Matrix Metalloproteinase-9 for the Earliest Stage Acute Coronary Syndrome  - Comparison With High-Sensitivity Troponin T -

Kobayashi, Nobuaki; Hata, Noritake; Kume, Noriaki; Yokoyama, Shinya; Shinada, Tetsuro; Tomita, Kazunori; Kitamura, Mitsunobu; Shirakabe, Akihiro; Inami, Toru; Yamamoto, Masanori; Seino, Yoshihiko; Mizuno, Kyoichi

doi:10.1253/circj.cj-11-0640

Cited by 40 publications

(40 citation statements)

References 30 publications

(24 reference statements)

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“…10 Such a thin fibrous cap has been reported to have extracellular matrix proteins degraded by proteolytic enzymes such as neutrophil elastase, plasminogen activators, and matrix metalloproteinases secreted from such activated inflammatory cells as macrophages and neutrophils, 17 and be characterized by infiltration of those activated inflammatory cells. 18 During such a condition of inflammation, they have been also shown to secrete myeloperoxidase (MPO), which catalyzes the conversion of chloride and hydrogen peroxide to hypochlorous acid (HOCl).…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde-Modified Low-Density Lipoprotein Is a Useful Marker to Identify Patients With Vulnerable Plaque

Tajika

Okamatsu

Takano

et al. 2012

Circ J

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Section: Discussionmentioning

confidence: 99%

Malondialdehyde-Modified Low-Density Lipoprotein Is a Useful Marker to Identify Patients With Vulnerable Plaque

Tajika

Okamatsu

Takano

et al. 2012

Circ J

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“…14,15 Therefore, local inflammatory activity is thought to have some impact on early clinical presentation. However, no studies have addressed the impact of in vivo local inflammatory activities on the early clinical presentation in patients with acute MI.…”

Section: Nishiguchi Et Almentioning

confidence: 99%

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment–Elevation Myocardial Infarction

Nishiguchi

Tanaka

Taruya

et al. 2016

ATVB

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Objective-Early clinical presentation of ST-segment-elevation myocardial infarction (STEMI) and non-ST-segmentelevation myocardial infarction affects patient management. Although local inflammatory activities are involved in the onset of MI, little is known about their impact on early clinical presentation. This study aimed to investigate whether local inflammatory activities affect early clinical presentation. Approach and Results-This study comprised 94 and 17 patients with MI (STEMI, 69; non-STEMI, 25) and stable angina pectoris, respectively. We simultaneously investigated the culprit lesion morphologies using optical coherence tomography and inflammatory activities assessed by shedding matrix metalloproteinase 9 (MMP-9) and myeloperoxidase into the coronary circulation before and after stenting. Prevalence of plaque rupture, thin-cap fibroatheroma, and lipid arc or macrophage count was higher in patients with STEMI and non-STEMI than in those with stable angina pectoris.Red thrombus was frequently observed in STEMI compared with others. Local MMP-9 levels were significantly higher than systemic levels (systemic, 42.

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“…This study indicates that plasma levels of MMP-9 increase approximately 80 minutes after the onset of ACS and sustain for 24 h thereafter. On the other hand, serum levels of hs-TnT peaked at 12-24 h after ACS onset [52].…”

Section: Inokubo Et Al Also Reportedmentioning

confidence: 97%

Heart Remodelation: Role of MMPs

Pytliak¹,

Vaník²,

Bojčík³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Myocardium is comprised of a number of cell types. Although most plentiful by volume, cardiac myocytes are greatly outnumbered by nonmyocyte cells, the latter constituting approximately 70% of all myocardial cells, of which approximately 90% are cardiac fibroblasts (CFBs). To maintain the integrity of the cardiac extracellular matrix (ECM) is one of the primary functions of cardiac fibroblasts. ECM represents a network structure that provides the structural and functional integrity to the heart. Besides that, it also contains a high number of cytokines and growth factors with effects on cardiac function and cardiac cells. Cardiac ECM also mediates the mechanical connection between the cardiomyocytes, CFBs, and blood. In addition to producing ECM proteins, CFBs also produce ECM-regulatory proteins -matrix metalloproteinases (MMPs), which can degrade ECM proteins -and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). To date, 26 MMPs have been cloned and characterized in vertebrates. From these, MMP1, MMP3, MMP8, MMP13, MMP2, MMP9, MMP12, MMP28, and the membrane-type MMPs (MT1-MMP/MMP14) have been identified to be involved in the myocardial remodeling. The role of higher MMPs in the cardiovascular system is less well explored.

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Matrix Metalloproteinase-9 for the Earliest Stage Acute Coronary Syndrome - Comparison With High-Sensitivity Troponin T -

Cited by 40 publications

References 30 publications

Malondialdehyde-Modified Low-Density Lipoprotein Is a Useful Marker to Identify Patients With Vulnerable Plaque

Malondialdehyde-Modified Low-Density Lipoprotein Is a Useful Marker to Identify Patients With Vulnerable Plaque

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment–Elevation Myocardial Infarction

Heart Remodelation: Role of MMPs

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