Mean platelet volume as a marker for differentiating disease flare from infection in Behçet's disease

Ryu, Hee Jung; Seo, Mi Ryoung; Choi, Hyo Jin; Ko, Kwang Pil; Park, Pil Whan; Baek, Han Joo

doi:10.1111/1756-185x.13008

Cited by 8 publications

(6 citation statements)

References 45 publications

(49 reference statements)

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“…It has been reported that MPV is decreased in BD patients than in healthy control, regardless of clinical activity. 33‐36 In our study, although the MPV value showed no difference between RAS and control, it was significantly lower in patients with inactive BD compared with the other two groups. Although the cause of decreased MPV was not elucidated in studies, Jiang et al emphasised that MPV alone cannot be a suitable indicator of platelet activation since there is no clear correlation between platelet aggregation responses and platelet indexes 33,37 .…”

Section: Discussioncontrasting

confidence: 57%

“…Also, non-identical technical factors such as blood sampling, and collection methods can also affect the MPV value. 36,57 These situations have been neglected in most of the studies. Whereas, firstly, we constituted three groups adjusted for possible confounders.…”

Section: Discussionmentioning

confidence: 99%

“…Hemogram parameters can be affected by many variables such as age, gender to iron deficiency, drug use, smoking, altitude and accompanying comorbidities. Also, non‐identical technical factors such as blood sampling, and collection methods can also affect the MPV value 36,57 . These situations have been neglected in most of the studies.…”

Section: Discussionmentioning

confidence: 99%

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Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis – A single centre, prospective, case‐control study

et al. 2021

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Recurrent oral ulcers (ROUs) are the most common disorder of the oral cavity in the community. Although many etiological causes such as trauma, genetic, nutritional, infectious, immune, drug-mediated, rheumatological, endocrinological have a role, it is commonly idiopathic, known as recurrent aphthous stomatitis (RAS). 1-3 Indeed, RAS has accounted for 25% of oral ulcers in adults and 40% in children. 2 The most challenging issue for the clinician to deal with in the diagnosis is to distinguish whether oral ulcers are associated with primarily Behçet's disease (BD) and other systemic inflammatory processes such as inflammatory bowel diseases and connective

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis – A single centre, prospective, case‐control study

et al. 2021

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“…80 Numerous studies found a negative correlation between MPV and autoimmune disease activity. 81–83 In Behçet’s disease, for example, MPV decreased during disease exacerbation and rose during infection in same subjects. 81 These results emphasise the close interaction between thrombosis and inflammation by pointing to a relationship between low MPV values and chronic inflammation.…”

Section: Discussionmentioning

confidence: 98%

The prognostic value of mean platelet volume in patients with coronary artery disease: a systematic review with meta-analyses

Galimzhanov,

Naung Tun,

Sabitov

et al. 2024

Preprint

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Background: Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admission MPV in predicting clinical outcomes in patients with CAD. Methods: PubMed, Web of Science, and Scopus were the major databases used for literature search. The risk of bias was assessed using the quality in prognostic factor studies. We used random-effects pairwise analysis with the Knapp and Hartung approach supported further with permutation tests and prediction intervals (PIs). Results: We identified 52 studies with 47066 patients. A meta-analysis of 9 studies with 14,864 patients demonstrated that 1 femtoliter increase in MPV values was associated with a rise of 29% in the risk of long-term mortality (hazard ratio (HR) 1.29, 95% confidence interval (CI) 1.22-1.37) in CAD as a whole. The results were further supported with PIs, permutation tests and leave-one-out sensitivity analyses. MPV also demonstrated its stable and significant prognostic utility in predicting long-term mortality as a linear variable in patients treated with percutaneous coronary intervention (PCI) and presented with acute coronary syndrome (ACS) (HR 1.29, 95% CI 1.20-1.39, and 1.29, 95% CI 1.19-1.39, respectively). Conclusion: The meta-analysis found robust evidence on the link between admission MPV and the increased risk of long-term mortality in patients with CAD patients, as well as in patients who underwent PCI and patients presented with ACS.

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“…Differently, Ryu et al . [ 26 ] reported that MPV was significantly lower in patients with BD compared to controls and claimed that MPV may be useful as a marker of BD activity. According to the results of this study, MPV, PDW, and PCT levels were significantly higher in active and inactive ocular BD patients than controls.…”

Section: Discussionmentioning

confidence: 99%

Platelet activation in ocular Behçet's patients with posterior segment involvement

Çıtırık

Özdal

Keles

et al. 2021

Middle East Afr J Ophthalmol

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PURPOSE: The aim of the present study was to assess platelet activation by analyzing three platelet activation parameters in ocular Behçet's disease (BD): mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). METHODS: Twenty-nine patients with active ocular BD (Group 1), 40 patients with inactive ocular BD (Group 2), and 40 healthy adult individuals serving as controls (Group 3) were evaluated. All of the individuals had been performed the complete ophthalmologic evaluation. The levels of MPV, PDW, and PCT were measured in each group. RESULTS: The mean MPV level was 8.40 ± 0.97 in Group 1, 8.32 ± 1.04 in Group 2, and 7.77 ± 0.72 in Group 3. The mean PDW level was 15.12 ± 1.09 in Group 1, 14.97 ± 1.02 in Group 2, and 14.52 ± 0.82 in Group 3. The mean PCT level was 0.23 ± 0.07 in Group 1, 0.21 ± 0.04 in Group 2, and 0.18 ± 0.03 in Group 3. MPV, PDW, and PCT levels were significantly higher in ocular BD patients than controls ( P < 0.05). CONCLUSION: Platelet activation may affect vascular occlusion in ocular Behçet's patients with posterior segment involvement. This result may be important in evaluating ocular BD patients.

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Mean platelet volume as a marker for differentiating disease flare from infection in Behçet's disease

Abstract: MPV was significantly lower in patients with BD than controls. MPV declined in BD flare and increased in cases of infection in same patients. MPV may be useful as a marker of BD activity and its monitoring can be helpful for differentiating BD flare from infection in BD patients.

Cited by 8 publications

References 45 publications

Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis – A single centre, prospective, case‐control study

Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis – A single centre, prospective, case‐control study

The prognostic value of mean platelet volume in patients with coronary artery disease: a systematic review with meta-analyses

Platelet activation in ocular Behçet's patients with posterior segment involvement

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