Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lh, Lian; Kee, Boon Pin; Hl, Ng; Chua, Kek Heng

doi:10.4238/2011.november.17.2

Cited by 11 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But on the other hand, our results matched studies by Ye et al, Warchol et al, and Lian LH who had genotyped the CXCL12-3′G801A polymorphism in Chinese, Poland, and Malaysian subjects, respectively, and found no association of CXCL12-3′G801A polymorphism with SLE (Ye et al 2005;Warchol et al 2010;Lian et al 2011).…”

Section: Discussionsupporting

confidence: 92%

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

et al. 2015

View full text Add to dashboard Cite

SDF-1(CXCL12) is a chemokine that plays an important role in the regulation of migration, proliferation, and differentiation of hematopoietic cells, as well as being involved in the homeostatic and inflammatory traffic of leukocytes. It was suggested that CXCL12 is a key molecule in the development of autoimmunity in the murine model of lupus. It has been demonstrated that SDF-1 has a G801A transition at position 801 in the 3′-untranslated region of the transcript, known as SDF-1-3′G801A. This polymorphism may have an important regulatory function via an increase in the biosynthesis of SDF-1 protein and has been reported in association with autoimmune diseases, such as type 1 diabetes and systemic sclerosis. We investigated the prevalence of SDF-1-3′ G801A genotype in Egyptian patients with systemic lupus erythematosus (SLE) (n=50) and healthy controls (HC) (n= 50) and its relation to SLE manifestations. We found a significant correlation between the SDF-1-3′G801A genotype and the following SLE features: photosensitivity, nephritis, serositis, and vasculitis, and also anticardiolipin antibodies. Our observations suggest that the SDF-1-3′-G801A genotype may be associated with some clinical and laboratory manifestations in patients with SLE.

show abstract

Section: Discussionsupporting

confidence: 92%

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Of the remaining publications, 4 review articles and 3 papers with republished data were further excluded. Therefore, we selected 5 eligible publications [ 9 , 10 – 13 ] on the basis of rigorous inclusion criteria. Among these studies, 3 [ 9 , 10 , 13 ] were carried out in Asians, 1 [ 12 ] focused on Caucasians, and 1 [ 11 ] was involved in Mexican Mestizos.…”

Section: Resultsmentioning

confidence: 99%

Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk

2017

View full text Add to dashboard Cite

ObjectivePresent meta-analysis was performed to investigate the role of stromal cell-derived factor (SDF-1) gene rs1801157 polymorphism in systemic lupus erythematosus (SLE).ResultsFive publications with 1,087 cases and 1,181 controls were incorporated in this meta-analysis. Overall, a marginal association between SDF-1 rs1801157 polymorphism and reduced SLE risk was found under GA vs. GG model (OR = 0.84, 95% CI = 0.70–1.00). A similar result was also observed in Asian subgroup under the same comparison after stratification analysis by ethnicity (OR = 0.79, 95% CI = 0.63–1.00).Materials and MethodsAll included studies were retrieved from PubMed, EMBASE, Google Scholar Web and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to appraise the strength of association between SDF-1 rs1801157 polymorphism and SLE risk. The stratification analysis was also performed according to ethnicity. In addition, heterogeneity was examined with Q test, and sensitivity analysis was used to test the stability of final results. Begg’s funnel plot and Egger’s test were adopted to evaluate publication bias.ConclusionsSDF-1 rs1801157 polymorphism may not influence the risk of SLE. However, more studies with larger sample sizes involving different populations are needed to further explore this issue.

show abstract

“…Some of the important target genes such as C4, C1q, CTLA-4, IL-6, IL-1, RANTES-28, and SDF-1 have been studied previously in the Malaysian population (Puah et al, 2007;Chew et al, 2008;Chua et al, 2009aChua et al, ,b, 2010Lian et al, 2011); however, most of them were found to have no major significant association with SLE susceptibility. Hence in this study, we aimed to target and investigate the distribution of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) dimorphism and its potential association to the susceptibility of SLE.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients

Lian¹,

Lau²,

Ching³

et al. 2012

Genet. Mol. Res.

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE development, severity and prognosis. We investigated a possible association between the angiotensin-converting enzyme gene and susceptibility to SLE in the Malaysian population. PCR was employed for the determination of I/D dimorphism of this gene. The I allele was more frequent than the D allele in both the SLE patients (N = 170) and healthy controls (N = 190). However, there was no significant difference in the distribution of these two alleles between both groups studied (χ 2 = 0.284, P > 0.05). Interestingly, the DD homozygous genotype scored notably higher in the healthy control group (χ 2 = 7.568, P < 0.05), while the ID heterozygote was observed to be significantly associated with SLE (χ 2 = 11.143, P < 0.05). In conclusion, with respect to the Malaysian population, the DD genotype might play a protective role in the development of SLE while in contrast, those who carry the ID genotype might be at potential risk for onset of this disease.

show abstract

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Cited by 11 publications

References 33 publications

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk

Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients

Contact Info

Product

Resources

About