Maternal serum zinc deficiency in cases of neural tube defect in Gorgan, north Islamic Republic of Iran

Mj, Golalipour; Ma, Vakili; Mansourian, Azad Reza; Mobasheri, Elham

doi:10.26719/2009.15.2.337

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…Zinc deficiency has been widely reported to be associated with NTD risk (Carrillo‐Ponce Mde et al, ; Golalipour et al, ; Dey et al, ). Because the hair Zn concentration in this population was at a comparable level to previous studies (Chojnacka et al, ; Wu et al, ; Gellein et al, ; Hsieh et al, ), we considered that there was no Zn deficiency in study participants.…”

Section: Discussionmentioning

confidence: 99%

Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring

Yan

Wang

et al. 2017

Birth Defects Research

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Section: Discussionmentioning

confidence: 99%

Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring

Yan

Wang

et al. 2017

Birth Defects Research

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“…reported a maternal low serum zinc level and a high copper level as an association with NTDs (8). A recent study in Iran reported maternal zinc deficiency to be associated with NTDs (21). However, results of some studies also suggest that zinc deficiency was not related to NTDs (22,23), although population-based case-control studies concluded that the risk of NTDs in infants and foetuses decreased with increasing maternal zinc intake (24,25).…”

Section: Discussionmentioning

confidence: 99%

Maternal and Neonatal Serum Zinc Level and Its Relationship with Neural Tube Defects

Dey

Shahidullah

Mannan

et al. 2010

J Health Popul Nutr

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Neural tube defect (NTD) is a multi-factorial disorder in which nutritional, genetic and environmental factors are involved. Among the nutritional factors, low level of serum zinc has been reported from different parts of the world. This hospital-based case-control study was conducted with the objective of finding the relationship between serum zinc level in newborns and their mothers and NTDs in a Bangladeshi population. The study was conducted during August 2006–July 2007 at the Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka. In total, 32 mothers and their newborns with NTDs were included as cases and another 32 mothers with their normal babies were included as controls. Concentration of serum zinc was determined by pyro-coated graphite furnace atomic absorption spectrophotometer (GF-AAS). The mean age of the case and control mothers was 25.28 years and 24.34 years respectively. The mean gestational age of the case newborns was 36.59 weeks and that of the control newborns was 37.75 weeks. The mean serum zinc level of the case and control mothers was 610.2 μg/L and 883.0 μg/L respectively (p<0.01). The mean serum zinc level of the case and control newborns was 723 μg/L and 1,046 μg/L respectively (p<0.01). In both case and control groups, the serum zinc level of the newborns positively correlated with that of the mothers. The serum zinc levels of the mothers and newborns negatively correlated with NTDs. Mothers with serum zinc level lower than normal were 7.66 [95% confidence interval (CI) 2.5-23.28] times more likely to have NTDs compared to the normal zinc level of mothers. After adjusting for the zinc level of the newborns, parity, and age of the mothers, this risk reduced 1.61 times [confidence interval (CI) 95% 0.24-8.77]. On the other hand, the low serum zinc level of the newborns was 7.22 times more associated with NTDs compared to the newborns with the normal serum zinc level, which was statistically significant (p=0.001). After adjusting for other factors, such as maternal age and parity, newborns with the low serum zinc level was found to be 9.186 times more likely to be associated with NTDs compared to newborns with normal serum zinc level. Based on the findings, it may be concluded that the low serum zinc levels of newborns may be associated with NTDs. To confirm these findings, a further study with a larger sample-size is recommended. Moreover, a follow-up study with zinc supplementation to pregnant women and its impact on NTDs is also recommended.

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“…S1). The epidemiology data highlight that lower zinc levels in maternal or fetal tissues are associated with NTDs in Turkey (Çavdar et al, 1991Cengiz et al, 2004;Demir et al, 2017;Zeyrek et al, 2009), Iran (Golalipour et al, 2009), China (Yan et al, 2017), Netherlands (Groenen et al, 2003), England (Buamah et al, 1984;Hinks et al, 1989;Leger et al, 1980), Bangladesh (Dey et al, 2010), Mexico (Carrillo-Ponce Mde et al, 2004) and India (Srinivas et al, 2001) (blue frames in Fig. S1).…”

Section: Introductionmentioning

confidence: 99%

Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

Zhang

Niswander

2018

Development

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Micronutrition is essential for neural tube closure, and zinc deficiency is associated with human neural tube defects. Here, we modeled zinc deficiency in mouse embryos, and used live imaging and molecular studies to determine how zinc deficiency affects neural tube closure. Embryos cultured with the zinc chelator TPEN failed to close the neural tube and showed excess apoptosis. TPEN-induced p53 protein stabilization in vivo and in neuroepithelial cell cultures and apoptosis was dependent on p53. Mechanistically, zinc deficiency resulted in disrupted interaction between p53 and the zinc-dependent E3 ubiquitin ligase Mdm2, and greatly reduced p53 ubiquitylation. Overexpression of human CHIP, a zinc-independent E3 ubiquitin ligase that targets p53, relieved TPEN-induced p53 stabilization and reduced apoptosis. Expression of p53 pro-apoptotic target genes was upregulated by zinc deficiency. Correspondingly, embryos cultured with p53 transcriptional activity inhibitor pifithrin-α could overcome TPEN-induced apoptosis and failure of neural tube closure. Our studies indicate that zinc deficiency disrupts neural tube closure through decreased p53 ubiquitylation, increased p53 stabilization and excess apoptosis.

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Maternal serum zinc deficiency in cases of neural tube defect in Gorgan, north Islamic Republic of Iran

Cited by 10 publications

References 32 publications

Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring

Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring

Maternal and Neonatal Serum Zinc Level and Its Relationship with Neural Tube Defects

Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

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