Background Phototherapy (PT) is the most often utilized technique for treating and preventing severe hyperbilirubinemia in the term and preterm newborns. PT's proven benefit is that it decreases the requirement for exchange transfusions. To investigate the effect of PT on allergic response mediators in neonates with hyperbilirubinemia treated by PT, eosinophil counts and tumor necrosis factor alfa levels have been assessed. Methods This cross-sectional study included 100 full-term infants with indirect hyperbilirubinemia in the first two weeks of life who were indicated for PT. They were investigated by tumor necrosis factor α and eosinophil counts before and 72 h after starting PT. The used tests were paired with Student’s t-test and Pearson coefficient. Results Relative and absolute eosinophil counts and tumor necrosis factor alfa were significantly higher after PT than before (p < 0.001). There was a significant positive correlation between total serum bilirubin and both tumor necrosis factor alfa and eosinophil % (r = 0.442 and r = 0.362, respectively, P < 0.001) before PT. There was a significant positive correlation between total serum bilirubin and both eosinophil count and eosinophil % (r = 0.281and r = 0.339), respectively (P < 0.001) after PT. There was a significant positive correlation between both tumor necrosis factor alfa and eosinophil % after PT (r = 0.545, P < 0.001). Conclusions Serum tumor necrosis factor-alpha and eosinophilic count increased after treatment of neonatal hyperbilirubinemia by PT, which indicates an allergic response to PT in neonates.
Background Ventilator‐associated pneumonia (VAP) is one of the most common causes of nosocomial pneumonia in ventilated neonates. Nevertheless, its diagnosis is challenging due to the nonspecific clinical parameters and the lack of sensitive biomarkers. The main objective of this study was to compare soluble triggering receptors expressed on myeloid cells‐1 (sTREM‐1) and 25‐hydroxy vitamin D as early predictors of neonatal VAP. Methods This prospective cohort study included 85 ventilated neonates divided into the VAP group (n = 33) and the non‐VAP group (n = 52). sTREM‐1 levels in the endotracheal aspirate (ETA) and serum 25‐hydroxy vitamin D levels were measured on the third and seventh days following mechanical ventilation. The Ethical and Research Committee approved the study at Tanta University Hospitals, Egypt (with the Approval code: 32751/12/18). Results The sTREM‐1 cutoff value of >0.46 and >0.44 ng/ml at 3 and 7 days had a sensitivity of 93.94% and 96.97%, a specificity of 92.31% and 100%, and an area under the receiver operating characteristic curve (AUC) of 0.963 and 0.993, respectively, to predict the development of neonatal VAP. A serum 25‐hydroxy vitamin D cutoff value of ≤17.5 ng/ml at 3 and 7 days had a sensitivity of 90.91% and 81.82%, a specificity of 75% and 78.85%, and area under the curve of 0.877 and 0.939, respectively. Conclusion Both sTREM‐1 in ETA and serum 25‐hydroxy vitamin D could be used as early predictors of neonatal VAP, but sTREM‐1 appears more useful.
Background: Sepsis is one of the most encountered pathologies in the neonatal intensive care unit and is associated with significant morbidity and mortality. Prematurity and low birth weight are the most important neonatal factors predisposing to infection. Many infants with sepsis develop cardiovascular instability, especially preterm. The role of Functional echocardiography for the evaluation of hemodynamic status in sick newborns is limited by the need for a trained provider. Methods: this is a quasi-experimental study that aimed at proving the efficacy of Electrical Cardiometry in hemodynamic status in septic preterm neonates. 80 septic preterm neonates with gestational ages between (34 0/7 to 36 6/7) weeks admitted to the Tanta University neonatal intensive care unit and met the criteria for diagnosis of neonatal sepsis were enrolled. A control group of 80 matched newborns for gestational age and sex were included. Bedside Echocardiography assessment was performed together with bedside electrical cardiometry monitoring in 1st, 2nd, 3rd days of sepsis manifestations and before discharge. Data for Statistical analysis was fed to the computer and analyzed using IBM SPSS software package version 20.0. (Armonk, NY: IBM Corp). The Kolmogorov-Smirnov test was used to verify the normality of distribution Quantitative data were described using range (minimum and maximum), mean, standard deviation, median and interquartile range (IQR). The significance of the obtained results was judged at the 5% level. Results: Stroke volume, cardiac output and cardiac index measurements by both echocardiography and electrical cardiometry were significantly higher in 2nd readings compared to last readings in sepsis group and in comparison, to control group. Correlations between electrical cardiometry and echo were positive as regard stroke volume 2nd readings, cardiac output 2nd readings and cardiac index 2nd readings in both groups. Conclusion: Electrical cardiometry can be recommended as a useful tool for hemodynamics assessment in late preterm neonates with sepsis.
