Matrix metalloproteinase-9 (MMP-9) in allergic nasal polyps

Buğdaycı, Güler; Kaymakçı, Mustafa; Bukan, Neslihan

doi:10.1016/j.acthis.2008.07.002

Cited by 10 publications

(11 citation statements)

References 19 publications

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“…In our data, atopy seemed to result to higher MMP‐8, MMP‐9, and MPO concentrations locally in nasal secretions, with the lowest variation in the asthma group. This is consistent with the earlier results in CRSwNP and asthma . Atopic patients have been shown to exhibit faster and stronger neutrophil activation in the nasal cavity .…”

Section: Discussionsupporting

confidence: 93%

“…Studies in asthma have also shown a poor correlation in the MMP‐9 levels between bronchoalveolar lavage (BAL) fluid and serum regardless of the results from multiple separate studies showing that increased level of MMP‐9 in BAL fluid or sputum but also in serum is a constant finding in adult patients and correlates with disease severity . In the only published study comparing serum MMP levels in CRS patients with healthy controls Bugdayci et al found that the plasma MMP‐9 concentrations were significantly higher in allergic CRSwNP patients relative to nonallergic CRSwNP patients and controls, whereas in nonallergic patients they were on the same level with controls. In our study serum MMP‐9 levels were higher in both SPT+ and SPT− CRSwNP compared to SPT+ and SPT− controls, but the differences were not significant, nor did SPT+ CRSwNP differ from SPT− CRSwNP.…”

Section: Discussionmentioning

confidence: 99%

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Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma

Katainen

Kostamo

Virkkula

et al. 2015

Int Forum Allergy Rhinol

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma

Katainen

Kostamo

Virkkula

et al. 2015

Int Forum Allergy Rhinol

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“…Elevated levels of MMP-9 protein [5-8] and MMP-9 mRNA [6,7] were found in the cases of nasal polyposis. Elevated plasma MMP-9 level was also reported recently in patients with allergic nasal polyps [9]. Patients with poor-healing reaction after sinus surgery had more severe edematous and fibrotic changes [10], and higher amounts of MMP-9 in both nasal secretions [11] and connective tissue [12] when compared with good healers.…”

Section: Introductionmentioning

confidence: 79%

Matrix metalloproteinase-9gene polymorphisms in nasal polyposis

et al. 2010

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BackgroundMatrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis.MethodsWe conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing.ResultsAll four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases.ConclusionsWe concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population.

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“…20 Elevated plasma MMP-9 levels were also recently reported in patients with allergic NPs. 21 Patients with poorhealing reaction after sinus surgery had more severe edematous and fibrotic changes 22 and higher quantities of MMP-9 in both nasal secretions 23 and connective tissue 24 when compared with normal healers.…”

mentioning

confidence: 98%