Matrix metalloproteinases’s association of polymorphisms of MMP3 and MMP9 with development of genital endometriosis

Yarmolinskaya, Maria I.; Molotkov, A. S.; Bezhenar, V. F.; Shved, Natallia; Ivaschenko, T. E.; Baranov, V. S.

doi:10.1134/s1022795414010128

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Numerous factors are involved in endometriosis-associated angiogenesis including matrix metalloproteinases (MMPs), TNF- ɑ , cyclo-oxygenase (COX), and hypoxia-inducible factor 1 α (HIF-1). MMPs degrade the extracellular matrix and are key components of endometrial adhesion and angiogenesis [ 26 , 27 ]. TNF- ɑ promotes angiogenesis during the progression of endometriosis.…”

Section: Resultsmentioning

confidence: 99%

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Zheng

Cao²,

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogenic effects have been investigated, and the molecular basis underlying their therapeutic effects in endometriosis has been explored. This review aims to describe natural products and compounds that suppress angiogenesis associated with endometriosis and to assess their diverse molecular mechanisms of action. Furthermore, this review provides a source of information relating to alternative and complementary therapeutic products that mediate anti-angiogenesis. An extensive review of the literature and electronic databases, such as the China National Knowledge Infrastructure, PubMed, and Embase, was conducted using the keywords ‘endometriosis,' ‘traditional Chinese medicine,' ‘Chinese herbal medicine,' ‘natural compounds,' and ‘anti-angiogenic' therapy. Anti-angiogenic therapy is an emerging strategy for the treatment of endometriosis. Natural anti-angiogenic products and Chinese medicines provide several beneficial clinical effects, including pain relief. In this review, we summarize clinical trials and experimental studies of endometriosis using natural products and Chinese medicines. In particular, we focus on anti-angiogenic products and alternative and complementary medicines for the treatment of endometriosis and additionally examine their therapeutic efficacy and mechanisms of action. Anti-angiogenic natural products and/or compounds provide a new approach for the treatment of endometriosis. Future work will require randomized trials with larger numbers of subjects, as well as long-term follow-up to confirm the findings described here.

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Section: Resultsmentioning

confidence: 99%

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Zheng

Cao²,

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…According to the inclusion criteria, 46 full-text studies were assessed for eligibility. Subsequent to reading the full text, 15 studies were excluded and 19 that were not relevant to either MMP-2 or MMP-9 were also excluded, 5 were excluded for duplicate data and 1 was excluded for focusing on other gene polymorphisms of MMP-9 [rs17576 (R279Q) and rs2250889 (P574R)] (29). Finally, 6 studies (12,13,23,(30)(31) were included, of which 3 were conducted on MMP-9 genetic polymorphisms, 2 were conducted on MMP-2 genetic polymorphisms and 1 was conducted on MMP-9 and MMP-2 (Fig.…”

Section: Characteristics Of Studies Included In the Meta-analysismentioning

confidence: 99%

Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis

et al. 2015

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Matrix metalloproteinase-2 ()-735C/T and -1562C/T polymorphisms have been indicated in the predisposition to endometriosis. However, due to the small sample sizes of previous studies, the results remain inconclusive. The present meta-analysis was conducted to detect the association between the two genetic polymorphisms and the risk of endometriosis by pooling all the available data. Electronic databases, including PubMed, Embase, Web of Science and CNKI, were searched comprehensively for studies examining a link between and polymorphisms and endometriosis. The strength of the association was assessed based on the pooled odds ratio with a 95% confidence interval, which was calculated using either the fixed- or random-effect model. Following the inclusion criteria, 6 case-control studies were included. The total number of participants was 2,486 (558 cases and 797 controls concerning the-1562C/T polymorphism, and 525 cases and 606 controls concerning the -735C/T polymorphism). No significant association was identified between the-735C/T or -1562C/T polymorphism and endometriosis. In further stratified analysis, no significant association was identified between the-1562C/T polymorphism and endometriosis. The present meta-analysis revealed no association between the -735C/T and-1562C/T polymorphisms and the risk of developing endometriosis. Considering the limitations of the meta-analysis, well-designed studies with larger sample sizes are required.

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“…Анализ полиморфизмов генов ангиотензин-1 пре-вращающего фермента (angiotensin I converting enzyme -ACE) и MMP-2 показал отсутствие связи с эндометриозом, в то время как полиморфизмы генов MMP-1, ММР-3 и ММР-9 связаны с высоким ри-ском развития этого заболевания [43]. Аналогичные результаты показаны в другом исследовании [44]: комбинация аллельных полиморфизмов MMP-3 (rs3025058) x MMP-7 (rs11568818) x MMP-9 (rs17576) связана с повышенным риском развития наружного генитального эндометриоза.…”

Section: инвазияunclassified

‘Omic’ high-throughput technologies in research on pathogenesis of endometriosis: a Review

Tikhonchuk¹,

Nepsha²,

Adamyan³

et al. 2016

Probl. reprod.

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Matrix metalloproteinases’s association of polymorphisms of MMP3 and MMP9 with development of genital endometriosis

Cited by 9 publications

References 20 publications

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis

‘Omic’ high-throughput technologies in research on pathogenesis of endometriosis: a Review

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