Eosinophil count and tumor necrosis factor α in response to phototherapy treatment of neonatal hyperbilirubinemia: a cross sectional study

El-Sheikh, Mai Rabie; Ahmed, Amira Youssef; El-Mashad, Abd El-Rahman Mohamed; Talaye, Ibrahim Ibrahim; El-Hawary, Eslam El-Sayed

doi:10.1186/s13052-022-01302-w

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Immune and Inflammatory/Childhood Allergies Allergic reactions appear to be increased in infants exposed to phototherapy for treatment of hyperbilirubinemia. 12,13,14,15,16 Although the study by Das and Neike 12 was found to be of low quality, the consistency of the evidence for this adverse effect among all five studies included in this review, appears to indicate that children with a history of neonatal phototherapy immune should be screened for immune and inflammatory/childhood allergies during regular pediatric visits as a potential adverse effect of the neonatal phototherapy they received. There are not findings that consistently demonstrate causation of the adverse effects stemming from phototherapy versus hyperbilirubinemia versus a combination of the two.…”

Section: Discussionmentioning

confidence: 93%

“…There was a significant positive correlation found by El Sheikh between total serum bilirubin and both eosinophil count and eosinophil % (r = 0.281and r = 0.339), respectively (P < 0.001) after PT. 13 A significant positive correlation was also found between both tumor necrosis factor alfa and eosinophil % after PT (r = 0.545, P < 0.001) 13 . The increased serum tumor necrosis factor-alpha and eosinophilic count following neonatal phototherapy indicates an allergic response.…”

Section: Immune or Inflammatory/childhood Allergiesmentioning

confidence: 92%

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Neonatal Phototherapy Adverse Effects in Infants: A Scoping Review

Mendelson¹

2023

MRAJ

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Objective: To determine what adverse effects of neonatal phototherapy have been identified and the general breadth of the research. Data Sources: A search for relevant sources was conducted using PubMed, The Cochrane Database, Ovid, and Clinical Key via EBSCO Discovery Search from January 2013-January 2023. Study Selection: Sources were included if participants had undergone phototherapy for hyperbilirubinemia during their first weeks of life, including term and preterm infants. Twenty-three sources met the inclusion criteria. Data Extraction: Extraction included citation, design, context, aim, participants, outcomes, and main results. Data Synthesis: General concepts leading the synthesis included adverse effects of neonatal phototherapy. In addition, specific subgroups of adverse effects explored included childhood allergies, childhood cancers, patent ductus arteriosus (PDA), migraine headaches, attention deficit hyperactivity disorder, autism spectrum disorder, eye disorders and acoustic disorders. Conclusion: While the quality of studies varies, more rigorous research on adverse effects of neonatal phototherapy would benefit from careful selection of methods and reference standards, direct measures of each adverse outcome identified in adults and children, and prospective cohort studies linking early neonatal exposure with each adverse outcome outcomes throughout childhood and adolescence. Elucidating the effects of hyperbilirubinemia versus neonatal phototherapy on each potential adverse outcome will help to determine if new treatment methods for infants with hyperbilirubinemia need to be developed.

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Section: Discussionmentioning

confidence: 93%

Section: Immune or Inflammatory/childhood Allergiesmentioning

confidence: 92%

Neonatal Phototherapy Adverse Effects in Infants: A Scoping Review

Mendelson¹

2023

MRAJ

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“…(9,42,43,44). Recent studies have shown that phototherapy is responsible for DNA damage, oxidative stress, and proin ammatory cytokine release (30,32,37). Hence, this vulnerable population is prone to photo-oxidative side effects of phototherapy.…”

Section: Discussionmentioning

confidence: 99%

Acute Biochemical alterations during Phototherapy of Neonatal Icterus: Systematic Review and Meta-analysis

Chaudhari

Gawli

Kumar

et al. 2023

Preprint

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Purpose Phototherapy is used in the treatment of neonatal hyperbilirubinemia. There are contravening reports on its its adverse effect. This meta-analysis was conducted to substantiate the impact of phototherapy on the parameters indicating oxidative stress and proinflammatory cytokines. Methods The relevant clinical studies were searched on PubMed, Google Scholar, Stanford University High-Wire Press, Clinical trial registry, and on Semantic Scholar published up to 30th July 2022. Newcastle-Ottawa Scale was used to assess the study qualities. The overall estimate was calculated in terms of odds ratio with 95% confidence interval using random effect model. The sensitivity and subgroup analysis were carried out along with the qualitative assessment of the publication bias. All the analysis was carried out using RevMan 5. Results Total 1735 participants from 31 pertinent studies were used for the quantitative analysis. The pooled estimates of the phototherapy-exposed group were compared with the control group. Our analysis revealed that phototherapy used in treating neonatal jaundice induced significant oxidative stress and increased the levels of inflammatory cytokines. Overall estimate measure i.e., mean difference was found to be significant [1.39 (0.79 1.99)] for MDA (nmol per ml), [-0.87 (-1.35 -0.39)] for MDA (nmol per litre) [-0.25 (-0.34 -0.15)] for TAC, [-81.68 (-105.50 -57.85)] for TNF-α, and non-significant for TOS and IL-6 i.e [1.36(-2.67 5.39)] and [1.96 (-0.89 4.81)] respectively Conclusion Therapeutic exposure to phototherapy in treating neonatal jaundice induces a rise in oxidative stress and inflammatory cytokine levels. The short and long-term clinical outcomes may have clinical significance.

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Effect of phototherapy on eosinophils count in neonatal hyperbilirubinemia (cross-sectional study)

Tarek,

Mosallam,

Saber

et al. 2023

Egypt Pediatric Association Gaz

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Background Neonatal jaundice is a common disorder in neonates. Phototherapy is associated with various side effects despite being safe. This research aimed to determine the impact of phototherapy (PT) on eosinophil levels in neonates treated for unconjugated hyperbilirubinemia. Methods In this cross-sectional prospective study, icteric neonates admitted to the Neonatal Intensive Care Unit (NICU) of Abo-Elreesh Child Hospital, Cairo University, from July 2020 to June 2021 were assessed. Laboratory data, including serum bilirubin and blood cell differentiation for eosinophils before and after phototherapy, were collected, and demographic data like age, gender, gestational age, and duration of phototherapy were taken. Results Two hundred neonates were included in this study. Hyperbilirubinemia was most frequently related to ABO group incompatibility (44.5%). After phototherapy, total serum bilirubin and neutrophil levels were significantly decreased, and platelet levels were significantly increased. Eosinophil count and percent were significantly increased (p < 0.001) following phototherapy. A statistically significant positive correlation was found between eosinophil count before and after PT (r = 0.583, p < 0.001) and between eosinophil percent before and after PT (r = 0.617, p < 0.001). Conclusion Serum eosinophils were increased after phototherapy in icteric neonates with hyperbilirubinemia.

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Eosinophil count and tumor necrosis factor α in response to phototherapy treatment of neonatal hyperbilirubinemia: a cross sectional study

Cited by 3 publications

References 20 publications

Neonatal Phototherapy Adverse Effects in Infants: A Scoping Review

Neonatal Phototherapy Adverse Effects in Infants: A Scoping Review

Acute Biochemical alterations during Phototherapy of Neonatal Icterus: Systematic Review and Meta-analysis

Effect of phototherapy on eosinophils count in neonatal hyperbilirubinemia (cross-sectional study)

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