2020
DOI: 10.3390/molecules25194437
|View full text |Cite
|
Sign up to set email alerts
|

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease

Abstract: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality globally. Studies show that airway mucus hypersecretion strongly compromises lung function, leading to frequent hospitalization and mortality, highlighting an urgent need for effective COPD treatments. MUC5AC is known to contribute to severe muco-obstructive lung diseases, worsening COPD pathogenesis. Various pathways are implicated in the aberrant MUC5AC production and secretion MUC5AC. These include signaling pathway… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
23
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 30 publications
(23 citation statements)
references
References 107 publications
(128 reference statements)
0
23
0
Order By: Relevance
“…Five hub genes, including MUC5AC, BCL6, TET2, NFE2L2, and VDR were detected from the PPIs network. MUC5AC, BCL6, NFE2L2, and VDR have been documented as having an association with the pathogenesis of lung diseases [ [39] , [40] , [41] , [42] ]. In module analysis, VDR and NFE2l2 were clustered together which was performed to suggest more effective drug compounds.…”
Section: Discussionmentioning
confidence: 99%
“…Five hub genes, including MUC5AC, BCL6, TET2, NFE2L2, and VDR were detected from the PPIs network. MUC5AC, BCL6, NFE2L2, and VDR have been documented as having an association with the pathogenesis of lung diseases [ [39] , [40] , [41] , [42] ]. In module analysis, VDR and NFE2l2 were clustered together which was performed to suggest more effective drug compounds.…”
Section: Discussionmentioning
confidence: 99%
“…In patients with COPD, the overexpression and hypersecretion of mucins can increase the concentrations of the contents up to 15%, resulting in viscous and elastic mucus being cleared difficultly and adhering more readily to the airway [ 26 ]. Therefore, excess mucus aggravates airway obstruction, increases airway reactivity, and reduces pulmonary function [ 27 ]. Approximately 95% of the total mucins secreted in the airway epithelium was produced by goblet cells and can be detected with AB/PAS staining [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…In COPD, these mechanisms may be impaired, accompanied by mucus hypersecretion. Mucus hypersecretion is associated with mucins, of which MUC5AC is considered the most important [31,32]. MUC5AC is produced predominantly by goblet cells of the bronchial epithelium [33].…”
Section: The Innate Immune Function Of Airway Epithelial Cellsmentioning
confidence: 99%