MC3T3-E1 cell response of amorphous phase/TiO2 nanocrystal composite coating prepared by microarc oxidation on titanium

Zhou, Rui; Wei, Daqing; Yang, Haoyue; Feng, Wei; Cheng, Su; Li, Baoqiang; Wang, Yaming; Jia, Dechang; Zhou, Yu

doi:10.1016/j.msec.2014.03.006

Cited by 23 publications

(12 citation statements)

References 55 publications

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“…The osteoblast response on oxide layer coatings formed using the PEO process is not yet clearly understood, but in our previous research, the largest number of cells was also found for coatings formed in solutions with wollastonite on the Ti-15Mo alloy surface[22]. It was reported that high concentrations of Si in the coatings could have a similar influence on the cell response as the high concentration of Ca[23]. Our results are similar.…”

supporting

confidence: 85%

Biofunctionalization of Ti–13Nb–13Zr alloy surface by plasma electrolytic oxidation. Part II

Kazek-Kęsik

Krok-Borkowicz

Jakóbik‐Kolon

et al. 2015

Surface and Coatings Technology

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supporting

confidence: 85%

Biofunctionalization of Ti–13Nb–13Zr alloy surface by plasma electrolytic oxidation. Part II

Kazek-Kęsik

Krok-Borkowicz

Jakóbik‐Kolon

et al. 2015

Surface and Coatings Technology

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“…This could be related to the effect of the chemical composition on the MAO coating. 28 The cell adhesion ratio on pTiMAO is lower than that on Ti-MAO, which is probably due to the effect of the macroporous structure as mentioned above. However, it is found that the cell adhesion ratio on pTiMAO is higher than that on pTi.…”

Section: Discussionmentioning

confidence: 91%

“…The previous results indicate that the effect of the chemical composition of the MAO coatings on MC3T3-E1 cell attachment is pronounced. 28 The addition of Ca and Si elements on the surface of Ti by MAO or other surface modification methods such as ion implantation could give rise to a specially altered surface charge, which could further influence cell attachment. 27 Thus, attachment of the MC3T3-E1 cells on the Ti-MAO sample was prolonged compared to that of the Ti sample based on this and previous research.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 99%

Structure, MC3T3-E1 Cell Response, and Osseointegration of Macroporous Titanium Implants Covered by a Bioactive Microarc Oxidation Coating with Microporous Structure

Zhou

Wei

Cheng

et al. 2014

ACS Appl. Mater. Interfaces

Self Cite

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Macroporous Ti with macropores of 50-400 μm size is prepared by sintering Ti microbeads with different diameters of 100, 200, 400, and 600 μm. Bioactive microarc oxidation (MAO) coatings with micropores of 2-5 μm size are prepared on the macroporous Ti. The MAO coatings are composed of a few TiO2 nanocrystals and lots of amorphous phases with Si, Ca, Ti, Na, and O elements. Compared to compact Ti, the MC3T3-E1 cell attachment is prolonged on macroporous Ti without and with MAO coatings; however, the cell proliferation number increases. These results are contributed to the effects of the space structure of macroporous Ti and the surface chemical feature and element dissolution of the MAO coatings during the cell culture. Macroporous Ti both without and with MAO coatings does not cause any adverse effects in vivo. The new bone grows well into the macropores and micropores of macroporous Ti with MAO coatings, showing good mechanical properties in vivo compared to Ti, MAO-treated Ti, and macroporous Ti because of its excellent osseointegration. Moreover, the MAO coatings not only show a high interface bonding strength with new bones but also connect well with macroporous Ti. Furthermore, the pushing out force for macroporous Ti with MAO coatings increases significantly with increasing microbead diameter.

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“…8E, F). Many previous studies on osteoblast behaviors have shown that after 7-day culture, the ability of osteoblast differentiation and mineralization become obvious [40, 41]. In this study, protein expressions of Runx2 and OSX were significantly higher on Ti-SLA, Ti-NW and Ti-NW-Zn surfaces than those on cp-Ti surface after 7-day culture, indicating that Ti-SLA, Ti-NW and Ti-NW-Zn surfaces could all enhance the osteogenic differentiation, especially the Ti-NW-Zn surface, reflecting the good biocompatibilities.…”

Section: Resultsmentioning

confidence: 99%

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Zhu

Shao

et al. 2019

J Nanobiotechnol

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Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H 2 O 2 . Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.

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MC3T3-E1 cell response of amorphous phase/TiO2 nanocrystal composite coating prepared by microarc oxidation on titanium

Cited by 23 publications

References 55 publications

Biofunctionalization of Ti–13Nb–13Zr alloy surface by plasma electrolytic oxidation. Part II

Biofunctionalization of Ti–13Nb–13Zr alloy surface by plasma electrolytic oxidation. Part II

Structure, MC3T3-E1 Cell Response, and Osseointegration of Macroporous Titanium Implants Covered by a Bioactive Microarc Oxidation Coating with Microporous Structure

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

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