Mean Platelet Volume as a Marker of Intraventricular Hemorrhage in Very Premature Infants

Mosayebi, Ziba; Sepidarkish, Mahdi; Nikseresht, Zahra; Sharifi, Mohammad Reza; Sagheb, Setareh; Nariman, Shahin

doi:10.5812/ijp.8322

Cited by 3 publications

(19 citation statements)

References 28 publications

(28 reference statements)

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“…Our results regarding the Gestational age and body weight was against Mosayebi et al, [20] who study Markers of Intraventricular Hemorrhage in Very Premature Infants. One hundred premature infants with gestational age (GA) < 34 weeks divided into two groups, infants with IVH had lower birth weight (Mean difference: 0.48, 95%CI: 0.08 to 0.87, P = 0.018) and GA (Mean difference: 2.9, 95%CI: 1.95 to 3.92, P < 0.001), compared to infants without IVH.…”

Section: Discussionsupporting

confidence: 44%

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Ashraf

El-Sheikh

El-Mashad

2021

AJPR

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Background: Preterm infants with Intra-Ventricular Hemorrhage (IVH) are at risk for developing significant complications, including post hemorrhagic hydrocephalus and seizures. Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn, and is associated with short- and long-term adverse effects. Objective: The aim of the study is to evaluate the value of Peripheral Neutrophil- lymphocyte ratio (NLR) as a predictor of seizure in preterm infants with intra-ventricular hemorrhage. Methods: This prospective cohort study that comprised 60 Preterm infants with IVH admitted at NICU pediatric department Tanta university hospital from November 2019 to May 2020, Preterm infants were divided into two groups according to incidence of seizure. Preterm infants in this study subjected to Careful history taking, clinical examination and investigations (laboratory and Trans-cranial ultrasound) as well as analysis of result and follow up clinical status for development of seizure. Results: There was a statistically highly significant difference regarding NLR and development of seizure with p value <0.001 (NLR ≥ 2.3 with sensitivity 96%, specificity 93%, Area under the curve 0.849 and accuracy 84.9%). Conclusion: NLR is a predictor of seizure in preterm infants with intra-ventricular hemorrhage.

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Section: Discussionsupporting

confidence: 44%

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Ashraf

El-Sheikh

El-Mashad

2021

AJPR

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“…11 fl), Mosayebi et al and Hussein et al showed a significant association with IVH. 15,26 Other Platelet Indices Platelet mass index is calculated as platelet count Â MPV and was investigated in three studies. 13,14,27 Two studies showed a lower platelet mass index at days 3 to 7 13,14 in neonates with IVH than in neonates without IVH.…”

Section: Platelet Countmentioning

confidence: 99%

“…15,26 Mosayebi et al reported an adjusted odds ratio of 10.68 (95% CI: 3.20-35.59) for having IVH when MPV was > 11 fl. 15 However, the wide CI reflects a considerable uncertainty of the estimate. Altered MPV has been suggested as a consequence of inflammation due to IVH rather than a cause of IVH.…”

Section: Mean Platelet Volumementioning

confidence: 99%

“…13,14 Mean platelet volume (MPV) has been suggested to change due to inflammation induced by IVH, 13,15 and potentially other conditions, with investigations on MPV as an early marker for IVH having been reported. [13][14][15][16] Some studies described higher MPV in neonates with IVH, 15,16 whereas others found no significance of MPV. 13,14 These conflicting results stress the need to elucidate whether platelet indices have an essential role in the early risk assessment of IVH.…”

mentioning

confidence: 99%

“…Studies investigating platelet count as a categorical variable (n ¼ 9)< 150 Â 10 9 /L Mosayebi et al, 201715 TP, IVH vs. non-IVH 70 vs. 20% (p ¼ 0.041) 9.3 (3.7-23.4) NR Ryckman et al, 2011 28 TP, IVH vs. non-IVH 42.8 vs. 12.5% (p ¼ 0.11) 5.3 (0.8-36.0) NR Szpecht et al, 2017 22 TP, IVH 2-4 vs. IVH 0-1 45.16 vs. 17.39% (p ¼ 0.034) 3.9 (1.5-10.0) NR : CI, confidence interval; NR, not reported; NS, not significant; OR, odds ratio; TP, thrombocytopenia. IVH, intraventricular hemorrhage (Papile grade 1-4).…”

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confidence: 99%

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The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

Grevsen

Hviid

Hansen

et al. 2019

Semin Thromb Hemost

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Intraventricular hemorrhage (IVH) affects up to 22% of extremely low birth weight neonates. Impaired coagulation might contribute to the pathogenesis of IVH. The aims of this study were to summarize the current knowledge on the role of platelet indices in premature neonates with IVH and to provide an overview of secondary hemostasis parameters as well as fibrinolysis in premature neonates with IVH. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Embase, Scopus, and Web of Science were searched on March 7, 2019, without time restrictions. In total, 30 studies were included. Most studies investigated the significance of platelet counts and/or mean platelet volume (MPV). The meta-analysis showed that at day 1 of life, neither platelet count nor MPV differed significantly between neonates with or without IVH (standardized mean difference [SMD]: –0.15 × 109/L, 95% confidence interval [CI]: –0.37 to 0.07 and SMD: 0.22 fl, 95% CI: –0.07 to 0.51, respectively). However, platelet counts < 100 × 109/L were associated with an increased risk of IVH. Secondary hemostasis parameters did not differ between neonates with and without IVH. Fibrinolysis was only sparsely investigated. In conclusion, platelet counts < 100 × 109/L were associated with an increased risk of IVH in premature neonates. The impact of secondary hemostasis was only sparsely investigated but seemed to be minor, and the role of fibrinolysis in IVH in premature neonates needs further research. Whether reduced platelet function is associated with an increased risk of IVH in premature neonates remains to be investigated.

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The relationship between mean platelet volume (MPV) and intraventricular hemorrhage in very low birth weight infants

Sadeghzadeh,

Khoshnevisasl,

Fallah

et al. 2023

NPM

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BACKGROUND: Intra ventricular hemorrhage (IVH) is a major cause of mortality among very low birth weight infants. This study aimed to investigate the relationship between mean platelet volume (MPV) and IVH in very low birth weight infants. METHOD: In this cohort study, all premature infants weighing less than 1500 grams who were admitted to the NICU were enrolled from August 2018 to July 2019. Brain ultrasonography was performed on the first and seventh days and one month of age and were compared with Platelet count and MPV. RESULTS: From 183 neonates, 23 cases (12.6%) had IVH. The mean MPV on the first day in the group with IVH was 10.48±0.85 and in the non-IVH group was 9.9±0.74 (P = 0.005). The mean MPV on the seventh day in the IVH and non-IVH group were 10.4±0.92 and 10.03±0.74 (P = 0.04) respectively. On the first and seventh day, for one unit of MPV increase, the chance of IVH increased by 2.68 and 2.1 respectively. (p = 0.001; OR3.643; 95% CI [1.703–7.753]). CONCLUSION: The mean MPV index is significantly higher in the infants with IVH and therefore it can be used in early detection of IVH in neonates weighing less than 1500 grams.

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Mean Platelet Volume as a Marker of Intraventricular Hemorrhage in Very Premature Infants

Cited by 3 publications

References 28 publications

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

Peripheral Neutrophil- Lymphocyte Ratio as a Predictor of Seizure in Preterm Infants with Intra-Ventricular Hemorrhage

The Role of Platelets in Premature Neonates with Intraventricular Hemorrhage: A Systematic Review and Meta-Analysis

The relationship between mean platelet volume (MPV) and intraventricular hemorrhage in very low birth weight infants

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