Myasthenia gravis in Jamaican children: a 12-year institutional review

Chambers, Rachel M.; Forrester, Shawnia; Gray, R; Tapper, Johanna; Trotman, H

doi:10.1179/1465328111y.0000000042

Cited by 12 publications

(3 citation statements)

References 15 publications

(28 reference statements)

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“…Our study has shown that there is a female preponderance for JMG at any age, which is consistent with the existing literature, particularly a recent epidemiological study from the UK . We also found a high rate of JMG among those of African descent (48% of our cohort), which is similar to the 50% reported by Castro et al .…”

Section: Discussionsupporting

confidence: 93%

Clinical features and evolution of juvenile myasthenia gravis in a French cohort

et al. 2017

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Section: Discussionsupporting

confidence: 93%

Clinical features and evolution of juvenile myasthenia gravis in a French cohort

et al. 2017

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“…Epidemiological studies are vital for health service planning for this frequently overlooked group. Despite research in Jamaica (4,5), Cuba (6) and the Dutch Antilles (7), there remains a paucity of information on MG in the West Indies. There are no previous studies on MG in Trinidad and Tobago (T&T).…”

Section: Introductionmentioning

confidence: 99%

Myasthenia Gravis in South Trinidad

Maharaj¹,

Bahadursingh²,

Ramcharan³

2013

West Indian Med J

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“…Previous studies from China reported an AChR-Abs positivity rate between 40% and 78% ( 6 , 13 ), while this rate was relatively higher in other countries ( 8 , 14 ). In our current study, the positivity rate of AChR-Abs was 42.5%.…”

Section: Discussionmentioning

confidence: 80%

Clinical characteristics and outcome predictors of a Chinese childhood-onset myasthenia gravis cohort

Yang

Tang²,

He³

et al. 2022

Front. Pediatr.

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Myasthenia gravis is an organ-specific autoimmune disease. Currently there is no universal guidelines for childhood-onset myasthenia gravis, therefore, treatment strategies are usually based on the guidelines from adult myasthenia gravis patients. In order to contribute in the process of the development of the universal childhood-onset myasthenia gravis guideline, we have summarized the clinical characteristics, treatment strategies, outcome and the related predictors of childhood-onset myasthenia gravis. We recruited 343 childhood-onset myasthenia gravis cases who were followed up at the Department of Pediatrics, Xiangya Hospital from June, 2010 to December, 2019. The data about clinical characteristics, treatments and outcome were collected and analyzed. Among of the 343 cases, 164 cases were followed up for longer than 2 years, of whom 142 still remained with ocular myasthenia gravis at the endpoint. About the treatments, 27 cases (27/164) accepted pyridostigmine only while the rest accepted glucocorticoid and/or other immunosuppressants. At the endpoint, the proportion of optimal outcome was 66.2% in the group remaining with ocular myasthenia gravis and 31.8% in the generalized myasthenia gravis group. Multivariate logistic regression analysis revealed that generalized myasthenia gravis type and positive status of antibodies against acetylcholine receptors were the independent risk factors for poor outcome. In conclusion, our childhood-onset myasthenia gravis patients present mainly as ocular myasthenia gravis, adequate immunotherapy improve the long-term outcome, and generalized myasthenia gravis phenotype as well as positive status of antibodies against acetylcholine receptors relate to poor outcome.

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Myasthenia gravis in Jamaican children: a 12-year institutional review

Abstract: Myasthenia gravis in Jamaican children is similar to that in other populations. It is more common in female children. Most children present with ocular manifestations and remission occurs infrequently.

Cited by 12 publications

References 15 publications

Clinical features and evolution of juvenile myasthenia gravis in a French cohort

Clinical features and evolution of juvenile myasthenia gravis in a French cohort

Myasthenia Gravis in South Trinidad

Clinical characteristics and outcome predictors of a Chinese childhood-onset myasthenia gravis cohort

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