The Photomodulation Activity of Metformin Against Oral Microbiome

Afrasiabi, Shima; Pourhajibagher, Maryam; Bahador, Abbas

doi:10.15171/jlms.2019.39

Cited by 9 publications

(6 citation statements)

References 142 publications

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“…Evidence of vasodilation and formation of collagen has also been observed. [ 54 55 56 57 58 ] The positive effects of PDT have also been documented in in vitro and study involving experimental animal models. [ 59 60 ] Although PDT shows promising results, given the problems that refractory cases show, it may not be suitable for all cases.…”

Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Objective: The purpose of the study is to evaluate the various lasers in dentistry and to investigate if it can be used for treatment of refractory periodontitis. Methods: The study followed partially the PRISMA guidelines as it is a narrative review. A number of articles were selected from a period of 1980 to 2020 from databases, PubMed, PubMed central, Cochrane and Scopus. Articles related to the effects of lasers on periodontitis both refractory and aggressive were investigated. Results: After reviewing the literature, 70 articles were found, related to application of lasers in periodontal diseases. Out of the 70, 11 articles pertained to the effect of laser for the treatment of Refractory and inflammatory periodontitis. 5 articles related to experimental animal models, one pertaining to in-vitro and six studies related to in-vivo in human cohorts. Discussion: It was found that lasers if used in controlled parameters by incorporating laser assisted treatment such as Photodynamic therapy and low level laser therapy can be of use as an adjunct therapy for treatment of refractory periodontitis. The use of different wavelengths in the initial and maintenance phase of periodontal disease plays a positive role. The presence of in-vitro and animal model studies is one of the limitation to this study. The available studies have shown marked reduction in inflammation and better clinical and microbiological parameters. The drawback of this study is the limited literature involving laser management for refractory periodontitis in human cohorts. Conclusion: Different wavelengths of laser and choice of laser assisted periodontal treatment plays an important role in the overall progress and prognosis of periodontal disease activity.

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Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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“…The products produced in these reactions can cause significant damage to microorganisms and irreversibly alter their metabolic activity, resulting in the death of target cells [16]. vates photosensitizers in the presence of oxygen to produce free radicals and reactive oxygen species (ROS) that are capable of causing cell death [9,10]. Compared with other conventional antimicrobials, APDT has several strengths, including that APDT is a multitarget process, in which the spread of microbial resistance will be very rare.…”

Section: Mechanism Of Action Of Apdtmentioning

confidence: 99%

“…APDT is a minimally invasive antimicrobial approach that has been proposed as adjunctive therapy for the treatment of local infections that are resistant to antibiotics [8]. APDT is a procedure that activates photosensitizers in the presence of oxygen to produce free radicals and reactive oxygen species (ROS) that are capable of causing cell death [9,10]. Compared with other conventional antimicrobials, APDT has several strengths, including that APDT is a multitarget process, in which the spread of microbial resistance will be very rare.…”

Section: Introductionmentioning

confidence: 99%

The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

et al. 2022

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Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, chlorella, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.

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“…Metformin is associated with reduced serum levels of C reactive protein (CRP) and monocyte release of TNF-α, IL-1β, IL-6, MCP-1, and IL-8 in pre-diabetic patients[ 171 ]. Another study reported elevated bactericidal and anti-inflammatory outcomes upon combining metformin with photodynamic therapy for the treatment of chronic resistant periodontitis[ 172 ].…”

Section: Biguanide (Metformin)mentioning

confidence: 99%

Anti-diabetics and antimicrobials: Harmony of mutual interplay

Hegazy¹,

Rajab²,

Lila³

et al. 2021

WJD

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Diabetes is one of the four major non-communicable diseases, and appointed by the world health organization as the seventh leading cause of death worldwide. The scientists have turned over every rock in the corners of medical sciences in order to come up with better understanding and hence more effective treatments of diabetes. The continuous research on the subject has elucidated the role of immune disorders and inflammation as definitive factors in the trajectory of diabetes, assuring that blood glucose adjustments would result in a relief in the systemic stress leading to minimizing inflammation. On a parallel basis, microbial infections usually take advantage of immunity disorders and propagate creating a pro-inflammatory environment, all of which can be reversed by antimicrobial treatment. Standing at the crossroads between diabetes, immunity and infection, we aim in this review at projecting the interplay between immunity and diabetes, shedding the light on the overlapping playgrounds for the activity of some antimicrobial and anti-diabetic agents. Furthermore, we focused on the anti-diabetic drugs that can confer antimicrobial or anti-virulence activities.

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The Photomodulation Activity of Metformin Against Oral Microbiome

Cited by 9 publications

References 142 publications

Applications of lasers in refractory periodontitis: A narrative review

Applications of lasers in refractory periodontitis: A narrative review

The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

Anti-diabetics and antimicrobials: Harmony of mutual interplay

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