MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus

Lima, Guadalupe; Soto‐Vega, Elena; Atisha‐Fregoso, Yemil; Sánchez‐Guerrero, Jorge; Vallejo, Maité; Vargas‐Alarcón, Gilberto; Llórente, Luis

doi:10.1016/j.humimm.2007.10.007

Cited by 43 publications

(39 citation statements)

References 32 publications

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“…Amplification of the SDF-1 3' UTR was carried out using primers described by Lima et al (2007). The 20-µL amplification reaction contained 10 ng genomic DNA, 2 µL 10X Taq buffer with 500 mM KCl, 1.5 mM MgCl 2 , 0.075 mM dNTP mixture, 0.375 µM each for forward and reverse primers, and 0.75 U Taq DNA polymerase.…”

Section: Amplification Of the Sdf-1 Genementioning

confidence: 99%

“…It is also known as CXCL12, which was originally identified as a growth factor for murine pre-B cells (Ye et al, 2005b). SDF-1 plays an important role in the regulation of migration, proliferation, differentiation of hematopoetic cells, as well as being involved in the homeostatic and inflammatory traffic of leukocytes (Lima et al, 2007). The receptor for SDF-1 is CXCR4, and interaction between SDF-1 and its receptor plays a vital role in CD4 + T-cell accumulation in the synovium in patients with rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

“…SDF-1 is also known to inhibit activation-induced apoptosis of T-cells (Ye et al, 2005b). This condition can lead to production of pathogenic autoantibodies (Lima et al, 2007). An SNP was found in the 3' UTR of the SDF-1 gene at position 801 (Lima et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…This condition can lead to production of pathogenic autoantibodies (Lima et al, 2007). An SNP was found in the 3' UTR of the SDF-1 gene at position 801 (Lima et al, 2007). The polymorphism is characterized by a G to adenine (A) variation that can increase the transcriptional activity of the SDF-1 gene, resulting in production of larger quantities of SDF-1 proteins (Ye et al, 2005b).…”

Section: Introductionmentioning

confidence: 99%

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Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lh¹,

Kee²,

Hl³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC-and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR of the SDF-1 gene at position 801, in 130 patients presenting SLE at the Malaya University Medical Centre. Screening of 130 healthy volunteer controls using RFLP was also performed. RANTES-28 polymorphism analysis showed no significant (P = 0.3520) relationship, even though homozygous C/C was more frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent in healthy controls (OR = 0.7051). There were no significant (P = 0.2650) associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289) genotypes in the SDF-1 gene polymorphism with SLE. We conclude that there is no significant association of RANTES-28 and SDF-1 gene polymorphisms and occurrence of SLE in Malaysia.

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Section: Amplification Of the Sdf-1 Genementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lh¹,

Kee²,

Hl³

et al. 2011

Genet. Mol. Res.

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“…Proteinuria was reduced and survival was prolonged in an MCP-1-deficient MRL-lpr mouse model, suggesting that this gene has an important function in lupus nephritis. 177 The rs1024611 (À2518A/G) SNP of MCP-1 was positively associated with SLE susceptibility in Caucasians 178,179 and Mexicans 180 but not in Spaniards, 181,182 African Americans, 178 Koreans, 183,184 Japanese 185 and Chinese.…”

mentioning

confidence: 98%

Genetic studies of systemic lupus erythematosus in Asia: where are we now?

Kim

et al. 2009

Genes Immun

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There have been many genetic studies of systemic lupus erythematosus (SLE) in Asia, but the status of SLE in Asia remains unclear. Genes that have been associated with SLE in Caucasians have shown both consistent and inconsistent results in Asians. This prompted us to review studies of SLE-associated genes and compare the degree of consistency according to ethnicity in Asia. We searched PubMed and the national databases in Korea and Japan for SLE genetic studies. A total of 755 articles were found and after applying various exclusion criteria, 442 studies including 17 linkage studies, 2 genome-wide association studies and 423 candidate-gene analyses were reviewed. Nine linkage loci were confirmed to be associated with SLE susceptibility in non-Asians, but the risk locus (16q12) has been identified in only one Asian study. A total of 156 candidate genes were analyzed, of which 92 were studied in Asians. Although there were allelic (HLA-DRB1 and IRF5) or genetic heterogeneity (FCGR gene family), HLA-DRB1, the FCGR gene family, IRF5, STAT4 and MECP2 showed consistent associations with SLE susceptibility across ethnicities. In conclusion, genetic associations often vary with ethnicity, requiring validation in different ethnic groups, and hence future SLE genetic studies will require strong worldwide collaborations.

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CCL2 in the Tumor Microenvironment

O'Connor

Heikenwälder

2021

Advances in Experimental Medicine and Biology

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MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus

Cited by 43 publications

References 32 publications

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Genetic studies of systemic lupus erythematosus in Asia: where are we now?

CCL2 in the Tumor Microenvironment

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