Effect of myricetin on odontoblast-like cells and its potential to preserve resin–dentin Bonds

Baldión, Paula Alejandra; Cortes, Cristhian C.; Castellanos, Jaime E.; Betancourt, Diego Enrique

doi:10.1016/j.jmbbm.2021.104392

Cited by 8 publications

(8 citation statements)

References 59 publications

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“…A total of 50 articles were included in the qualitative analysis. Of these, 5 articles were not considered for the meta-analysis because two of them did not express the BS data as means and SDs [ 76 , 77 ], and in 3 articles the number of specimens used could not be retrieved [ 78 , 79 , 80 ], totalling 45 articles considered for the quantitative analysis [ 17 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. A flowchart designating the study selection process according to the PRISMA statement is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

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Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

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This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (p £ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (p ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system.

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Section: Resultsmentioning

confidence: 99%

“… Forest plot of the immediate ( A ) and long-term ( B ) bond strength comparison between the proanthocyanidins crosslinking agent and the control according to the adhesive used [ 17 , 81 , 83 , 89 , 92 , 105 , 108 , 110 , 112 , 123 ]. …”

Section: Figurementioning

confidence: 99%

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

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“…A total of 216 studies were not included; many studies were excluded based on the eligibility criteria (182); data not available ( Mazzoni et al, 2013b ); without long-term bond strength ( Hass et al, 2016a ), and conducted on bovine teeth ( Comba et al, 2020 ). Finally, seven-eight studies were included in the review ( Cova et al, 2011 ; Castellan et al, 2013 ; Chiang et al, 2013 ; Andre et al, 2015 ; Carvalho et al, 2016 ; Abunawareg et al, 2017 ; Bacelar-Sa et al, 2017 ; Albuquerque et al, 2019 ; Costa et al, 2019 ; Czech et al, 2019 ; Baena et al, 2020 ; Beck and Ilie, 2020 ; Comba et al, 2020 ; Abdelshafi et al, 2021 ; Baldion et al, 2021 ; Chen et al, 2021 ; Dacoreggio et al, 2021 ; Abd El-Aal et al, 2022 ; Beck and Ilie, 2022 ) and meta-analysis for which the primary data (mean bond strength, standard deviation, and the number of test samples) could be retrieved.…”

Section: Resultsmentioning

confidence: 99%

Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis

Chen

Sun

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: This study aimed to evaluate the role of collagen cross-linkers in the bonding performance of the resin-dentin interface through a systematic review and a network meta-analysis.Sources: The literature search was conducted in several databases like PubMed, EMBASE, Cochrane, Scopus and Web of Science from their inception till 30 April 2022.Study selection: The inclusion criteria consisted of in vitro studies evaluating the micro-tensile and micro-shear bond strengths of different cross-linkers acting on dentin. Bayesian network meta-analysis was conducted using RStudio.Data: Out of the 294 studies evaluated in the full-text analysis, 40 were included in the systematic review and meta-analysis. Most studies have used cross-linkers as primer (65.1%), followed by incorporating them into in adhesives and acid etching agents. The application methods of the adhesive system were classified as “etch-and-rinse (ER) adhesives” (77%) and “self-etching (SE) adhesives”. Moreover, there were six types of cross-linkers in this presented review, of which the most numerous were polyphenols.Conclusion: Different application methods of cross-linkers, the long-term results showed that were only effective when used for longer durations, the immediate results were not statistically different. According to immediate and long-term results, etch-and-rinse (ER) adhesives showed a greater bonding performance than the control groups (p ≤ 0.05), whereas self-etching (SE) adhesives showed similar bond strength values (p ≥ 0.05). The result of network meta-analysis (NMA) showed that Dope like compound showed higher long-term bonding performance than other cross-linkers.Clinical significance: Long-term clinical studies may be needed to determine the effect of the cross-linkers on the bonding properties.

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“…In this stage, 55 mg/mL PA/ethanol, 0.2 mg/mL myricetin/ethanol, 10 mg/mL resveratrol/ethanol, and 10 mg/mL kaempferol/ethanol primers were prepared and stored at 4°C before use. 16 , 17 , 25 , 27 All the chemical reagents were purchased from Macklin, Shanghai, China. Dentin slices were immersed in 1 M/L hydrochloric acid (HCl) for 12 h for complete demineralization (examined using an intraoral dental X-ray device [Focus 50540-IMG, KAVO, California, USA]), 28 rinsed completely with double distilled water, and blotted dry.…”

Section: Methodsmentioning

confidence: 99%

“…Natural polyphenols, such as proanthocyanidins (PA), 13 quercetin, 14 catechins, 15 myricetin, 16 resveratrol, 17 and kaempferol 18 contain multiple phenolic -OH groups, which can form hydrogen bonds with collagen amide carbonyl groups to modify the collagen and inhibit MMPs. These -OH groups at the free end can also chelate with metal cations (e g, Ca 2+ , Mg 2+ , and Au 2+ ), thereby potentially accelerating ACP nanoparticle deposition and HA formation.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix

Wang¹,

Han²,

You³

et al. 2023

IJN

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Objective To investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on the modification of dentin collagen and the inhibition of matrix metalloproteinase (MMP) activity, and to evaluate their contributions to the biomimetic remineralization and resin-dentin bonding performance. Methods Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and in situ zymography were applied to verify the collagen modification and MMP activity inhibition induced by these four polyphenols. Scanning electron microscopy/energy dispersive spectrometer (SEM/EDS) analysis, X-ray diffraction (XRD), ATR-FTIR, Vickers hardness numbers (VHN), and micro-computed tomography (micro-CT) were performed to characterize the remineralized dentin. Microtensile bond strength (μTBS) and nanoleakage were investigated to evaluate the effects of the four polyphenols on resin-dentin bonding durability. Results ATR-FTIR and in situ zymography confirmed that these four polyphenols could modify dentin collagen and inhibit MMP activity, respectively. Chemoanalytic characterization exhibited the efficacies of the four polyphenols in promoting dentin biomimetic remineralization. The surface hardness of PA-pretreated dentin was the greatest. Micro-CT results demonstrated that the PAs group possessed the highest amount of dentin surface minerals and the lowest amount of deep-layer minerals. The surface and deep-layer mineral contents of the Myr group were higher than Res and Kae groups. Treatment with these four polyphenols significantly increased the initial μTBS compared with the control group without primer conditioning. μTBS decreased significantly during aging, and the decrease was more severe in the PAs and Kae groups than in the Myr and Res groups. With or without aging, the polyphenol groups exhibited relatively less fluorescence. However, the Myr and Res groups showed less serious nanoleakage after aging. Conclusion PA, myricetin, resveratrol, and kaempferol can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability. Compared with PA and kaempferol, myricetin and resveratrol are more effective in improving resin-dentin bonding.

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Effect of myricetin on odontoblast-like cells and its potential to preserve resin–dentin Bonds

Cited by 8 publications

References 59 publications

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis

Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix

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