Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

Freguia, Christian Furlan; Marriott, Amber L.; Gill, Daphne A.; Kaleko, Michael

doi:10.1016/j.bbr.2020.112701

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…A maternal high-fat diet can induce long-term cognitive deficits in the next generation ( 225 ). However, maternal treatment with oral intestinal alkaline phosphatase, an enzyme that tightens the gut barrier and promotes the growth of commensal symbionts by detoxifying anti-inflammatory agents, mitigated high-fat diet-induced cognitive disorders in offspring mice ( 226 ). When there is antibiotic exposure during pregnancy, more severe anxiety and less social interactions were observed in rat offspring ( 202 ), and similar results were found in a human study ( 203 ).…”

Section: Maternal Gut Microbiota: the Role In Offspring Healthmentioning

confidence: 99%

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

Lu,

Shi,

Jiang

et al. 2024

Front. Immunol.

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Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages. Some other evidence has also shown that aberrant maternal gut microbiota increases the risk of various diseases in the offspring, such as allergic and neurodevelopmental disorders, through the immune alignment between mother and fetus and the possible intrauterine microbiota. Probiotics and the high-fiber diet are effective inventions to prevent mothers and fetuses from diseases. In this review, we summarize the role of maternal gut microbiota in the development of pregnancy complications and the health condition of future generations from the perspective of immunology, which may provide new therapeutic strategies for the health management of mothers and offspring.

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Section: Maternal Gut Microbiota: the Role In Offspring Healthmentioning

confidence: 99%

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

Lu,

Shi,

Jiang

et al. 2024

Front. Immunol.

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“…At the same time, recent studies have proved that oral supplementation of IAP to pregnant mothers is of positive significance to the health of infants. A mouse model test found that maternal IAP treatment can alleviate some autism spectrum disorder (ASD)-like symptoms of offspring mice [87]. It is worth noting that the content of ALP in breast milk decreased with lactation time [88].…”

Section: Infant Intestinal Healthmentioning

confidence: 99%

Protective Effect of Alkaline Phosphatase Supplementation on Infant Health

Wang

et al. 2022

Foods

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Alkaline phosphatase (ALP) is abundant in raw milk. Because of its high heat resistance, ALP negative is used as an indicator of successful sterilization. However, pasteurized milk loses its immune protection against allergy. Clinically, ALP is also used as an indicator of organ diseases. When the activity of ALP in blood increases, it is considered that diseases occur in viscera and organs. Oral administration or injecting ALP will not cause harm to the body and has a variety of probiotic effects. For infants with low immunity, ALP intake is a good prebiotic for protecting the infant’s intestine from potential pathogenic bacteria. In addition, ALP has a variety of probiotic effects for any age group, including prevention and treatment intestinal diseases, allergies, hepatitis, acute kidney injury (AKI), diabetes, and even the prevention of aging. The prebiotic effects of alkaline phosphatase on the health of infants and consumers and the content of ALP in different mammalian raw milk are summarized. The review calls on consumers and manufacturers to pay more attention to ALP, especially for infants with incomplete immune development. ALP supplementation is conducive to the healthy growth of infants.

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“…Treatment with L-phenylalanine, an inhibitor of IAP activity, abrogated the protective effects of IAP in HF mice. It was found that maternal treatment using oral IAP attenuated high fat diet (HFD)-induced autism-like cognitive disorder in offsprings [ 23 ]. However, whether the leaky gut phenotype was observed in such offspring and whether IAP reversed it is not known.…”

Section: Iap and Barrier Functionmentioning

confidence: 99%

Role of Intestinal Alkaline Phosphatase in Innate Immunity

Singh

Lin

2021

Biomolecules

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Intestinal alkaline phosphatase (IAP) is a multi-functional protein that has been demonstrated to primarily protect the gut. The role of IAP in maintaining intestinal homeostasis is underscored by the observation that IAP expression is defective in many gastrointestinal-related disorders such as inflammatory bowel disease IBD, necrotizing enterocolitis, and metabolic syndrome and that exogenous IAP supplementation improves the outcomes associated with these disorders. Additionally, studies using transgenic IAP-knock out (IAP-KO) mouse models further support the importance of the defensive role of IAP in the intestine. Supplementation of exogenous IAP and cellular overexpression of IAP have also been used in vitro to dissect out the downstream mechanisms of this protein in mammalian cell lines. Some of the innate immune functions of IAP include lipopolysaccharide (LPS) detoxification, protection of gut barrier integrity, regulation of gut microbial communities and its anti-inflammatory roles. A novel function of IAP recently identified is the induction of autophagy. Due to its critical role in the gut physiology and its excellent safety profile, IAP has been used in phase 2a clinical trials for treating conditions such as sepsis-associated acute kidney injury. Many excellent reviews discuss the role of IAP in physiology and pathophysiology and here we extend these to include recent updates on this important host defense protein and discuss its role in innate immunity via its effects on bacteria as well as on host cells. We will also discuss the relationship between IAP and autophagy and how these two pathways may act in concert to protect the gut.

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Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

Cited by 8 publications

References 33 publications

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

Protective Effect of Alkaline Phosphatase Supplementation on Infant Health

Role of Intestinal Alkaline Phosphatase in Innate Immunity

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