Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells

Abstract

Background: Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, lung, breast, skin and lacrimal gland. Chemotherapy is one of the key treatment techniques, but drug resistance, especially MDR, seriously blunts its effects. As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins.

A novel CpG island methylation panel predicts survival in lung adenocarcinomas

“…However, limited data had been acquired on their functional roles in cancer biology. RPL39L was identified to confer drug resistance in lacrimal gland adenoid cystic carcinoma (43) and the lung cancer A549 cell line (44), but others have not been fully characterized in cancer. Future functional investigation of these genes will assist in developing understanding of the biological implications of the CGI methylation signature of the present study, and for identifying promising epigenetic therapeutic targets in lung ADCs.…”

Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes

“…Single-copy X-chromosome-linked genes shared between human and mouse are expressed predominantly in the testis with low frequency as well as autosomal genes [2]. However, on the Xq24 and XqA3.3 regions, there are several single-copy genes expressed in the testis [1,[15][16][17][18][19][20][21][22]. Furthermore, multi-copy genes such as CT47 and Rhox families are also predominantly expressed in the testis, although some Rhox genes are homologs of human single-copy RHOXF1 and RHOXF2 [1].…”