Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

Abstract

Introduction: Pre-eclampsia, one of the most common medical complication in pregnancy results in considerable maternal and fetal morbidity and mortality. Endothelial dysfunction is a central feature of pre-eclampsia. Elevated serum uric acid level may serve as a marker for early diagnosis of the disease as well as a surrogate for clinical severity of the condition. High serum values of triglycerides, total cholesterol, low- density lipoprotein and and low levels of high density lipoprotein are all significantly related to risk developing preeclampsia. 
 Objective: To find out the association between serum uric acid levels and lipid profile in pre-eclamptic women and compare it with the normal pregnant women. 
 Methodology: A case control study was conducted among 180 pregnant women (90 cases of pre-eclamptic women and 90 cases of age matched normal pregnant women) between 21-35 years who were admitted in the Gynaecology and Obstetrics ward of Nobel Medical College and Teaching Hospital, Biratnagar.
 Blood pressure was measured. Serum from all the patients were analyzed for the following biochemical parameters: serum uric acid, triglyceride, total cholesterol, LDL-C and HDL- C. The data were collected and entered in MS-Excel and analyzed using Statistical Package for Social Sciences (SPSS) ver. 16 software.
 Results: Mean serum uric acid of pre-eclamptic women was higher than those of normal pregnant women which was found to be statistically significant with p value <0.001. Among the lipid parameters, serum triglyceride and total cholesterol was significantly higher in pre-eclamptic women whereas high density lipoprotein was significantly lower in pre-eclamptic. Also there was a positive co-relation between triglyceride and blood pressure and a negative co-relation between HDL-C in preeclamptic women.
 Conclusion: Development of simple and inexpensive methods to predict and prevent pre-eclampsia in early stage is very important. Thus, our study concludes the utility of measurement of serum uric acid and lipid profile for screening patients at risk of developing pre-eclampsia.

Evaluation of serum lipid profiles, uric acid, and high sensitivity C‐reactive protein levels between pregnancy‐induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case‐control study

“…About 88.6% of women with PIH have shown that serum TG concentration levels are above the baseline value. This result is in line with the previous study 6,35 . The elevation of serum TG may be due to a decrease in hepatic lipase activity responsible for the endogenous biosynthesis of TG and diminished lipoprotein lipase activity that keeps TG in adipocyte tissue 27 .…”

“…This result is in line with the previous study. 6,35 The elevation of serum TG may be due to a decrease in hepatic lipase activity responsible for the endogenous biosynthesis of TG and diminished lipoprotein lipase activity that keeps TG in adipocyte tissue. 27 This contributes to an endothelial pathology directly predisposed in uterine vessels or indirectly via generating small size dense LDL-C (sLDL-C) and/or it should be related to hypercoagulability.…”

Impact of serum uric acid concentration on ultrasound scanned pregnant women in Calabar, Nigeria

“…A rapid elevation of uric acid during pregnancy can occur from the 1 st trimester and such event is a precursor and predictor of the commencement of gestational hypertension and pre-eclampsia. In fact, the severity of pre-eclampsia is a direct function of the serum level of uric acid (Roberts et al, 2005;Johnson et al, 2011;Manjareeka and Nanda, 2013;Yalamati et al, 2015;Zangana and Hamadamen, 2018;Rizal et al, 2019). Reverting serum uric acid to normal levels lowers elevated blood pressure to a normal state (Park et al, 2009) but a similar study bizarrely proposed that increasing salt intake reduces serum uric acid concentration (Wang et al, 2018).…”