Mathematical modelling of flow-injection systems

Band broadening in size-exclusion chromatography of polydisperse samples

“…Several equations have been suggested in the literature, which predict σ 2 tube to be much lower than predicted by Eq. (21) [25,26]. Recent experimental results obtained with dextrans yield dispersion values that are up to a thousand times lower than predicted by the Taylor equation [27].…”

proFIA: a data preprocessing workflow for flow injection analysis coupled to high-resolution mass spectrometry

“…The main steps of the workflow are ( Fig. 2 (Kolev, 1994;Nanita, 2013) is fitted to the bands with high intensities and low matrix effect and baseline d. Quantification and solvent filtering: For each m/z band, the peak borders in the time dimension are determined by using the sample peak model; The intensity is computed as the area under the smoothed signal; The noise model is used to filter out features which are not signficantly distinct from noise 2. Feature grouping (between sample files) by using a kernel density in the m/z dimension 3.…”

Mathematical modeling of dispersion in single interface flow analysis

“…Signal processing was performed with Matlab version 6.5 (MathWorks, Natick, MA). The principles of which FIA is based are relatively simple and have been described thoroughly by many authors [2,8]. Mass transfer in FIA systems can have convective or diffusion origin.…”

“…The single interface flow system comprised two syringes pumps (Burette 1 S, Crison, Alella, Spain), one three-way solenoid valve 161 T031 (NResearch Inc., West Caldwell, USA), a USB-4000 fiber optic wavelength scanning spectrophotometer (Ocean Optics, Dunedin, USA) equipped with 10-mm optical path flow-cells with different inner volumes (8,30 or 60 L), reaction coils with different configuration and internal diameter (0.5 and 0.8 mm) and flow lines with 0.5 or 0.8 mm internal diameter made of PTFE tubing. Home made connectors and confluence points were also used.…”

“…In this context, and mostly for FIA, different models have been proposed comprising both "black-box" and first principles models (probabilistic and deterministic) as described in a review by Kolev [8]. More recently by Pai et al adopted a dispersion-convolution model for simulating peak shapes in a single-line FIA system [9].…”