Maternal serum uric acid level and maternal and neonatal complications in preeclamptic women: A cross-sectional study

Abstract

Background: Preeclampsia is associated with maternal and neonatal complications. It has been indicated that increased uric acid might have a predictive role on preeclampsia. Objective: We aimed to investigate the relationship between the level of uric acid with maternal and neonatal complications in women with preeclampsia. Materials and Methods: In this cross-sectional study, 160 singleton preeclamptic women at more than 28 wk gestational age were included. Hemoglobin, hematocrit, platelet count, liver and uric acid tests, and maternal and neonatal complications were assessed. The severity of preeclampsia, placental abruption, preterm labor, thrombocytopenia, elevated alanine aminotransferase and aspartate aminotransferase (ALT and AST), HELLP syndrome, eclampsia and required hospitalization in the ICU was considered as the maternal complication. Fetal complications were: small for gestational age (SGA), intrauterine fetal death, hospitalization in the neonatal intensive care unit, and Apgar score <7 at five minutes. Results: Of our participants, 38 women had severe preeclampsia (23.8%). The mean level of uric acid in women with severe preeclampsia was significantly higher than non-severe preeclampsia (p=0.031), also in those with an abnormal liver test (p=0.009). The mean level of uric acid in women with preterm delivery was significantly higher than women with term delivery (p=0.0001). Also, the level of uric acid had no effect on neonatal hospitalization in neonate invasive care unit. Based on logistic regression, the incidence of severe preeclampsia not affected by decreased or increased serum levels of uric acid. Conclusion: With higher level of uric acid in server preeclampsia we can expected more complications such as hepatic dysfunction and preterm delivery. Thus serum uric acid measurement can be helpful marker for severe preeclampsia.

Serum uric acid: a biochemical prognostic indicator of pregnancy outcomes among pre-eclampsia patients at the federal medical centre, Yenagoa

“…This increased amount of serum uric acid amongst clients with preeclampsia has been reported by several studies and this increased amount is thought to correlate with the severity of the disease condition. 5,10,20,21 Antenatal patients with renal disease were excluded from taking part in this study and as such, it is unlikely that renal disease would have contributed to the higher levels of serum uric acid amongst the study population.…”

Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy

“…In this study, the incidence rate of adverse maternal and neonatal outcomes (premature delivery, caesarean delivery, postpartum hemorrhage, neonatal asphyxia and perinatal death) in the combination group were significantly lower than that in the magnesium sulfate group. A large number of studies on the treatment of HDCP have confirmed that magnesium sulfate combined with other antihypertensive drugs is more effective in preventing ADR of patients with HDCP and improving maternal and neonatal outcomes (23–25).…”

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

“…Studies have reported elevated uric acid levels in pregnancies complicated by preeclampsia and thus of good diagnostic and prognostic value for fetus [9] [26]…”