Maximal thymectomy in children with myasthenia gravis

Essa, Mohamed A.; El-Medany, Yasser; Hajjar, Waseem; Hariri, Zohair; Al-Mulhim, Faisal; Salih, Mustafa A.; Ashour, Mahmoud; Alkattan, Khaled

doi:10.1016/s1010-7940(03)00299-9

Cited by 25 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A poor response to thymectomy in patients with ectopic thymic tissue has been documented. 13 Timing may also influence the response to thymectomy. Improved remission rates and less severe final disease have been described in cases with earlier thymectomy.…”

Section: Discussionmentioning

confidence: 99%

Myasthenia gravis in Jamaican children: a 12-year institutional review

Chambers

Forrester

Gray

et al. 2012

Paediatrics and International Child Health

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Myasthenia gravis in Jamaican children: a 12-year institutional review

Chambers

Forrester

Gray

et al. 2012

Paediatrics and International Child Health

View full text Add to dashboard Cite

show abstract

“…Ashour and colleagues also reported two cases of re-exploration due to postoperative bleeding, 6 cases of pulmonary complications, and 2 cases of septicemia in 48 patient without any mortality 14. In the following report, however, they experienced no complications in 30 pediatric patients 15. Both authors reported no recurrent laryngeal or phrenic nerve injury.…”

Section: Discussionmentioning

confidence: 75%

“…Theoretically, a more radical resection of ectopic thymic tissue results in a larger decrease in the antigenic focus for autoimmune disease, therefore maximal thymectomy is regarded as the most effective method of thymectomy 4,8. Some studies have provided more promising results 8,15. However, comparison of the prognostic value of various methods of thymectomy is difficult at present, because almost all these studies were conducted in a retrospective setting and used subjective parameters for end points with inappropriate statistical analysis methods 2,8.…”

Section: Discussionmentioning

confidence: 99%

Transsternal Maximal Thymectomy is Effective for Extirpation of Cervical Ectopic Thymic Tissue in the Treatment of Myasthenia Gravis

Lee

Yang

et al. 2008

Yonsei Med J

View full text Add to dashboard Cite

PurposeExtensive extirpation of cervico-mediastinal adipose tissue increases the chance of removing ectopic thymic tissues, thus potentially improving the prognosis of myasthenia gravis after thymectomy. We sought to increase efficacy and safety of transsternal maximal thymectomy (TSMT).Materials and MethodsTwenty four patients who underwent TSMT from July 2006 to June 2007 were retrospectively reviewed and compared with 73 patients who underwent transsternal extended thymectomy (TSET) from January 2004 to May 2006. Ectopic thymic tissue in additionally excised cervicomediastinal fat tissue was examined histologically.ResultsIn TSMT group, operation time, amount of cumulative drainage and duration of drainage were significantly higher than TSET group. However, the difference in hemoglobin count, amount of transfusion, duration of intensive care, postoperative hospital stay, and complication rates were not statistically different. There was no operative mortality in either group. Ectopic thymic tissue was found in 50% of patients. All patients had ectopic thymic tissues in the cervical area. Two patients had additional ectopic tissue in the aortopulmonary window, and 1 patient had ectopic tissue at posterior of the left bracheocephalic vein and lateral of the right phrenic nerve.ConclusionTSMT is more effective in the extirpation of ectopic thymic tissues than TSET without significant impairment of safety, especially in the cervical area.

show abstract

“…The natural course of MG in children remains largely undetermined and because of the rarity of the disease in this age group, the consensus on the benefit of thymectomy is still unclear, hence a satisfactory evaluation of thymectomy has been difficult to achieve [14]. Although most of the data are for the adult group, thymectomy appears to provide a high rate of remission and improvement in children with MG [2,7]. In our cases with a long duration of symptoms and thymoma, the disease does not seem to follow a very benign course and thymectomy did not modify the clinical evolution.…”

Section: Discussionmentioning

confidence: 99%

Juvenile Limb-Girdle Myasthenia Gravis

Rodolico¹,

Pastura²,

Sinicropi³

et al. 2005

Neuropediatrics

View full text Add to dashboard Cite

Limb-girdle myasthenia is a rare disorder which includes familial and autoimmune forms. Myasthenia gravis is an uncommon disease in children and its diagnosis may be difficult. We report here five cases of autoimmune juvenile LGM starting before the age of 16 years with attention to clinical diagnostic difficulties, evolution, laboratory and instrumental data as well as response to treatment. Diagnosis of limb-girdle myasthenia requires a strong index of suspicion also in childhood. We suggest that this form be suspected in children with unclassifiable myopathy, mostly affecting deltoid muscles and lower extremities.

show abstract

Maximal thymectomy in children with myasthenia gravis

Abstract: Maximal thymectomy appears to provide a high rate of remission and improvement in children with MG. However, the presence of ectopic thymic tissue has poor prognostic value.

Cited by 25 publications

References 17 publications

Myasthenia gravis in Jamaican children: a 12-year institutional review

Myasthenia gravis in Jamaican children: a 12-year institutional review

Transsternal Maximal Thymectomy is Effective for Extirpation of Cervical Ectopic Thymic Tissue in the Treatment of Myasthenia Gravis

Juvenile Limb-Girdle Myasthenia Gravis

Contact Info

Product

Resources

About