Serum uric acid: a biochemical prognostic indicator of pregnancy outcomes among pre-eclampsia patients at the federal medical centre, Yenagoa

Obagah, Lukman; Kasia, Benedicta; Jeremiah, Israel; Allagoa, Dennis O.; Aigere, Egbaname E. O. S.; Kotingo, E L; Oriji, Peter Chibuzor

doi:10.18203/2320-1770.ijrcog20204778

Cited by 3 publications

(4 citation statements)

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“…Furthermore, our study found a significant increase in Uric acid levels in PE vs. Control. The finding was similar to those of previous studies [27,28] . The OR of UA was three times higher than control; it might be a risk factor for PE.…”

Section: Discussionsupporting

confidence: 93%

“…Oxidative stress, hypoxic placental tissue, and endothelial dysfunction [30] may further enhance xanthine oxidase levels, thereby causing an increase in serum UA levels. Therefore, it may be used as an early prognostic indicator of the pathophysiology of PE [27] . We could not find any studies showing the association of study parameters (RTL, MDA, and CRP) with an increase in BP (10 mmHg) in PE.…”

Section: Discussionmentioning

confidence: 99%

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Role of circulatory Telomere length, Oxidative stress markers, and inflammatory markers with Increasing Blood pressure in PREECLAMPSIA - A Study in western Uttar Pradesh, India

2022

pnr

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Introduction: PE is a pregnancy-related syndrome with Gestational hypertension and proteinuria. It is caused by improper maternal spiral artery remodelling leading to reduced perfusion to the placenta, promoting exaggerated inflammatory markers CRP, IL 6, TNF alpha, and oxidative stress (OS) tags (MDA) into circulation. Therefore, this study was planned to explore any association between telomere length, inflammatory markers, and oxidative stress markers with change in BP (increase every ten mmHg). To the best of our knowledge, it is the first study exploring this association in preeclamptic patients. Methods: A case-control study included PE cases (n=90) and controls (n=70). RT-PCR measured relative telomere length (RTL) as a T/S ratio. Serum levels of Malondialdehyde (MDA) and C-reactive protein (CRP) by using competitive ELISA and uric acid (UA) levels by autoanalyzer. Results: RTL is significantly(p=.000) reduced in PE compared to control. MDA, CRP, and Uric acid levels significantly(p=.000) increased in cases than in control. Telomere length decreased with the rise in BP, and CRP, MDA, and UA levels increased significantly with an increase in BP. Therefore, we planned to explore the association between telomere length, inflammation, and oxidative stress with every ten mmHg increase in BP. Conclusion: Increasing BP by ten mmHg led to shorter Telomere Length and increased MDA, CRP, and UA levels. Therefore, increasing BP is associated with shorter telomere length, oxidative stress, and inflammation in PE.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Role of circulatory Telomere length, Oxidative stress markers, and inflammatory markers with Increasing Blood pressure in PREECLAMPSIA - A Study in western Uttar Pradesh, India

2022

pnr

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“…The mean SUA of the preeclampsia group was much higher than the normotensive group. This finding was consistent with the study by Sultana et al, Obagah et al and Ugwuanyi et al [38][39][40] This elevated SUA in preeclamptic women supports the theory of hypoxia and ischemia of the placenta tissue that increases substrate for increased uric acid production by xanthine oxidase, coupled with a poor renal clearance of uric acid in preeclampsia.…”

Section: Discussionsupporting

confidence: 92%

Serum uric acid as a prognostic marker for preeclampsia at a tertiary hospital in Port Harcourt, Nigeria

