The bevel gear transmission with crossed axes is widely used, but there are the difficulty of tooth profile calculation and modeling in the design and manufacturing process. This paper analyzes firstly the parameter solving equation of the bevel gear pair with arbitrary crossed axes. Based on the meshing principle of the bevel gear pair and numerical analysis method, the meshing equations of the bevel gear pair with crossed axes are derived, which provide the calculation models for the design of spatial bevel gear tooth surface. Taking the bevel gear pair with crossed axes in two kinds of the knotter as two design examples, the geometric parameters of the bevel gear pair in the knotter are solved, and the mathematical models of the tooth surface are programmed and calculated by using MATLAB. Through the graphic display of the tooth surface point set under MATLAB software and the 3D modeling function of Pro/Engineering software, the accurate 3D models of the bevel gear tooth surface are established. The meshing transmission simulations of the established bevel gear pair are respectively carried out by using ADAMS, and their physical prototype and transmission tests are also implemented. The test results showed that the transmission of the designed bevel gear pair is accurate and stable, which proves the correctness of the derived calculation model of the tooth surface of the bevel gear with crossed axes.