Maternal serum lipids in women with pre-eclampsia

Siddiqui, IA

doi:10.4103/2141-9248.139358

Cited by 34 publications

(24 citation statements)

References 25 publications

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“…which was sta s cally significant with p <0.001. This was 24 consistent with the studies done by A Siddiqui and Ghaffar 25 et.al. indica ng the implica on of raised serum triglyceride levels in the pathogenesis of pre-eclampsia.…”

supporting

confidence: 93%

Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

Rizal

Joshi

Dhakal

et al. 2020

Birat J. Health Sci.

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Introduction: Pre-eclampsia, one of the most common medical complication in pregnancy results in considerable maternal and fetal morbidity and mortality. Endothelial dysfunction is a central feature of pre-eclampsia. Elevated serum uric acid level may serve as a marker for early diagnosis of the disease as well as a surrogate for clinical severity of the condition. High serum values of triglycerides, total cholesterol, low- density lipoprotein and and low levels of high density lipoprotein are all significantly related to risk developing preeclampsia. Objective: To find out the association between serum uric acid levels and lipid profile in pre-eclamptic women and compare it with the normal pregnant women. Methodology: A case control study was conducted among 180 pregnant women (90 cases of pre-eclamptic women and 90 cases of age matched normal pregnant women) between 21-35 years who were admitted in the Gynaecology and Obstetrics ward of Nobel Medical College and Teaching Hospital, Biratnagar. Blood pressure was measured. Serum from all the patients were analyzed for the following biochemical parameters: serum uric acid, triglyceride, total cholesterol, LDL-C and HDL- C. The data were collected and entered in MS-Excel and analyzed using Statistical Package for Social Sciences (SPSS) ver. 16 software. Results: Mean serum uric acid of pre-eclamptic women was higher than those of normal pregnant women which was found to be statistically significant with p value <0.001. Among the lipid parameters, serum triglyceride and total cholesterol was significantly higher in pre-eclamptic women whereas high density lipoprotein was significantly lower in pre-eclamptic. Also there was a positive co-relation between triglyceride and blood pressure and a negative co-relation between HDL-C in preeclamptic women. Conclusion: Development of simple and inexpensive methods to predict and prevent pre-eclampsia in early stage is very important. Thus, our study concludes the utility of measurement of serum uric acid and lipid profile for screening patients at risk of developing pre-eclampsia.

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supporting

confidence: 93%

Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

Rizal

Joshi

Dhakal

et al. 2020

Birat J. Health Sci.

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“…Increased TG in pre-eclampsia are likely to be deposited in uterine spiral arteries and contribute to the endothelial dysfunction, both directly and indirectly through generation of small, dense LDL. 14 In present study, serum VLDL level increased significantly in PIH, and this is in accordance with the study done by Jayanta De et al The increase in the VLDL value is perhaps due to hypertriglyceridemia leading to enhanced entry of VLDL that carries endogenous triglyceride into circulation. 15 Sattar et al 16 reported no significant alteration in TC level whereas in our study statistically significant increase was seen in TC level in PIH women than in control group.…”

Section: Resultssupporting

confidence: 93%

Comparative Evaluation of Lipid Profile among Pregnant Women with and without Pregnancy Induced Hypertension Attending in Patliputra Medical College Dhanbad, Jharkhand

Kumari¹,

Kumar²,

Tiwary³

2018

IJCMR

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Introduction:The association of alteration of serum lipid profile in hypertension has been well established. In pregnancy, normally, the altered levels of serum lipid profile increase the risk of Pregnancy-induced hypertension (PIH) which is one of the major causes of maternal and fetal mortality. Therefore, the present study was designed to investigate the alteration in serum lipid profile in pregnant women and in women with PIH. Study aimed to record the levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL) and triglycerides (TG) in healthy pregnant women and women with pregnancy induced hypertension Material and Methods: 90 pregnant women were recruited for this study. An informed consent was taken from each patient. Lipid profiles were assessed using standard procedures. Data was analyzed using SPSS for Windows (version 17.0, SPSS Inc., Chicago, Illinois, USA). The data is presented descriptively and test for significance was done using the student t-test for continous data.Results: the serum lipid levels of TC, VLDL, LDL and TG in PIH women were found to be higher and were statistically significant while HDL value was not significant, as compared with the healthy controls. Conclusion:From the results of our study, it can be concluded that lipid parameters are increased in pregnancy induced hypertension which may be helpful in the prevention of complication caused by PIH.

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“…Twenty‐seven studies reported on HDL levels,32, 37, 41, 44, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 of which 24 studies could be included in a meta‐analysis 32, 37, 41, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72. HDL level was lower in pre‐eclampsia than in controls (mean difference −6.29 mmol/L; 95%CI −9.74−2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre‐eclampsia vs. controls ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-seven studies reported on HDL levels, 32,37,41,44, of which 24 studies could be included in a metaanalysis. 32,37,41,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] HDL level was lower in pre-eclampsia than in controls (mean difference À6.29 mmol/L; 95%CI À9.74À2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre-eclampsia vs. controls (Figure 4).…”

Section: High-density Lipoproteinmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Maternal serum lipids in women with pre-eclampsia

Cited by 34 publications

References 25 publications

Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

Comparative Evaluation of Lipid Profile among Pregnant Women with and without Pregnancy Induced Hypertension Attending in Patliputra Medical College Dhanbad, Jharkhand

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

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