsu

doi:10.1016/j.fluid.2012.12.005

Cited by 15 publications

(4 citation statements)

References 37 publications

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“…At static condition, the recovery of catechin from activated carbon was only 1.2% while for epicatechin it was 14.5%. This low recovery is consistent with the solubility data of both phenolic compounds in supercritical CO 2 under static condition [30,31]. In order to increase the recovery of catechin and epicatechin in supercritical CO 2 , dynamic extraction experiments were also conducted with flow rates of CO 2 from 0.1 to 1 kg/h.…”

Section: Recover Of Phenolic Compounds In Sago Waste Effluentsupporting

confidence: 83%

“…The recovery of catechin and epicatechin from activated carbon was performed by supercritical CO 2 at 313.15 K and 26 MPa under static and dynamic conditions. Details about the supercritical system can be found elsewhere [30]. At static condition, the recovery of catechin from activated carbon was only 1.2% while for epicatechin it was 14.5%.…”

Section: Recover Of Phenolic Compounds In Sago Waste Effluentmentioning

confidence: 99%

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Recovery of catechin and epicatechin from sago waste effluent: Study of kinetic and binary adsorption isotherm studies

Soetaredjo

Ismadji

Santoso

et al. 2013

Chemical Engineering Journal

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. Recovery of catechin and epicatechin from sago waste effluent. Supercritical CO 2 desorption of catechin and epicatechin from activated carbon. Adsorption of catechin and epicatechin in binary system. a r t i c l e i n f o b s t r a c tThe recovery of valuable phenolic compounds (catechin and epicatechin) from sago waste effluent by activated carbon adsorption was studied in this work. Single and binary component of catechin and epicatechin was studied in static mode using synthetic effluent. Langmuir model was applied to evaluate the adsorption equilibrium data in single system. In binary system, the modified extended Langmuir model by inclusion of surface coverage was used to represent the adsorption data. All experimental data were well represented either by Langmuir model or its modified form. For kinetic study, it was found that pseudo-second order model represents the experimental data better than pseudo-first order model. Adsorption study using real sago waste effluent indicated that activated carbon adsorption process is promising for recovery of valuable phenolic compounds. Supercritical CO 2 extraction of phenolic compounds from activated carbon resulted in low recovery. The addition of ethanol as co-solvent significantly enhanced the desorption of catechin and epicatechin from activated carbon.

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Section: Recover Of Phenolic Compounds In Sago Waste Effluentsupporting

confidence: 83%

Section: Recover Of Phenolic Compounds In Sago Waste Effluentmentioning

confidence: 99%

Recovery of catechin and epicatechin from sago waste effluent: Study of kinetic and binary adsorption isotherm studies

Soetaredjo

Ismadji

Santoso

et al. 2013

Chemical Engineering Journal

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“…Hitherto, researches that performed on solubility modeling of drug compounds are rare. [8][9][10][11][12][13][14][15][16] Benzamide is used for making trimethobenzamide that treats nausea and vomiting related to surgery or caused by stomach flu. It is also used to study the mechanism of photocatalytic decomposition of aqueous solutions of acetic acid, acetamide and acetonitrile in the presence of semiconductors.…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies, different modelings were performed for solubility correlation of quercetin, mefenamic acid, sulindac, spironolactone, epicatechin, carvedilol and other solid compounds in supercritical CO 2 using different equations of state. [8][9][10][11][12][13][14][15][16] As there are various thermodynamic models and equations of state for the estimation of solid solubility in supercritical fluids, it is important to present an approach with fewer adjustable parameters.…”

Section: Introductionmentioning

confidence: 99%

A thermodynamic approach for correlating the solubility of drug compounds in supercritical CO2 based on Peng-Robinson and Soave-Redlich-Kwong equations of state coupled with van der Waals mixing rules

Setoodeh

Darvishi

Ameri

2019

JSCS

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In the present study, the effect of equations of state and mixing rules in a thermodynamic approach has been investigated for the correlation of the solubility of four new solid pharmaceutical compounds, namely, benzamide, cetirizine, metaxalone and niflumic acid in supercritical CO 2 at different temperatures and pressures. Two equations of state, the Peng-Robinson (PR) and Soave-Redlich-Kwong (SRK), coupled with mixing rules of one-parameter van der Waals (vdW1) and two-parameter van der Waals (vdW2) were used, where the binary interaction parameters for these sets of equations were evaluated. The approach correlations and the robustness of the numerical technique were validated with the experimental data previously reported for these compounds at different temperatures and pressures. The calculated average absolute relative deviations (AARD) were 7.51 and 5.31 % for PR/vdW1 and PR/ /vdW2 couples, and 11.05 and 10.24 % for SRK/vdW1 and SRK/vdW2 couples, respectively. It was also found that the PR equation of state results in modeling performance better than the SRK equation, and the vdW2 mixing rule better than the vdW1 one. These results obviously demonstrate that the combined approach used in this study is applicable for correlation of solid solubilities of some pharmaceutical compounds in supercritical CO 2. Additionally, a semiempirical correlation is proposed for estimating the solubility of drug solids in supercritical CO 2 as a function of pressure and temperature.

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Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Sodeifian

Usefi

2022

ChemBioEng Reviews

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Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC‐CO2 is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi‐empirical, and intelligence models to establish suitable correlations. SC‐CO2 is one of the most important materials used in SCFs to study solubility. Another application of SC‐CO2 is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC‐CO2. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC‐CO2 in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

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Measurement and modeling of epicatechin solubility in supercritical carbon dioxide fluid

Cited by 15 publications

References 37 publications

Recovery of catechin and epicatechin from sago waste effluent: Study of kinetic and binary adsorption isotherm studies

Recovery of catechin and epicatechin from sago waste effluent: Study of kinetic and binary adsorption isotherm studies

A thermodynamic approach for correlating the solubility of drug compounds in supercritical CO2 based on Peng-Robinson and Soave-Redlich-Kwong equations of state coupled with van der Waals mixing rules

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

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