Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring

Abstract

We concluded that maternal intakes of the four ETMs (Ni, Mo, Zn, and Sn) played an important role in the formation of NTDs in our study population, and that this intake is related to maternal dietary habits.Birth Defects Research 109:234-243, 2017.© 2016 Wiley Periodicals, Inc.

Amniotic fluid levels of selected trace elements and heavy metals in pregnancies complicated with neural tube defects

“…Our study is the first to evaluate Mo levels in amniotic fluid in pregnancies complicated with NTDs. Sn was studied for the first time by Yan et al, who suggested a possible protective effect of Sn on the NTD risk . Our results do not agree with their data in that we observed higher amniotic fluid levels of Sn in pregnancies complicated with NTDs.…”

“…Vazquez‐Salas et al reported a potential negative association between prenatal Mo exposure and infant neurodevelopment . On the contrary, in a study in 191 women with NTD‐affected pregnancies, Yan et al reported that a high Mo level in maternal hair was clearly a protective factor against either anencephaly or spina bifida . Our study is the first to evaluate Mo levels in amniotic fluid in pregnancies complicated with NTDs.…”

“…Decreased or increased amounts of these elements may cause an elevation or a reduction in the incidence of birth defects. It has been reported that some trace elements such as Zn, Se, and Cu are essential for the proper development of the neural tube and the central nervous system . In contrast, some heavy metals such as Al, Hg, Pb, and Cd are known to be teratogenic and toxic to neurodevelopment during the embryogenesis period …”

“…Trace elements and heavy metals, including both essential minerals and toxic metals, have various developmental effects during the embryonic neurulation phase. It has been documented that deficient or increased amounts of these elements may lead to a decrease or increase in the incidence of NTDs . The deficiency of trace elements including zinc (Zn) and selenium (Se) has been investigated in mothers who gave birth to infants affected by NTDs, and a potential risk for the occurrence of NTDs was established .…”

Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

“…S1). The epidemiology data highlight that lower zinc levels in maternal or fetal tissues are associated with NTDs in Turkey (Çavdar et al, 1991Cengiz et al, 2004;Demir et al, 2017;Zeyrek et al, 2009), Iran (Golalipour et al, 2009), China (Yan et al, 2017), Netherlands (Groenen et al, 2003), England (Buamah et al, 1984;Hinks et al, 1989;Leger et al, 1980), Bangladesh (Dey et al, 2010), Mexico (Carrillo-Ponce Mde et al, 2004) and India (Srinivas et al, 2001) (blue frames in Fig. S1).…”