Meal frequency patterns determine the phase of mouse peripheral circadian clocks

Kuroda, Hiroaki; Tahara, Yu; Saito, Keisuke; Ohnishi, Naofumi; Kubo, Yohei; Seo, Yasuhiro; Otsuka, Makiko; Fuse, Yuta; Ohura, Yuki; Hirao, Akiko; Shibata, Shigenobu

doi:10.1038/srep00711

Cited by 99 publications

(90 citation statements)

References 36 publications

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“…An elegant study examined the effects of consuming 2, 3, 4, or 6 equally spaced meals over 24-h in mice [104]. By necessity, mice were calorically restricted by 20% during this period, to ensure all food was eaten within discrete time periods.…”

Section: Considerations When Designing Reduced Meal Frequency Diets mentioning

confidence: 99%

Metabolic impacts of altering meal frequency and timing – Does when we eat matter?

Hutchison

Heilbronn

2016

Biochimie

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Section: Considerations When Designing Reduced Meal Frequency Diets mentioning

confidence: 99%

Metabolic impacts of altering meal frequency and timing – Does when we eat matter?

Hutchison

Heilbronn

2016

Biochimie

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“…Furthermore, another group reported differences in the diurnal expression of clock genes in the liver of chronically alcohol-fed mice (Filiano et al, 2013), a finding broadly consistent with our studies. Furthermore, it is known that adaptation of peripheral clocks is dependent on the time of feeding, meal frequency pattern, and metabolic state (Kuroda et al, 2012). However, currently there are few studies systematically characterizing the feeding and locomotor activity patterns in mice chronically fed with the Lieber-DeCarli diet.…”

Section: Introductionmentioning

confidence: 99%

Dissociation between diurnal cycles in locomotor activity, feeding behavior and hepatic PERIOD2 expression in chronic alcohol-fed mice

Zhou

Werner

Lee

et al. 2015

Alcohol

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Chronic alcohol consumption contributes to fatty liver disease. Our studies revealed that the hepatic circadian clock is disturbed in alcohol-induced hepatic steatosis, and effects of chronic alcohol administration upon the clock itself may contribute to steatosis. We extended these findings to explore the effects of chronic alcohol treatment on daily feeding and locomotor activity patterns. Mice were chronically pair-fed ad libitum for 4 weeks using the Lieber-DeCarli liquid diet, with calorie-controlled liquid and standard chow diets as control groups. Locomotor activity, feeding activity, and real-time bioluminescence recording of PERIOD2::LUCIFERASE expression in tissue explants were measured. Mice on liquid control and chow diets exhibited normal profiles of locomotor activity, with a ratio of 22:78% day/night activity and a peak during early night. This pattern was dramatically altered in alcohol-fed mice, marked by a 49:51% ratio and the absence of a distinct peak. While chow-diet fed mice had a normal 24:76% ratio of feeding activity, with a peak in the early night, this pattern was dramatically altered in both liquid-diet groups: mice had a 43:57% ratio, and an absence of a distinct peak. Temporal differences were also observed between the two liquid-diet groups during late day. Cosinor analysis revealed a ~4-h and ~6-h shift in the alcohol-fed group feeding and locomotor activity rhythms, respectively. Analysis of hepatic PER2 expression revealed that the molecular clock in alcohol-fed and control liquid-diet mice was shifted by ~11 h and ~6 h, respectively. No differences were observed in suprachiasmatic nucleus explants, suggesting that changes in circadian phase in the liver were generated independently from the central clock. These results suggest that chronic alcohol consumption and a liquid diet can differentially modulate the daily rhythmicity of locomotor and feeding behaviors, aspects that might contribute to disturbances in the circadian timing system and development of hepatic steatosis.

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“…The liver can easily adapt to a new feeding time in about 3 days, and the balance between food intake and starvation periods sets the phase. Eating at night shortens the starvation period causing phase alterations in peripheral clocks [103,104] . A well-balanced diet may induce a rapid phase shift in the liver clock: a combination of carbohydrate and protein is effective, while protein, sugar, or oil is not [103,105] .…”

Section: Chrononutritionmentioning

confidence: 99%

White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies

2016

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A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.

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Meal frequency patterns determine the phase of mouse peripheral circadian clocks

Cited by 99 publications

References 36 publications

Metabolic impacts of altering meal frequency and timing – Does when we eat matter?

Metabolic impacts of altering meal frequency and timing – Does when we eat matter?

Dissociation between diurnal cycles in locomotor activity, feeding behavior and hepatic PERIOD2 expression in chronic alcohol-fed mice

White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity: Pathogenesis and Available Therapies

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