Background: Neonatal brain injury (NBI) is a serious adverse outcome in premature neonates. The most common form of neonatal brain injury (NBI) are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). Improved survival of preterm infants leads to short- and long-term hazards of neurological, cognitive, respiratory, digestive, renal, cardiovascular, metabolic, immune, and psychosocial disturbances. We sought to determine the levels and prognostic value of serum S100B and the role of aEEG during the first three days of life in premature neonates (< 37 weeks) that later developed NBI in the form of intraventricular hemorrhage (IVH) or neonatal seizures to rule out the sensitivity and specificity of them in early detection of brain lesions in preterm neonates. Aim of the Study: To evaluate the role of Protein S100B as an early predictor for neonatal brain injury in preterm neonates and the predictive and prognostic value of amplitude-integrated electroencephalography for neonatal brain injury susceptibility and severity. Subject and Methods: This study was carried out on 50 preterm neonate (less than 37 weeks GA) who were divided according to presence or absence of brain injury into case and control groups. They were admitted in Neonatal Intensive Care Unit (NICU) of Tanta University Hospital during the period from March 2021 to March 2022.serum S100B at (Day 1 and Day 3), serial trans-cranial sonar and aEEG were done for all patients. Results: Neonates with NBI, had significantly higher S100B concentration during the first three days of life, its level was higher in the third day than the first day, the cut-off value >810.4 ng/ml serum S100B performed a sensitivity of 72.7%and a specificity of 71.4% to predict adverse neonatal outcome. 60% neonates had normal aEEG and 40% had abnormal aEEG.72.7% of neonates with NBI had abnormal aEEG interpretation. There was a significant relationship between the electrografic seizures on aEEG and occurrence of clinical seizures as 96.7% of neonates who had abnormal aEEG suffered of clinical convulsion. Conclusion: Protein S100B has a good predictive value regarding NBI in premature neonates and aEEG has a great role in monitoring neonatal brain function and early detection of neonatal seizures.
Background: Preterm infants with Intra-Ventricular Hemorrhage (IVH) are at risk for developing significant complications, including post hemorrhagic hydrocephalus and seizures. Neonatal seizures are the most common overt manifestation of neurological dysfunction in the newborn, and is associated with short- and long-term adverse effects. Objective: The aim of the study is to evaluate the value of Peripheral Neutrophil- lymphocyte ratio (NLR) as a predictor of seizure in preterm infants with intra-ventricular hemorrhage. Methods: This prospective cohort study that comprised 60 Preterm infants with IVH admitted at NICU pediatric department Tanta university hospital from November 2019 to May 2020, Preterm infants were divided into two groups according to incidence of seizure. Preterm infants in this study subjected to Careful history taking, clinical examination and investigations (laboratory and Trans-cranial ultrasound) as well as analysis of result and follow up clinical status for development of seizure. Results: There was a statistically highly significant difference regarding NLR and development of seizure with p value <0.001 (NLR ≥ 2.3 with sensitivity 96%, specificity 93%, Area under the curve 0.849 and accuracy 84.9%). Conclusion: NLR is a predictor of seizure in preterm infants with intra-ventricular hemorrhage.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.