A case of intraparotid schwannoma in a juvenile: Clinical, pathological, ultrastructural, and immunohistopathological study, including an examination of Ki-67 and MCM-3 expressions

Abstract

Pleomorphic adenoma, the most common benign nonvascular tumor of the parotid gland in juveniles, should be differentiated from other extremely rare tumors, including schwannoma. In this article, we present a rare case of an intraparotid schwannoma in a juvenile, along with the patient history, a description of pathological features, and the results of ultrastructural and immunohistochemical examination. The respective labeling indexes of Ki-67 and MCM-3, i.e., the mean proportions of positive tumor cells out of 1000 tumoral cells counted in 10 microscopic fields at ×400 magnification, given as a percentage, were found to be 0.82% and 0.4%, respectively.

Sporadic neurofibroma of facial nerve presenting as parotid gland tumor: a rare case report

“…FNAC is commonly used as an initial diagnostic tool for IGN [ 12 ]. The results from FNAC can provide valuable information regarding the cytological features of the tumor, helping to differentiate it from other parotid gland tumors [ 13 ].…”

Diagnostic Significance of Ki67 Staining Pattern in Benign Peripheral Nerve Sheath Tumors: An Additional Diagnostic Tool

“…1 Ki-67 is an immunohistochemical marker staining the cells in S, G2, or M phases of the cell cycle. 3 It is widely used in numerous neoplasms including the nerve sheath tumors and predicts the potential aggressiveness by designating the proliferation rate of the tumor. [4][5][6] However, in the scope of Ki-67 immunohistochemistry, there are very few studies which prefer to analyze the staining pattern rather than the proliferative score.…”