Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

“…Furthermore, a positive correlation was found between fractional changes in malondialdehyde, a marker of oxidative stress, and MMP-9 in patients with acute coronary syndrome 12 . TIMP-1 is a natural inhibitor of MMP, especially pro-MMP-9, acting to maintain the structural integrity of basement membranes and protects them from degeneration 14 .…”

“…MMPs are associated with cardiovascular disease and atherosclerosis ; in particular, MMP-2 and MMP-9 play important roles in the progression of atherosclerosis 11 , and MMP-9 activity is associated with oxidative stress in acute coronary syndrome 12 . Our previous studies showed that plasma MMP-9 activity is signi cantly higher and accompanied by aortic lipid deposition in SHHR compared to Sprague-Dawley SD control rats 5 .…”

Matrix Metalloproteinase-9 for the Earliest Stage Acute Coronary Syndrome - Comparison With High-Sensitivity Troponin T -

“…The time interval (median, 25 th and 75 th percentiles) from symptom onset to arrival at the ER (point 1), the start of CAG (point 2), the termination of PCI (point 3), and hospital discharge (point 7) was 82 min, 64 min, and 165 min, 124 min, 100 min and 187 min, 203 min, 167 min, and 247 min and 15 days, 12 days and 19 days, respectively. Time from onset to discharge from hospital (days) 15 (12)(13)(14)(15)(16)(17)(18)(19) Data given as n (%), mean ± SD or median (25 th -75 th percentile). ER, emergency room; CAG, coronary angiography; PCI, percutaneous coronary intervention.…”

“…11,13,14 Levels of MMP-9 especially those in coronary circulation, are significantly higher in ACS than in control subjects. [15][16][17][18] Previous studies, which evaluated plaque rupture using intravascular ultrasound and virtual histology intravascular ultrasound, indicated that MMP-9 levels were significantly higher in ACS patients with plaque rupture than those without. 19, 20 Thus, previous studies have provided evidence that MMP-9 reflects atherosclerotic plaque rupture or vulnerability, but the diagnostic value or time-dependent changes of MMP-9 at the earliest stage of ACS have not been compared with other biomarkers.…”

Increase in Matrix Metalloproteinase-2 and 9 in the Liver of Nonalcoholic Steatohepatitis (NASH) Model Rats

“…MMPs are associated with liver brosis ; in particular, MMP-2 and MMP-9 play important roles in the progression of liver brosis 15 , and MMP-9 activity and expression are associated with oxidative stress 16 . Our previous studies showed that mRNA expression of MMP-9 in white blood cells WBCs is signi cantly higher in SHHR-HFDS compared to other rats 11 .…”