The number of oral cancers associated with Human Papillomavirus (HPV) infection is increasing worldwide. The purpose of this retrospective clinical trial is to investigate the relationship between genital and oral HPV infection and to observe the possibilities of polymerase chain reaction (PCR) technique and the limitations for oral HPV infection. The results of genital and oral HPV screening of 34 female patients and their partner, and 14 single female patients were processed in a private practice in Budapest between 2012 and 2015. After brush-biopsy sampling, HPV DNA identification and typing were performed using PCR technique. All in all 164 samples were typed. HPV DNA was detected in 76 cases (48.20%). HPV was detected in 55 cases from the genital samples (67%), and in 21 cases from the oral samples (25.6%). Genital HPV infection was statistically significantly higher in women (79.2% vs 22,9%, p[0.001). Gender comparison of genital HPV infection showed a statistically significant difference (79.2% for women, 50% for men, p = 0.006). In case of genital HPV infection, the oral HPV infection of the same person is more frequent. In this study, the above mentioned difference is significant for women and not significant for men. HPV16 is the HPV genotype which was identified in the highest ratio(47.2%). PCR technique is capable of the detection of oral HPV infection, but follow-up studies with higher case number , and questionnaire studies are needed to understand HPV transmission more accurately.

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ObjectiveOne‐third of the Hungarian population suffers from xerostomia. Since there is no evidence of the actual prevalence of Sjögren's syndrome (SS) in Hungary, this study aimed to evaluate the same.Materials and MethodsData were collected from the Faculty of Dentistry, Semmelweis University from 2008 to 2015. A diagnosis of SS was established based on the American College of Rheumatology and European League Against Rheumatism criteria.ResultsOf the 1076 patients examined with sicca symptoms, 188 patients had confirmed SS. Primary SS (pSS) was diagnosed in 135 patients and secondary SS (sSS) was confirmed in 53 patients. According to the available statistical records of the public health service of Hungary, there were an average of 16 (0.0014%, 5–26) newly diagnosed SS cases in the entire population and 141 SS patient‐practitioner consultations (49–232) per 100,000 inhabitants in the country over the past 10 years (based on the past 10 years: 2011–2020).ConclusionResults revealed that approximately 1/5th–1/6th of patients with sicca symptoms have SS, among whom 72% and 285 have pSS and sSS, respectively. Global Hungarian records simultaneously revealed that the number of both new diagnoses and doctor‐SS patient encounters has significantly decreased (by 50%) yearly over the last decade.

The aim of the study was to assess the preventive and therapeutic efficacy of a sustained-release varnish (SRV) Cervitec Plus� compared with Corsodyl� mouthwash against Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata on acrylate surfaces. Nystatin as the positive control, and sterile saline solution as the negative control, were used. To examine the preventive efficacy of the agents, Candida biofilms were developed in Sabouraud liquid medium, and mature biofilms were treated with the antifungal. To investigate the preventive efficacy, the agents were applied to the wells of the plates and the biofilms were grown in the treated wells. To determine the metabolic activity of biofilms, the XTT-assay was used. In the case of C. albicans and C. parapsilosis, the most effective therapeutic product was Corsodyl� followed by Cervitec Plus� and Nystatin. The differences were statistically significant when Corsodyl� was compared to Nystatin ( p � 0.05). In relation to C. tropicalis and C. glabrata, Corsodyl� showed the greatest therapeutic efficacy followed by Nystatin and Cervitec Plus�. For both species, the results of Corsodyl� and Cervitec Plus� showed statistically significant difference ( p � 0.05). The most effective preventive product for each examined Candida species was Nystatin, followed by Cervitec Plus� and Corsodyl�. Significant differences were between Nystatin and Corsodyl� (p � 0.05). The preventive and therapeutic efficacy of Cervitec Plus� and Corsodyl�, against the examined Candida species, was detected. Because of the disadvantageous side-effects of Nystatin, Cervitec Plus� can be considered as an alternative preventive agent against Candida species.

Billions of microorganisms can be found in the oral cavity, from which bacteria are the most frequent. More than 600 bacterial species can be isolated. Most of them are harmless, moreover, some species prove themselves to be specifically useful. However, in the case of a weakened immune status or inappropriate oral hygiene, they may cause many types of soft and hard tissue disorders. Caries and periodontal diseases are the most common bacterial diseases of the oral cavity. In both cases, the dental biofilm gives rise to the disorder, which is caused by the insufficient oral hygiene. Dental caries are mainly caused by cariogenic streptococci and lactobacilli. In the case of serious periodontal diseases, anaerob parodonto-pathogen microorganisms play the major role. Untreated caries may result in the necrosis of the pulp, which can cause an inflammation expanding towards the parodontium. This can be characterized as a focal infection, like the untreated periodontal pockets. Dental foci may have lots of systemic consequences such as cardiovascular diseases, diabetes, pneumonia, arthritis, preterm birth and alopecia areata. When these diseases occur, dental foci should always be considered. The professional plaque control and chlorhexidine rinsing before the proposed surgeries have an outstanding role in the prevention of ventilator-associated pneumonia. Oral cancer is multicausal; more and more researchers are analyzing the role of certain bacteria in the carcinogenesis of oral cancer. In addition to the mentioned clinical aspects, we are planning to describe the relatively rare, but diverse and diagnostically challenging bacterial soft tissue disorders in another publication. Orv Hetil. 2019; 160(19): 739–746.

A non-Hodgkin lymphomák a fej-nyaki rosszindulatú daganatok ritka formái. Gyakran mellékleletként kerülnek diagnosztizálásra,vagy előrehaladott állapotban, a klinikai tünetek megjelenésével. A stomato-onkológiai szűrés során akkor lehetségesdiagnosztizálni, ha valamilyen mértékben a szájüreg felé kezd terjedni. Jelen közleményben egy sinus maxillaristérintő diffúz nagy B-sejtes lymphomás páciens diagnosztikai lépései, onkológiai ellátása és teljes fogászati rehabilitációjakerül bemutatásra, melyet nagymértékben meghatározott a páciens alapbetegsége. Végeredményben a korai diagnózisnak,az időben megkezdett sikeres onkológiai ellátásnak köszönhetően a daganat teljes remissziót mutatott, tizennyolchónap elteltével relapszus nem jelentkezett. A páciens általános állapota jó, az elkészült fogászati restaurátumokkal,fogművekkel elégedett, rendszeres kontrollra visszajár.

No abstract

High-grade B-cell lymphoma not otherwise specified is listed as a new group in the WHO 2017 statement as a subtype of aggressive, mature B-cell lymphomas with a poor prognosis. To our knowledge, no description of this genetic type of maxillary lymphoma has appeared in the literature until now; thus, our case provides valuable data on its symptoms, clinical behavior, response to treatment and survival rate. The present report describes the early diagnosis and treatment of an extremely rare histological subtype of B-cell lymphoma, a case of high-grade B-cell lymphoma not otherwise specified, localized in the maxillary sinus and mimicking signs and symptoms of periapical inflammation. After chemotherapy, the presented patient showed complete remission without relapse and systemic spread. As far as we know, this is the first reported case of this rare type of lymphoma associated with the maxillary sinus. Considering that high-grade B-cell lymphomas are aggressive tumors with rapid growth and poor prognosis, which are often misdiagnosed in the early stages as inflammatory disease, it is relevant to highlight the importance of a detailed evaluation of clinical signs and radiological findings during diagnosis, especially if they contradict each other.