Maternal soy protein isolate diet during lactation programmes to higher metabolic risk in adult male offspring

Brasiel, Poliana Guiomar de Almeida; Ferreira, Maíra Schuchter; Vieira, Adriana Moura; Figueiredo, Mariana Sarto; Lisboa, Patrícia Cristina; Moura, Egberto Gaspar de; Lopes, Fernando César Ferraz; Aguiar, Aline Silva de; Dutra, Sheila Cristina Potente

doi:10.1080/09637486.2020.1754350

Cited by 1 publication

(1 citation statement)

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“…Although the benefits of consuming soya products have been reported in many studies, consuming soya products containing phytoestrogens raises concerns (49) . Studies suggest that they may be associated with endocrine-metabolic dysfunctions in adult life (50) , and maternal consumption of soya protein isolate during lactation worsened the atherogenic indices of the offsprings in adulthood (51) . While soya products are often coming from genetically modified soya seeds whose effect on the body is unknown, more studies are needed to investigate the long-term effects of soya consumption.…”

Section: Limitations Of the Scoping Reviewmentioning

confidence: 99%

The associations of soya intakes with non-communicable diseases: a scoping review of meta-analyses

Yip

Chan

2022

Br J Nutr

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This scoping review aimed to identify published meta-analyses of the associations of dietary soy intakes with cardiovascular, cancer, and diabetes II diseases and the best relative risk estimates. A published novel assessment process combining the well-validated Cochrane Review measures, the AMSTAR 2 checklist, and a published algorithm specifically designed for conducting a scoping review of similar meta-analyses was employed. This scoping review identified and evaluated 28 meta-analysis reports, published between 2000 and 2021, on the associations of soy intakes with cardiovascular, cancer, and diabetes II diseases. It identified 18 significantly negatively associated risk-disease pairs for total soy intakes, four significantly negatively associated risk-disease pairs for unfermented soy intakes, and four significantly negatively associated risk-disease pairs for fermented soy intakes when compared high against low intakes. The largest significant risk decrease found was gastric cancer mortalities with relative risk (RR) 0.49 (95% CI: 0.35, 0.68); followed by colorectal cancer mortalities RR 0.59 (95% CI: 0.41, 0.84); ovarian cancer RR 0.52 (95% CI: 0.42, 0.66); and endocrine-related gynaecological cancer RR 0.61 (95% CI: 0.53, 0.72). The fermented soy intake and gastric cancer risk-disease pair was identified to be significantly positively associated, RR 1.22 (95% CI: 1.02, 1.44) when compared high against low intakes. Four significantly negatively associated risk-disease dose-responses were also identified. Being the products with lower greenhouse gas emission intensities, soy products could be the better dietary alternatives to animal products for reducing cardiovascular, cancer, and diabetes II diseases and helping combat climate change.

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Section: Limitations Of the Scoping Reviewmentioning

confidence: 99%