Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma

Katainen, Elina; Kostamo, Katriina; Virkkula, Paula; Sorsa, Timo; Tervahartiala, Taina; Haapaniemi, Aaro; Toskala, Elina

doi:10.1002/alr.21486

Cited by 11 publications

(14 citation statements)

References 49 publications

(83 reference statements)

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“…Neutrophil elastase plays an important role in the development of airway inflammation and hyperresponsiveness, which are key factors in the pathophysiology of asthma [84]. Compared to healthy controls, patients with bronchial asthma have a higher activity of neutrophil elastase [85,86]. In asthmatics, VIGNOLA et al [87] showed that neutrophil elastase activity is negatively correlated with FEV1.…”

Section: Risk Of Asthma In the Mz Populationmentioning

confidence: 99%

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Ashry

Strange

2017

Eur Respir Rev

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Since the discovery of severe alpha-1 antitrypsin deficiency as a genetic risk factor for emphysema, there has been ongoing debate over whether individuals with intermediate deficiency with one protease inhibitor Z allele (PiMZ, or MZ) are at some risk for emphysema. This is important, because MZ individuals comprise 2-5% of the general population. In this review we summarise the evidence about the risks of the MZ population to develop emphysema or asthma. We discuss the different study designs that have tried to answer this question. The risk of emphysema is more pronounced in case-control than in population-based studies, perhaps due to inadequate power. Carefully designed family studies show an increased risk of emphysema in MZ smokers. This is supported by the rapid decline in lung function of MZ individuals when compared to the general population after massive environmental exposures. The risk of asthma in MZ subjects is less studied, and more literature is needed before firm conclusions can be made. Augmentation therapy in MZ individuals is not supported by any objective studies. MZ smokers are at increased risk for emphysema that is more pronounced when other environmental challenges are present.

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Section: Risk Of Asthma In the Mz Populationmentioning

confidence: 99%

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Ashry

Strange

2017

Eur Respir Rev

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“…MMPs and their tissue inhibitors (TIMPs) are considered to play important roles in nasal polyp formation [36]. MMP-9, secreted by epithelial cells, EOS, mast cells and activated neutrophils, plays a critical role in tissue remodeling in CRS through decomposing the components of ECM.…”

Section: Discussionmentioning

confidence: 99%

“…Higher levels of MMP-9 and low levels of TIMP-1 were observed in patients with CRSwNP. Meanwhile, MMPs were also found to participate in regulating inflammatory cells infiltration and microvascular permeability in allergic disorders including AR and asthma [36, 38]. Increased expression of MMP-9 and ratio of MMP-9/TIMP-1 were observed in AR.…”

Section: Discussionmentioning

confidence: 99%

Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps

Xiang

Zhang

et al. 2018

Eur Arch Otorhinolaryngol

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BackgroundAllergic rhinitis (AR) has been reported to be associated with chronic rhinosinusitis (CRS). The objective of this study was to investigate the effect of AR on nasal mucosa remodeling in CRS.MethodsPatients were enrolled and divided into the following groups: CRS with nasal polyps (NP) with allergic rhinitis (AR)(CRSwNPwAR; n = 20), CRS with NP without AR (CRSwNPsAR; n = 20), CRS without NP with AR (CRSsNPwAR; n = 20), CRS without NP without AR (CRSsNPsAR; n = 20), AR without CRS (AR; n = 20) and controls (n = 14). Eosinophil infiltration, mucus production, and collagen deposition were examined by hematoxylin and eosin, periodic acid schiff and masson’s trichrome staining, respectively. VEGF-A and microvessel density were detected by immunohistochemistry. The expression of remodeling markers, including TGF-β1, MMP-7, MMP-9 and TIMP-1 were measured by Western blot.ResultsThe expression of remodeling factors, including VEGF-A, CD31, CD34 and TIMP-1 were significantly increased in CRSwAR compared to CRSsAR. Goblet cell hyperplasia, as well as VEGF-A, CD31, CD34, and MMP-9 expression were significantly higher in CRSwNPwAR compared to CRSwNPsAR. However, the expression of collagen fibers, MMP-7 and TGF-β1 were significantly higher in CRSsNPwAR compared to CRSsNPsAR.ConclusionsAR could enhance the remodeling process in CRS. Moreover, AR had different effects on CRSwNP and CRSsNP.

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“…Furthermore, local expression and activity of individual MMPs may vary in different airway compartments, thus adding complexity to the network of allergic inflammatory response. [61,78,122] Accordingly, the distribution of MMP-2, MMP-9 and MMP-12 in bronchial wall was shown to differ between large and small airways. Moreover, it varied between healthy controls and patients with asthma, and further changed depending on severity of disease.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinases in Asthma-Associated Airway Remodeling – Dr. Jekyll or Mr. Hyde ?

Grzela¹,

Strzelak²,

Zagórska³

et al. 2016

Asthma - From Childhood Asthma to ACOS Phenotypes

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Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma

Abstract: Our findings suggest shared pathomechanisms behind asthma and CRSwNP. Contrasting local vs systemic results reflect a different ability of healthy mucosa to react to exogenous stimuli, possibly indicating a protective function of MMP-9 and possibly also MMP-8 in the airways.

Cited by 11 publications

References 49 publications

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps

Matrix Metalloproteinases in Asthma-Associated Airway Remodeling – Dr. Jekyll or Mr. Hyde ?

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