Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy

Yadav, Lalita; Puri, N. D.; Rastogi, Vishal; Satpute, Pranali Shirish; Ahmad, Rauf; Kaur, Geetpriya

doi:10.7314/apjcp.2014.15.3.1085

Cited by 179 publications

(134 citation statements)

References 66 publications

(86 reference statements)

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“…Matrix metalloproteinase (MMPs) have zinc (Zn) in their active site and participate in the metastases of cancer cells (Yadav et al, 2014). Oxidative stress in breast tumor cells, by stimulating metalloproteinase and inhibition antiproteases, provides an appropriate niche for cell migration and metastasis.…”

Section: Oxidative Stress and Breast Cancermentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

143

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Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain. It plays a critical role in the initiation and progression of various types of cancers. ROS affects different signaling pathways, including growth factors and mitogenic pathways, and controls many cellular processes, including cell proliferation, and thus stimulates the uncontrolled growth of cells which encourages the development of tumors and begins the process of carcinogenesis. Increased oxidative stress caused by reactive species can reduce the body's antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are main factors in the development of cancer. Bimolecular reactions cause free radicals in which create such compounds as malondialdehyde (MDA) and hydroxyguanosine. These substances can be used as indicators of cancer. In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.

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Section: Oxidative Stress and Breast Cancermentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

143

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“…The key proteases involved in degrading the components of the ECM are matrix metalloproteinases (MMPs) (Yadav et al, 2014). Therefore, inhibition of ECM degradation was used as the target for anti cancer metastasis.…”

Section: Introductionmentioning

confidence: 99%

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Pintha

Yodkeeree²,

Pitchakarn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Tumor invasion and metastasis are a complex and multi-step continuous process involving various molecules, especially matrix metalloproteinases (MMPs) (Yadav et al, 2014). During tumor invasion and metastasis, MMPs degrade the basement membrane and extracellular matrix (ECM) so that tumor cells can invade and metastasize into adjacent or distant organs.…”

Section: Introductionmentioning

confidence: 99%

Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

Wang¹,

Ma²,

Jin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.Keywords: Extra-gastrointestinal stromal tumor (EGIST) -MMP-2 -MMP-9 -tumor invasion and metastasis -biomarker

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Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy

Cited by 179 publications

References 66 publications

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

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