Matrix metalloproteinases: A double edge sword

Bali, Praveen Kumar; Kalaivanan, Dhanraj; Divater, Vijayalaksmi; Logarani,

doi:10.4103/2348-1471.171916

Cited by 3 publications

(2 citation statements)

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“…MMPs are a family of enzymes and 23 types have been described in humans. They are dependent on calcium and zinc for activity and are characterized by having four domains in their composition: the peptide-signal domain, the propeptide domain (composed of cysteine with its sulfhydryl groups), a catalytic domain (with zinc at the site of catalytic activity together with histidine and calcium residues), and a hemopexin-type domain that serves to bind to the substrate and which is the site where specific tissue inhibitors bind [30] (Figure 3).…”

Section: Methodsmentioning

confidence: 99%

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Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer

Betancourt

Baldión

Castellanos

2019

International Journal of Biomaterials

107

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Several studies have shown that the dentin-resin interface is unstable due to poor infiltration of resin monomers into the demineralized dentin matrix. This phenomenon is related to the incomplete infiltration of the adhesive system into the network of exposed collagen fibrils, mainly due to the difficulty of displacement and subsequent replacement of trapped water between interfibrillar spaces, avoiding adequate hybridization within the network of collagen fibrils. Thus, unprotected fibrils are exposed to undergo denaturation and are susceptible to cyclic fatigue rupture after being subjected to repetitive loads during function. The aqueous inclusions within the hybrid layer serve as a functional medium for the hydrolysis of the resin matrix, giving rise to the activity of esterases and collagenolytic enzymes, such as matrix metalloproteinases, which play a fundamental role in the degradation process of the hybrid layer. Achieving better interdiffusion of the adhesive system in the network of collagen fibrils and the substrate stability in the hybrid layer through different strategies are key events for the interfacial microstructure to adequately function. Hence, it is important to review the factors related to the mechanisms of degradation and stabilization of the hybrid layer to support the implementation of new materials and techniques in the future. The enzymatic degradation of collagen matrix, together with resin leaching, has led to seeking strategies that inhibit the endogenous proteases, cross-linking the denudated collagen fibrils and improving the adhesive penetration removing water from the interface. Some of dentin treatments have yielded promising results and require more research to be validated. A longer durability of adhesive restorations could resolve a variety of clinical problems, such as microleakage, recurrent caries, postoperative sensitivity, and restoration integrity.

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Section: Methodsmentioning

confidence: 99%

“…MMPs can be activated in vivo by proteases and other MMPs, in vitro by chemical agents such as modifiers of the sulfhydryl groups, chaotropic agents, and reactive oxygen, as well as physical agents such as low pH and heat [30, 34, 39].…”

Section: Methodsmentioning

confidence: 99%

Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer

Betancourt

Baldión

Castellanos

2019

International Journal of Biomaterials

107

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Effect of myricetin on odontoblast-like cells and its potential to preserve resin–dentin Bonds

Baldión

Cortes

Castellanos

et al. 2021

Journal of the Mechanical Behavior of Biomedical Materials

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The Photomodulation Activity of Metformin Against Oral Microbiome

2019

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Periodontitis is one of the most common inflammatory diseases of the periodontium, which results in the inflammatory destruction of supporting structures around teeth and is closely associated with the development of systemic disease. Due to a wide variety of antibiotic resistance periodontopathic bacteria, photodynamic therapy (PDT) is a non-invasive adjunctive therapeutic modality that is capable of destroying the whole range of microbes. Metformin (Metf) is an antidiabetic drug, and recent studies suggest that cancer patients who receive Metf and are exposed to radiotherapy and chemotherapy show better outcomes. Our surveys in this review introduce Metf as a potent stimulus in increasing the efficacy of PDT in the induction of destruction in microbial cells.

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Matrix metalloproteinases: A double edge sword

Cited by 3 publications

References 0 publications

Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer

Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer

Effect of myricetin on odontoblast-like cells and its potential to preserve resin–dentin Bonds

The Photomodulation Activity of Metformin Against Oral Microbiome

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