Mathematical models and lymphatic filariasis control: endpoints and optimal interventions

Michael, Edwin; Malecela‐Lazaro, Mwele N.; Kabali, Conrad; Snow, L. C.; Kazura, James W.

doi:10.1016/j.pt.2006.03.005

Cited by 73 publications

(92 citation statements)

References 49 publications

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“…29 Furthermore, it has been reported that even a lower drug coverage can achieve the set control criteria with the inclusion of a vector control component to MDA, therefore decreasing the number of years required to attain the target of infection elimination. 30 Thus, we believe that the integration of vector control with MDA can decrease the time required for elimination by complementing the benefits brought about by MDA. The maintenance of low transmission levels for a sufficiently long period to interrupt transmission is a more affordable and sustainable way to eliminate filariasis, especially when communities can be empowered to carry out simple vector control operations along with MDA.…”

Section: Role Of Vector Control In Filariasis Eliminationmentioning

confidence: 99%

Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

Sunish

Rajendran

Mani

et al. 2007

Bull World Health Organ

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Objective To determine the role of vector control in further decreasing the transmission of bancroftian filariasis achieved by mass drug administration and the long-term impact on filariometric indices. Methods Three rounds of annual mass drug administration, with diethylcarbamazine and ivermectin, were complemented by vector control (mainly using polystyrene beads) in villages of Tirukoilur, south India, during 1995-99. Subsequently, drug administration is being carried out with diethylcarbamazine and albendazole or diethylcarbamazine alone. We evaluated the impact of mass drug administration used alone or in conjunction with vector control (from 1995 to 2005) on vector transmission indices (such as transmission intensity index, monthly biting rate, monthly transmission potential and annual transmission potential). We analysed data on filarial infection in the community to estimate the prevalence of microfilaraemia and antigenaemia using c² analysis and Fisher's exact test. Findings Vector density greatly decreased in villages where vector control was used as an adjunct to mass drug administration and almost no infective mosquitoes were found in the small numbers still remaining. Filarial antigenaemia was low and continued to decrease significantly in the age group 15-25 years in villages receiving mass drug administration with vector control in contrast to villages receiving only mass drug administration. Conclusion The gains of mass drug administration were sustained only with the integration of vector control measures. We advocate the incorporation of vector control in the Global Programme to Eliminate Lymphatic Filariasis as it can potentially decrease the time required for eliminating lymphatic filariasis. Une traduction en français de ce résumé figure à la fin de l'article. Al final del artículo se facilita una traducción al español.

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Section: Role Of Vector Control In Filariasis Eliminationmentioning

confidence: 99%

Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

Sunish

Rajendran

Mani

et al. 2007

Bull World Health Organ

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“…Mathematical models that simulate LF transmission 3,4 and GPELF guidelines emphasize the importance of achieving high MDA coverage rates. 5,6 Reported MDA coverage rates vary, [7][8][9] and compliance rates (percentage of people who report having taken the medications) are sometimes much lower than coverage rates (percentage of people who received the medications) reported by public health authorities.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Compliance on the Impact of Mass Drug Administration for Elimination of Lymphatic Filariasis in Egypt

Elaziz¹,

Helmy²,

Farid³

et al. 2007

The American Journal of Tropical Medicine and Hygiene

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Abstract. We studied effects of compliance on the impact of mass drug administration (MDA) with diethylcarbamazine and albendazole for lymphatic filariasis (LF) in an Egyptian village. Baseline microfilaremia (mf) and filarial antigenemia rates were 11.5% and 19.0%, respectively. The MDA compliance rates were excellent (> 85%). However, individual compliance was highly variable; 7.4% of those surveyed after five rounds of MDA denied having ever taken the medications and 52.4% reported that they had taken all five doses. The mf and antigenemia rates were 0.2% and 2.7% in those who reported five doses of MDA and 8.3% and 13.8% in those who reported zero doses. There was no significant difference in residual infection rates among those who had taken two or more doses. These results underscore the importance of compliance for LF elimination programs based on MDA and suggest that two ingested doses of MDA are as effective as five doses for reducing filariasis infection rates.

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“…The first result of import is the finding that simply increasing VC coverage to 80% under existing MDA coverages will not accelerate the meeting of LF elimination at the country level (Table 5). This is unsurprising, given that insecticide bed net coverages used in the baseline simulations across the majority of IUs within the present countries were already at values as high as 60% on average; as we highlighted before [12,64,65], increasing VC coverages by moderate amounts when MDA coverages are already at moderately high levels will not lead to significant impacts on timelines to elimination due to the inherently greater impact of chemotherapy versus VC in reducing LF infection. By contrast, but for the same reason, switching to MDA based either on biannual drug delivery or annual IDA regimens significantly accelerated the achievement of parasite elimination in all countries.…”

Section: Discussionmentioning

confidence: 78%

Continental-Scale, Data-Driven Predictive Assessment of Eliminating the Vector-Borne Disease, Lymphatic Filariasis, in Sub-Saharan Africa by 2020

Michael¹,

Singh²,

Mayala³

et al. 2018

Journal of Vascular Surgery: Venous and Lymphatic Disorders

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Mathematical models and lymphatic filariasis control: endpoints and optimal interventions

Cited by 73 publications

References 49 publications

Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

The Effect of Compliance on the Impact of Mass Drug Administration for Elimination of Lymphatic Filariasis in Egypt

Continental-Scale, Data-Driven Predictive Assessment of Eliminating the Vector-Borne Disease, Lymphatic Filariasis, in Sub-Saharan Africa by 2020

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