Maxillary sinus floor augmentation on humans: Packing simulations and 8months histomorphometric comparative study of anorganic bone matrix and β-tricalcium phosphate particles as grafting materials

Abstract

The present study compares the behaviour of an anorganic bone matrix material and a synthetic β-Tricalcium phosphate employed as grafting materials in a sinus floor augmentation two step protocol in humans. In order to estimate the initial occupation level for the two materials, an ‘in vitro’ simulation has been performed to analyse macroporosity created due to particle packing in terms of porosity and interparticle distances. Grafting in the sinus floor augmentation was performed by filling the defects only with pure grafting materials without autogenous bone addition. The new-bone generated is 100% based on the osteoconductive properties of the grafted materials in contact with physiological fluids. The implants were placed 8 months after the grafting procedure. All the implanted positions were biopsied and embedded in methacrylate resin. Histomorphometric analyses were done over thin film undecalcified sections. Packing simulations allow establishing a comparison of the resorbed volumes related to the initial occupancy of the grafting materials inside the defect. The nature of this interconnected pore network is very alike for either material so new-bone generated was similar (~35 vol.%).

Bone Forming Potential of An-Organic Bovine Bone Graft: A Cone Beam CT study

“…Our report of anorganic bovine bone graft as a bone forming material is consistent with numerous human histological studies as well. The new-bone generated is 100% based on the osteoconductive properties of the grafted materials, as reported by [23] who have conducted a comparative study using an-organic bone matrix material and a synthetic β-Tricalcium phosphate.…”

Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs

“…β-TCP, which belongs to the group of bioactive bioceramics of completely synthetic origin, is well known as a biodegradable material with good osteoconductive capacity and clinical efficacy [17][18][19][20] . Recently, we demonstrated that tunnel structured β-TCP induced an increase in cells and blood vessels derived from the residual bone when compared with β-TCP composed of macropores with small connecting area, which enhanced periodontal regeneration in class III furcation defects 21) .…”

Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in class III furcation defects in dogs

“…Therefore, we hypothesized that vascularization would enable delivery of cells and supply of nutrients and oxygen to the cells during the initial healing stage without the the small connecting area between macropores. Beta-tricalcium phosphate (β-TCP) belongs to the group of bioactive bioceramics of completely synthetic origin and has been used in periodontology as a bone graft substitute since the 1980s 1,[20][21][22][23] . At present, there are various types of β-TCP composed of macropores with small connecting area [24][25][26] .…”