Maternal serum resistin concentrations in gestational diabetes mellitus and normal pregnancies

Vitoratos, N.; Deliveliotou, Aikaterini; Dimitrakaki, Alexandra; Hassiakos, Dimitrios; Panoulis, Constantinos; Deligeoroglou, Efthimios; Creatsas, George

doi:10.1111/j.1447-0756.2010.01327.x

Cited by 24 publications

(12 citation statements)

References 36 publications

(79 reference statements)

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“…Our data confirm that the adipocyte-derived hormone, adiponectin, is a specific independent predictor of GDM in both obese and non-obese women and directly compares its performance with those of a number of other previously suggested markers such as CRP, SHBG and the adipokines neutrophil gelatinase-associated lipocalin (NGAL), resistin and RBP-4 [14,[17][18][19][20][21][22][23][27][28][29][30][31][32].…”

Section: Discussionsupporting

confidence: 82%

“…Here, adiponectin was the best performing independent predictor of GDM, regardless of BMI grouping. SHBG, RBP-4, CRP and resistin have also been described as potential biomarkers of GDM in numerous publications [14,[17][18][19][20][21][22][23][28][29][30][31]. In this study, however, this potential was confirmed only for SHBG in obese women; in contrast, there was no significant difference in RBP-4, CRP and resistin levels between GDM patients and controls.…”

Section: Discussioncontrasting

confidence: 74%

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First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

et al. 2016

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Aims/hypothesis Gestational diabetes mellitus (GDM) is associated with an increased risk of pre-eclampsia, macrosomia and the future development of type 2 diabetes mellitus in both mother and child. Although an early and accurate prediction of GDM is needed to allow intervention and improve perinatal outcome, no single protein biomarker has yet proven useful for this purpose. In the present study, we hypothesised that multimarker panels of serum proteins can improve firsttrimester prediction of GDM among obese and non-obese women compared with single markers. Methods A nested case-control study was performed on firsttrimester serum samples from 199 GDM cases and 208 controls, each divided into an obese group (BMI ≥27 kg/m 2 ) and a non-obese group (BMI <27 kg/m 2 ). Based on their biological relevance to GDM or type 2 diabetes mellitus or on their previously reported potential as biomarkers for these diseases, a number of proteins were selected for targeted nano-flow liquid chromatography (LC) MS analysis. This resulted in the development and validation of a 25-plex multiple reaction monitoring (MRM) MS assay. Results After false discovery rate correction, six proteins remained significantly different (p<0.05) between obese GDM patients (n=135) and BMI-matched controls (n=139). These included adiponectin, apolipoprotein M and apolipoprotein D. Multimarker models combining protein levels and clinical data were then constructed and evaluated by receiver operating characteristic (ROC) analysis. For the obese, nonobese and all GDM groups, these models achieved marginally higher AUCs compared with adiponectin alone. Conclusions/interpretation Multimarker models combining protein markers and clinical data have the potential to predict women at a high risk of developing GDM.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 74%

First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

et al. 2016

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“…For instance, resistin has been reported to increase in GDM pregnancies from 28-38 weeks of pregnancy [21]. Also of note, there was no significant difference in BMI between women who were diagnosed with GDM and those who avoided recurrence in our cohort.…”

Section: Discussionmentioning

confidence: 44%

Maternal circulating adipokine profile and insulin resistance in women at high risk of developing gestational diabetes mellitus

Guelfi

Ong

et al. 2017

Metabolism

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“…In agreement with the results of two previous studies [ 33 , 34 ], our findings showed that serum resistin levels were similar in the GDM and non- GDM subjects. By contrast, other studies have found lower [ 7 ] or higher [ 15 , 16 ] resistin levels in GDM patients compared to healthy pregnant women. These discrepancies mostly arise from the presence of heterogeneities in the several aspects of aforementioned studies.…”

Section: Discussionmentioning

confidence: 60%

“…Most of these findings showed no difference in the serum resistin level between GDM and normal glucose tolerant (NGT) subjects [ 13 , 14 ]. However, there are other reports indicating increased [ 15 , 16 ] or decreased [ 7 ] serum resistin concentrations in women with GDM compared with NGT pregnant women.…”

Section: Introductionmentioning

confidence: 98%

Resistin – 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus

Takhshid

Zare

2015

J Diabetes Metab Disord

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BackgroundResistin is a circulating adipokine with insulin-antagonizing effects. The aim of this study was to investigate the relationship between the single nucleotide polymorphism (SNP) -420C > G in the resistin gene with serum resistin levels, insulin resistance, and risk of gestational diabetes (GDM) in Iranian population.Method75 GDM patients and 70 healthy pregnant women were enrolled in this study. Genotyping for SNP- 420C > G in the resistin gene was performed by the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Serum resistin and insulin were measured by immunoassay. Blood glucose levels and lipid profile were measured by enzymatic methods. Homeostasis model of assessment for insulin resistance (HOMA-IR) were calculated.ResultGG genotype and G allele of SNP-420C > G were more frequent in GDM patients compared to non-GDM subjects. Serum resistin level was similar in GDM and non-GDM patients. The serum levels of resistin in GDM and non-GDM women with GG genotype were similar to those with GC + CC genotype. Multivariate logistic regression analysis after adjusting for confounding factors showed a higher susceptibility to GDM in patients with GG genotype compared to subjects with GG + GT genotype (odds ratio = 4.59, 95% CI; 1.96-10.71, p = 0.00). Serum resistin level was correlated with serum triglyceride, total and low density lipoprotein (LDL) cholesterol (p < 0.05) in GDM patients. No significant association was found between serum resistin, insulin resistance, and SNP-420C > G.ConclusionThe SNP-420C/G of resistin gene is associated with genetic susceptibility to GDM in our population. Further studies are necessary to confirm the role of this polymorphism in pathogenesis of GDM and to explore potential mechanisms by which it modulates susceptibility to GDM.

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Maternal serum resistin concentrations in gestational diabetes mellitus and normal pregnancies

Cited by 24 publications

References 36 publications

First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

Maternal circulating adipokine profile and insulin resistance in women at high risk of developing gestational diabetes mellitus

Resistin – 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus

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