Mathematical Modeling of Mucociliary Clearance: A Mini-Review

Xu, Ling; Jiang, Yi

doi:10.3390/cells8070736

Cited by 21 publications

(21 citation statements)

References 104 publications

(100 reference statements)

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“…Under the cyclic beatings of cilia including a fast effective stroke and a slow recovery stroke (10~15 Hz), the inhaled particles and pathogens can be trapped in the airway mucus and eliminated from the airway system (Fig. 1) (Loreng and Smith, 2017;McAuley et al, 2019;Ridley and Thornton, 2018;Roy et al, 2014;Sanderson and Sleigh, 1981;Widdicombe, 1997;Xu and Jiang, 2019b).…”

Section: Mucociliary Clearance In Healthy Subjects and Covid-19 Patientsmentioning

confidence: 99%

“…Up to date, enhanced expression of various mucins particularly MUC1, MUC2, and MUC4, FIGURE 1. Mucociliary clearance (MCC) acts as a protective barrier in airways during SARS-CoV-2 infection, adapted from (Chatterjee et al, 2020;Denneny et al, 2020;Hattrup and Gendler, 2008;Kuek and Lee, 2020;Xu and Jiang, 2019b). MCC consists of airway mucus and respiratory cilia.…”

Section: Hypersecretion Of Airway Mucins In Covid-19 Patientsmentioning

confidence: 99%

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Toward an optimized strategy of using various airway mucus clearance techniques to treat critically ill COVID-19 patients

Luo¹,

Ni²,

Sun³

et al. 2022

Biocell

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Coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is still threatening the human life and society throughout the world. For those critically ill patients, mechanical ventilation (MV) is essential to provide life support during treatment. However, both the virus infection and MV disrupt the balance between secretion and elimination of airway mucus and lead to mucus accumulation in the lung. Postmortem examination verified that the lungs in patients died of COVID-19 are indeed filled with sticky mucus, suggesting a great need to improve airway mucus clearance in critically ill COVID-19 patients. Therefore, it may be helpful to comprehensively review the current understanding regarding the changes of biochemical and rheological features of airway mucus associated with the disease, as well as the physiological principles and algorithm to decide airway clearance techniques suitable for the critically ill COVID-19 patients. Based on these considerations, optimized strategies may be developed to eliminate the airway mucus accumulated in the airways of critically ill COVID-19 patients.

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Section: Mucociliary Clearance In Healthy Subjects and Covid-19 Patientsmentioning

confidence: 99%

Section: Hypersecretion Of Airway Mucins In Covid-19 Patientsmentioning

confidence: 99%

Toward an optimized strategy of using various airway mucus clearance techniques to treat critically ill COVID-19 patients

Luo¹,

Ni²,

Sun³

et al. 2022

Biocell

View full text Add to dashboard Cite

show abstract

“…This system constitutes the 1st line of innate defense, and is considered the host defense mechanism for the lungs. This process is called mucociliary clearance [ 53 , 54 ].…”

Section: Clinical Significance Of Mucin In Copdmentioning

confidence: 99%

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

2020

Molecules

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Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality globally. Studies show that airway mucus hypersecretion strongly compromises lung function, leading to frequent hospitalization and mortality, highlighting an urgent need for effective COPD treatments. MUC5AC is known to contribute to severe muco-obstructive lung diseases, worsening COPD pathogenesis. Various pathways are implicated in the aberrant MUC5AC production and secretion MUC5AC. These include signaling pathways associated with mucus-secreting cell differentiation [nuclear factor-κB (NF-κB)and IL-13-STAT6- SAM pointed domain containing E26 transformation-specific transcription factor (SPDEF), as well as epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR)], and signaling pathways related to mucus transport and excretion-ciliary beat frequency (CBF). Various inhibitors of mucus hypersecretion are in clinical use but have had limited benefits against COPD. Thus, novel therapies targeting airway mucus hypersecretion should be developed for effective management of muco-obstructive lung disease. Here, we systematically review the mechanisms and pathogenesis of airway mucus hypersecretion, with emphasis on multi-target and multi-link intervention strategies for the elucidation of novel inhibitors of airway mucus hypersecretion.

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“…( and is considered the host defense mechanism for the lungs. This process is called mucociliary clearance [53,54].…”

Section: Mucus Hydrationmentioning

confidence: 99%

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

2020

Preprint

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Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality globally. Studies show that airway mucus hypersecretion strongly compromises lung function, leading to frequent hospitalization and mortality, highlighting an urgent need for effective COPD treatments. MUC5AC is known to contribute to severe muco-obstructive lung diseases, worsening COPD pathogenesis. Various pathways are implicated in the aberrant MUC5AC production and secretion MUC5AC. These include signaling pathways associated with mucus-secreting cell differentiation [ nuclear factor-κB (NF-кB)and IL-13-STAT6- SAM pointed domain containing E26 transformation-specific transcription factor (SPDEF), as well as epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR)], and signaling pathways related to mucus transport and excretion-ciliary beat frequency (CBF). Various inhibitors of mucus hypersecretion are in clinical use but have had limited benefits against COPD. Thus, novel therapies targeting airway mucus hypersecretion should be developed for effective management of muco-obstructive lung disease. Here, we systematically review the mechanisms and pathogenesis of airway mucus hypersecretion, with emphasis on multi-target and multi-link intervention strategies for the elucidation of novel inhibitors of airway mucus hypersecretion.

show abstract

Mathematical Modeling of Mucociliary Clearance: A Mini-Review

Cited by 21 publications

References 104 publications

Toward an optimized strategy of using various airway mucus clearance techniques to treat critically ill COVID-19 patients

Toward an optimized strategy of using various airway mucus clearance techniques to treat critically ill COVID-19 patients

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

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