Ngeri

Awoyesuku

Ohaka

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia is a recognized cause of maternal and perinatal morbidity and mortality. Some biomarkers such as uric acid are increased in the presence of the disease. This could serve as a marker of severity and provide a basis for making management decisions. This study sought to determine the association between elevated serum uric acid and adverse pregnancy outcomes in preeclampsia.Methods: A prospective case-control study was carried out on consenting preeclamptic (95) and normotensive (95) pregnant women in their third trimester of pregnancy. Blood samples were taken for serum uric acid estimation at recruitment and delivery. Their Socio-demographic information was collected through a structured proforma. Data were analyzed using Statistical package for social sciences (SPSS) version 23. A p<0.05 was considered statistically significant.Results: The mean serum uric acid level was higher in the preeclamptic than in the normotensive controls (400.0±105.27 versus 256.31±67.18; p=0.001). High serum uric acid levels were associated with a higher incidence of AKI (p=0.005), birth asphyxia (p=0.002), and low birth weight (p=0.006) compared to preeclamptics with normal uric acid levels. The sensitivity of high uric acid in predicting the outcomes was 78-81% while the specificity was 48%. Serum uric acid ≥334 µmol/l was the threshold for predicting adverse outcomes.Conclusions: Women with preeclampsia had significantly higher serum uric acid levels. Hyperuricaemia in preeclampsia was associated with a high incidence of acute kidney injury, Birth asphyxia, and low birth weight. Serum uric acid ≥334 µmol/l was the threshold for the prediction of adverse outcomes.

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“…7 Predictive factors for preeclampsia have been shown to play helpful roles in the prevention, early institution of management, and prognosis of this disorder. [17][18][19] The objective of this study was to determine the incidence, clinical characteristics, maternal and perinatal outcomes of HDP at the Federal medical centre, Yenagoa, Bayelsa State, South-South Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Hypertensive disorders in pregnancy at the federal medical centre, Yenagoa, South-South Nigeria: a 5 year review

et al. 2021

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Background: Hypertensive disorders complicate 5.2%-8.2% of pregnancies, and contribute significantly to perinatal and maternal morbidity and mortality worldwide. To determine the incidence, clinical characteristics, maternal and perinatal outcomes of hypertensive disorders in pregnancy at the Federal medical centre, Yenagoa, Bayelsa State, South-South Nigeria.Methods: This retrospective study was conducted between 1 January, 2016 and 31 December, 2020. Relevant data was retrieved, entered into a pre-designed proforma, and analysed using IBM SPSS version 25.0.Results: Out of the 4,571 obstetric patients that were managed in our Centre in the period under review, 335 of them had HDP, giving an incidence rate of 7.32%.The most common HDP were pre-eclampsia (189, 56.4%) and eclampsia (82, 24.5%), while the least common was chronic hypertension (3, 0.9%). A little more than one-half (171, 51.0%) of the women delivered preterm, with a mean gestational age at delivery of 35.5 weeks. The most common route of delivery was emergency Caesarean section (205, 61.2%). There were three maternal deaths, giving a case fatality rate of 0.9%. Two of the maternal deaths were due to eclampsia, and one, from pre-eclampsia.Conclusions: Women should be adequately counseled to embrace preconception care, and early and regular antenatal care visits, with proper monitoring of blood pressure and urine protein. Prompt diagnosis and management are key in preventing the maternal and perinatal morbidity and mortality that are associated with these disorders.

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Serum uric acid: a biochemical prognostic indicator of pregnancy outcomes among pre-eclampsia patients at the federal medical centre, Yenagoa

Cited by 3 publications

References 7 publications

Role of circulatory Telomere length, Oxidative stress markers, and inflammatory markers with Increasing Blood pressure in PREECLAMPSIA - A Study in western Uttar Pradesh, India

Role of circulatory Telomere length, Oxidative stress markers, and inflammatory markers with Increasing Blood pressure in PREECLAMPSIA - A Study in western Uttar Pradesh, India

Serum uric acid as a prognostic marker for preeclampsia at a tertiary hospital in Port Harcourt, Nigeria

Hypertensive disorders in pregnancy at the federal medical centre, Yenagoa, South-South Nigeria: a 5 year review

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