Maxillary and Mandibular Non-Hodgkin Lymphoma with Concurrent Periapical Endodontic Disease: Diagnosis and Management

Dolan, Jennifer L.; DeGraft-Johnson, Anna; McDonald, Neville J.; Ward, Brent B.; Phillips, Tycel; Munz, Stephanie M.

doi:10.1016/j.joen.2017.04.001

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…Of the cases shown in Table 2, 29 [9, 46–72] were reported as single case reports. A case series of three B-cell NHLs [44] and a double case report [73] are included in the SR in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

MacDonald

Lim

2017

Oral Radiol

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ObjectivesExtranodal lymphomas affecting the head and neck infrequently arise within the jaw bones. Although clinical examination and conventional radiography may initially suffice for such lesions arising within the mandible, those arising within the maxillary alveolus generally require cross-sectional imaging because of the complex anatomy of this region. This study was performed to determine the prevalence, demographic characteristics, and clinical presentations of these lesions and the imaging modalities used for their diagnosis.Study designA systematic review (SR) on case series and another SR on case reports were performed to investigate the demographic, clinical, and radiological features of extranodal lymphomas arising within the maxillary alveolus.ResultsMost case series were derived from just four nations, whereas the case reports were derived from a wider range of ethnicities. The more detailed case reports significantly reported at least one imaging modality. Most patients were aware of their lesions for nearly 2 months before presentation. The most frequent symptom was swelling. Most case reports included a provisional diagnosis, the most frequent of which was dental infection followed by squamous cell carcinoma.DiscussionExtranodal lymphomas arising within the maxillary alveolus were sufficiently frequent in four communities to be reported in two or more case series, and the occasional single case report indicated that such lesions are more widespread globally. Although the SR on case series revealed differences in the relative period prevalence and maxillary/mandibular ratio, the SR on case reports revealed details of the clinical presentation and imaging modalities used.

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Section: Resultsmentioning

confidence: 99%

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

MacDonald

Lim

2017

Oral Radiol

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“…The origin of NHL of the jaw is unclear, although several authors suggested a possible role of chronic inflammation, supported by the fact that these malignomas are often first diagnosed as periapical inflammation or osteomyelitis [9,[32][33][34]. In the present case, a question also arose as to whether the trepanation of the 24 and 25 teeth was based on a reliable diagnosis.…”

Section: Discussionmentioning

confidence: 76%

“…Since very little data are available on the pathogenesis and clinical behaviour of HGBL, NOS lymphomas are referred to as "grey-zone" lymphomas, and there is no consensus on their standard therapy [23]. There are few reports of NHL in the maxillary sinus [9,31,32], but, to our knowledge, the present case represents the first description of HGBL, NOS located in the maxillary sinus.…”

Section: Discussionmentioning

confidence: 85%

High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature

et al. 2021

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High-grade B-cell lymphoma not otherwise specified is listed as a new group in the WHO 2017 statement as a subtype of aggressive, mature B-cell lymphomas with a poor prognosis. To our knowledge, no description of this genetic type of maxillary lymphoma has appeared in the literature until now; thus, our case provides valuable data on its symptoms, clinical behavior, response to treatment and survival rate. The present report describes the early diagnosis and treatment of an extremely rare histological subtype of B-cell lymphoma, a case of high-grade B-cell lymphoma not otherwise specified, localized in the maxillary sinus and mimicking signs and symptoms of periapical inflammation. After chemotherapy, the presented patient showed complete remission without relapse and systemic spread. As far as we know, this is the first reported case of this rare type of lymphoma associated with the maxillary sinus. Considering that high-grade B-cell lymphomas are aggressive tumors with rapid growth and poor prognosis, which are often misdiagnosed in the early stages as inflammatory disease, it is relevant to highlight the importance of a detailed evaluation of clinical signs and radiological findings during diagnosis, especially if they contradict each other.

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“…DLBCL-NOS in the oral and maxillofacial regions may have very diverse manifestations including but not limited to local bone invasion, painless soft tissue swelling or ulceration, and toothache similar to that of periapical endodontic disease or pulpitis. Several articles have described delayed definitive diagnosis and relatively poor prognosis due to the atypical manifestation of maxillofacial lymphoma as toothache [ 4 , 6 , 12 ]. Fatahzadeh [ 4 ] reported a case of diffuse large B-cell lymphoma of mandible masquerading as toothache, in which etiology was not identified until the clinicopathologic examination was performed.…”

Section: Discussionmentioning

confidence: 99%

Primary Extra Nodal Diffuse Large B-Cell Lymphoma of the Maxillary Sinus with Symptoms of Acute Pulpitis

Cui

Zhang

2022

Case Reports in Dentistry

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Diffuse large B-cell lymphoma not otherwise specified (DLBCL-NOS) is a subtype of large B-cell non-Hodgkin lymphoma with various clinical and pathological manifestations. DLBCL-NOS which primarily arises from maxillary sinus is rare and hard to diagnose due to unique anatomy. Here, we present a case of DLBCL-NOS that developed in the left maxillary sinus of a 72-year-old male, who presented with severe toothache that resembled acute pulpitis. The lesion was diagnosed and treated based on radiographs, histological, immunohistological examinations, and PET-CT analysis. Despite its rare incidence, DLBCL-NOS should still be included in differential diagnoses to rule out malignancy in cases of endodontic disease.

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Maxillary and Mandibular Non-Hodgkin Lymphoma with Concurrent Periapical Endodontic Disease: Diagnosis and Management

Cited by 12 publications

References 23 publications

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

Extranodal lymphoma arising within the maxillary alveolus: a systematic review

High-Grade B-Cell Lymphoma Not Otherwise Specified (HGBL, NOS) in the Maxillary Sinus Mimicking Periapical Inflammation: Case Report and Review of the Literature

Primary Extra Nodal Diffuse Large B-Cell Lymphoma of the Maxillary Sinus with Symptoms of Acute Pulpitis

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