MCM3 as a Novel Diagnostic Marker in Benign and Malignant Salivary Gland Tumors

Jaafari‐Ashkavandi, Zohreh; Najvani, Ali Dehghani; Tadbir, Azadeh Andishe; Pardis, Soheil; Ranjbar, Mohammad Ali; Ashraf, Mohammad Javad

doi:10.7314/apjcp.2013.14.6.3479

Cited by 39 publications

(50 citation statements)

References 21 publications

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“…Recently, a study has shown an expression of MCM3, a proliferation marker in SGT by immunohistochemical analysis with 74.3% sensitivity and 93.3% specificity between malignant and benign SGT. 31 A recent study on the expression of SPAG9 has predicted presence of malignant endometrium with 74% sensitivity, 83% specificity, 88% PPV, and 64.5% NPV. 32 In our study, SPAG9 protein expression in IHC predicted presence of malignant SGT with 83.72% sensitivity, 100% specificity, 100% PPV, and 83.72% NPV.…”

Section: Discussionmentioning

confidence: 99%

Sperm associated antigen 9(SPAG9) expression and humoral response in benign and malignant salivary gland tumors

et al. 2014

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Keywords: biomarker, cancer testis antigen, early detection and diagnosis, immunotherapeutic target, SPAG9Salivary gland cancers are highly aggressive epithelial tumor associated with metastatic potential and high mortality. The tumors are biologically diverse and are of various histotypes. Besides, the detection and diagnosis is a major problem of salivary gland cancer for available treatment modalities. In the present study, we have investigated the association of sperm associated antigen 9 (SPAG9) expression with salivary gland tumor (SGT). Clinical specimens of benign (n D 16) and malignant tumors (n D 86) were examined for the SPAG9 expression. In addition, the sera and adjacent non-cancerous tissues (n D 72) from available patients were obtained. Our in situ RNA hybridization and immunohistochemistry (IHC) analysis revealed significant difference (p D 0.0001) in SPAG9 gene and protein expression in benign (63%) and malignant tumor (84%) specimens. Further, significant association was also observed between SPAG9 expression and malignant tumors (P D 0.05). A cut-off value of >10% cells expressing SPAG9 protein designated as positive in IHC, predicted presence of malignant SGT with 83.72% sensitivity, 100% specificity, 100% PPV and 83.72% NPV. Humoral response against SPAG9 protein was generated in 68% of SGT patients. A cut-off value of 0.212 OD for anti-SPAG9 antibodies in ELISA predicted presence of malignant SGT with 69.23% sensitivity, 100% specificity, 100% PPV and 78.94% NPV. Collectively, our data suggests that the majority of SGT show significant difference and association among benign and malignant tumors for SPAG9 gene and protein expression and also exhibit humoral response against SPAG9 protein. Hence, SPAG9 may be developed as a biomarker for detection and diagnosis of salivary gland tumors.

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Section: Discussionmentioning

confidence: 99%

Sperm associated antigen 9(SPAG9) expression and humoral response in benign and malignant salivary gland tumors

et al. 2014

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“…They also suggest that MCM-3 expression is a more sensitive marker of proliferation than Ki-67 expression in case of salivary gland epithelial tumors, such as pleomorphic adenomas, mucoepidermoid carcinomas, and adenoid cystic carcinomas, in adults [24].…”

Section: Discussionmentioning

confidence: 98%

A case of intraparotid schwannoma in a juvenile: Clinical, pathological, ultrastructural, and immunohistopathological study, including an examination of Ki-67 and MCM-3 expressions

Zielinski

Kobos

Zakrzewska

2016

Ultrastructural Pathology

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Pleomorphic adenoma, the most common benign nonvascular tumor of the parotid gland in juveniles, should be differentiated from other extremely rare tumors, including schwannoma. In this article, we present a rare case of an intraparotid schwannoma in a juvenile, along with the patient history, a description of pathological features, and the results of ultrastructural and immunohistochemical examination. The respective labeling indexes of Ki-67 and MCM-3, i.e., the mean proportions of positive tumor cells out of 1000 tumoral cells counted in 10 microscopic fields at ×400 magnification, given as a percentage, were found to be 0.82% and 0.4%, respectively.

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“…But most research mainly concentrated in the laboratory research (Tadbir et al, 2012;Ashkavandi et al, 2013;Jaafari et al, 2013), rarely used for guiding clinical therapy at present (Iqbal et al, 2014). Current views of clinical study for effect of ACC chemotherapy is not consistent, the choice of chemotherapy plan is difference.…”

Section: Discussionmentioning

confidence: 99%

Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells

Ding²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, lung, breast, skin and lacrimal gland. Chemotherapy is one of the key treatment techniques, but drug resistance, especially MDR, seriously blunts its effects. As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins.

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MCM3 as a Novel Diagnostic Marker in Benign and Malignant Salivary Gland Tumors

Cited by 39 publications

References 21 publications

Sperm associated antigen 9(SPAG9) expression and humoral response in benign and malignant salivary gland tumors

Sperm associated antigen 9(SPAG9) expression and humoral response in benign and malignant salivary gland tumors

A case of intraparotid schwannoma in a juvenile: Clinical, pathological, ultrastructural, and immunohistopathological study, including an examination of Ki-67 and MCM-3 expressions

Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells

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