Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry

Alcántara-Durán, Jaime; Moreno‐González, David; Gilbert-López, Bienvenida; Molina‐Díaz, Antonio; García-Reyes, Juan F.

doi:10.1016/j.foodchem.2017.10.083

Cited by 58 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The use of a one-point standard addition was shown to be suitable for the accurate determination of the analytes and reduction of the workload, which constitutes a main advantage for using the method in routine analysis. Alcántara-Durán and co-workers [49] developed a multi-residue method, based on an Orbitrap instrument, for the analysis of 87 veterinary drugs in honey, veal muscle, egg and milk. By optimizing the parameters of the method and applying a dilution factor of 100 to the sample, matrix effects were completely removed for all the compounds and matrices tested.…”

Section: Analysis Of Veterinary Drug Residuesmentioning

confidence: 99%

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Gavage

Delahaut

Gillard

2021

Foods

View full text Add to dashboard Cite

During the last decade, food, feed and environmental analysis using high-resolution mass spectrometry became increasingly popular. Recent accessibility and technological improvements of this system make it a potential tool for routine laboratory work. However, this kind of instrument is still often considered a research tool. The wide range of potential contaminants and residues that must be monitored, including pesticides, veterinary drugs and natural toxins, is steadily increasing. Thanks to full-scan analysis and the theoretically unlimited number of compounds that can be screened in a single analysis, high-resolution mass spectrometry is particularly well-suited for food, feed and water analysis. This review aims, through a series of relevant selected studies and developed methods dedicated to the different classes of contaminants and residues, to demonstrate that high-resolution mass spectrometry can reach detection levels in compliance with current legislation and is a versatile and appropriate tool for routine testing.

show abstract

Section: Analysis Of Veterinary Drug Residuesmentioning

confidence: 99%

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Gavage

Delahaut

Gillard

2021

Foods

View full text Add to dashboard Cite

show abstract

“…Recently, Alcántara‐Durán et al. [46] used, for the first time, a nano‐LC‐HRMS for the analysis of 87 multiresidue veterinary drugs in milk, egg, veal muscle, and honey. After optimizing the two sample treatments employed, QuEChERS and salting‐out supported liquid extraction (SOSLE), veterinary drugs were separated in a capillary column PepMap® C18 (75 μm id × 150 mm; 3 μm particle size).…”

Section: Residues and Contaminants In Food Analysismentioning

confidence: 99%

Miniaturized liquid chromatography applied to the analysis of residues and contaminants in food: A review

2020

View full text Add to dashboard Cite

Miniaturized liquid chromatography applied to the analysis of residues and contaminants in food: A review The humankind is pretty dependent on food to control several biological processes into the organism. As the world population increases, the demand for foodstuffs follows the same trend claiming for a high food production situation. For this reason, a substantial amount of chemicals is used in agriculture and livestock husbandries every year, enhancing the likelihood of contaminated foodstuffs being commercialized. This outlook becomes a public health concern; thus, the governmental regulatory agencies impose laws to control the residues and contaminants in food matrices. Currently, one of the most important analytical techniques to perform it is LC. Despite its already recognized effectiveness, it is often time consuming and requires significant volumes of reagents, which are transformed into toxic waste. In this context, miniaturized LC modes emerge as a greener and more effective analytical technique. They have remarkable advantages, including higher sensitivity, lower sample amount, solvent and stationary phase requirements, and more natural coupling to MS. In this review, most of the critical characteristics of them are discussed, focusing on the benchtop instruments and their related analytical columns. Additionally, a discussion regarding the last 10 years of publications reporting miniaturized LC application for the analysis of natural and industrial food samples is categorized. The main chemical classes as applied in the crops are highlighted, including pesticides, veterinary drugs, and mycotoxins.

show abstract

“…The traditional methods for pesticide and veterinary drug residues determination are usually based on instrumental techniques such as gas chromatography (GC), high performance liquid chromatography (HPLC), or chromatographic methods coupled with mass spectrometry (MS) detectors [8]. These methods provide abundant qualitative and quantitative information of the residues with high accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…These methods provide abundant qualitative and quantitative information of the residues with high accuracy. However, these systems are limited by complicated sample pre-treatments and require highly trained technicians and expensive equipment [8]. On the other hand, rapid methods such as immunoassays [9], spectroscopic analyses [10], and electrochemical techniques [11] provide relatively convenient and highly sensitive strategies for the determination of pesticides and veterinary drugs.…”

Section: Introductionmentioning

confidence: 99%

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

et al. 2020

View full text Add to dashboard Cite

The excessive use or abuse of pesticides and veterinary drugs leads to residues in food, which can threaten human health. Therefore, there is an extremely urgent need for multi-analyte analysis techniques for the detection of pesticide and veterinary drug residues, which can be applied as screening techniques for food safety monitoring and detection. Recent developments related to rapid multi-residue detection methods for pesticide and veterinary drug residues are reviewed herein. Methods based on different recognition elements or the inherent characteristics of pesticides and veterinary drugs are described in detail. The preparation and application of three broadly specific recognition elements—antibodies, aptamers, and molecular imprinted polymers—are summarized. Furthermore, enzymatic inhibition-based sensors, near-infrared spectroscopy, and SERS spectroscopy based on the inherent characteristics are also discussed. The aim of this review is to provide a useful reference for the further development of rapid multi-analyte analysis of pesticide and veterinary drug residues.

show abstract

Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry

Cited by 58 publications

References 33 publications

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Miniaturized liquid chromatography applied to the analysis of residues and contaminants in food: A review

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

Contact Info

Product

Resources

About